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There is growing concern that Coronavirus Disease 2019 (COVID-19) vaccine fatigue will be a major obstacle in maintaining immunity in the general population. In this study, we assessed vaccine acceptance in future scenarios in two conjoint experiments, investigating determinants such as new vaccines, communication, costs/incentives and legal rules. The experiments were embedded in an online survey (n = 6,357 participants) conducted in two European countries (Austria and Italy). Our results suggest that vaccination campaigns should be tailored to subgroups based on their vaccination status. Among the unvaccinated, campaign messages conveying community spirit had a positive effect (0.343, confidence interval (CI) 0.019-0.666), whereas offering positive incentives, such as a cash reward (0.722, CI 0.429-1.014) or voucher (0.670, CI 0.373-0.967), was pivotal to the decision-making of those vaccinated once or twice. Among the triple vaccinated, vaccination readiness increased when adapted vaccines were offered (0.279, CI 0.182-0.377), but costs (-0.795, CI -0.935 to -0.654) and medical dissensus (-0.161, CI -0.293 to -0.030) reduced their likelihood to get vaccinated. We conclude that failing to mobilize the triple vaccinated is likely to result in booster vaccination rates falling short of expectations. For long-term success, measures fostering institutional trust should be considered. These results provide guidance to those responsible for future COVID-19 vaccination campaigns.

Titel:	Determinants of COVID-19 vaccine fatigue.
Autor/in / Beteiligte Person:	Stamm, TA ; Partheymüller, J ; Mosor, E ; Ritschl, V ; Kritzinger, S ; Alunno, A ; Eberl, JM
Zeitschrift:	Nature medicine, Jg. 29 (2023-05-01), Heft 5, S. 1164-1171
Veröffentlichung:	New York Ny : Nature Publishing Company ; <i>Original Publication</i>: New York, NY : Nature Pub. Co., [1995-, 2023
Medientyp:	academicJournal
ISSN:	1546-170X (electronic)
DOI:	10.1038/s41591-023-02282-y
Schlagwort:	Humans Communication Europe epidemiology Fatigue Vaccination COVID-19 Vaccines therapeutic use COVID-19 epidemiology COVID-19 prevention & control
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Nat Med] 2023 May; Vol. 29 (5), pp. 1164-1171. <i>Date of Electronic Publication: </i>2023 Mar 27. MeSH Terms: COVID-19 Vaccines* / therapeutic use ; COVID-19* / epidemiology ; COVID-19* / prevention & control ; Humans ; Communication ; Europe / epidemiology ; Fatigue ; Vaccination References: Lazarus, J. V. et al. A multinational Delphi consensus to end the COVID-19 public health threat. Nature 611, 332–345 (2022). (PMID: 363292729646517) ; Duong, D. & Vogel, L. Booster uptake stalling as experts debate fourth COVID shots. CMAJ 194, E532–E533 (2022). (PMID: 354108659001004) ; Quartz. The USʼs estimate for uptake of the new covid booster was off by more than 90%. https://qz.com/the-uss-estimate-for-uptake-of-the-new-covid-booster-wa-1849639093 (2022). ; Larson, H. J., Gakidou, E. & Murray, C. J. The vaccine-hesitant moment. N. Engl. J. 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Determinants of COVID-19 vaccine fatigue.