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Liquiritigenin (LTG) and its bioprecursor isoliquiritigenin(ISL), the main bioactives from roots of Glycyrrhiza genus are progressively documented as a potential pharmacological agent for the management of chronic diseases. The aim of this study was to evaluate the pharmacological potential of liquiritigenin, isoliquiritigenin rich extract of Glycyrrhiza glabra roots (IVT-21) against the production of pro-inflammatory cytokines from activated macrophages as well as further validated the efficacy in collagen-induced arthritis model in rats. We also performed the safety profile of IVT-21 using standard in-vitro and in-vivo assays. Results of this study revealed that the treatment of IVT-21 and its major bioactives (LTG, ISL) was able to reduce the production of pro-inflammatory cytokines (TNF-α, IL-6) in LPS-activated primary peritoneal macrophages in a dose-dependent manner compared with vehicle-alone treated cells without any cytotoxic effect on macrophages. In-vivo efficacy profile against collagen-induced arthritis in Rats revealed that oral administration of IVT-21 significantly reduced the arthritis index, arthritis score, inflammatory mediators level in serum. IVT-21 oral treatment is also able to reduce the NFкB-p65 expression as evidence of immunohistochemistry in knee joint tissue and mRNA level of pro-inflammatory cytokines in paw tissue in a dose-dependent manner when compared with vehicle treated rats. Acute oral toxicity profile of IVT-21 demonstrated that it is safe up to 2000 mg/kg body weight in experimental mice. This result suggests the suitability of IVT-21 for further study in the management of arthritis and related complications.

Titel:	Liquiritigenin, isoliquiritigenin rich extract of glycyrrhiza glabra roots attenuates inflammation in macrophages and collagen-induced arthritis in rats.
Autor/in / Beteiligte Person:	Babu, V ; Kapkoti, DS ; Binwal, M ; Bhakuni, RS ; Shanker, K ; Singh, M ; Tandon, S ; Mugale, MN ; Kumar, N ; Bawankule, DU
Link:	Full Text Finder (Volltext)
Zeitschrift:	Inflammopharmacology, Jg. 31 (2023-04-01), Heft 2, S. 983-996
Veröffentlichung:	Basel ; Boston : Birkhäuser ; <i>Original Publication</i>: Dordrecht, The Netherlands ; Norwell, MA, USA : Kluwer Academic Publishers, c1991-, 2023
Medientyp:	academicJournal
ISSN:	1568-5608 (electronic)
DOI:	10.1007/s10787-023-01152-w
Schlagwort:	Rats Mice Animals Inflammation drug therapy Inflammation metabolism Plant Extracts therapeutic use Cytokines metabolism Macrophages Arthritis, Experimental drug therapy Arthritis, Experimental metabolism Glycyrrhiza metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Inflammopharmacology] 2023 Apr; Vol. 31 (2), pp. 983-996. <i>Date of Electronic Publication: </i>2023 Mar 22. MeSH Terms: Arthritis, Experimental* / drug therapy ; Arthritis, Experimental* / metabolism ; Glycyrrhiza* / metabolism ; Rats ; Mice ; Animals ; Inflammation / drug therapy ; Inflammation / metabolism ; Plant Extracts / therapeutic use ; Cytokines / metabolism ; Macrophages References: Alam J, Jantan I, Bukhari SNA (2017) Rheumatoid arthritis: recent advances on its etiology, role of cytokines and pharmacotherapy. Biomed Pharmacother 92:615–633. (PMID: 2858275810.1016/j.biopha.2017.05.055) ; Anil K, Jyotsna D (2012) Review on Glycyrrhiza glabra (Liquorice). J Pharm Sci Innovation 1(2):1–4. ; Arseculeratne SN, Gunatilaka AAL, Panabokke RG (1985) Studies on medicinal plants of Sri Lanka. Part 14: toxicity of some traditional medicinal herbs. J Ethnopharmacol 13:323–335. 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(PMID: 3456053510.1016/j.biopha.2021.112167) Grant Information: HCP-010 csir-cimap; CSIR- Emeritus Scientist project 21(1050)/18 EMR-II csir-cimap Contributed Indexing: Keywords: Anti-inflammatory arthritis; Glycyrrhiza glabra; Isoliquiritigenin; Liquiritigenin; Root Substance Nomenclature: B9CTI9GB8F (isoliquiritigenin) ; T194LKP9W6 (liquiritigenin) ; 0 (Plant Extracts) ; 0 (Cytokines) Entry Date(s): Date Created: 20230322 Date Completed: 20230501 Latest Revision: 20230501 Update Code: 20231215

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Liquiritigenin, isoliquiritigenin rich extract of glycyrrhiza glabra roots attenuates inflammation in macrophages and collagen-induced arthritis in rats.