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Background: MicroRNAs (miRs) are small (19-25 nucleotides), non-protein coding RNAs that regulate gene expression, and thus play essential roles in cell cycle progression. The evidence has demonstrated that the expression of several miRs is dysregulated in human cancer.

Methods: The study includes 179 female patients and 58 healthy women Patients were identified as luminal A, B, Her-2/neu, and basal-like, as well as classified into I, II, and III stages. Analysis of the expression fold change of miR-21 and miR-34a with molecular markers, including the oncogene Bcl-2 (B-cell lymphoma 2) and the tumor suppressor genes BRCA1 (breast cancer susceptibility gene 1), BRCA2 (breast cancer susceptibility gene 2), and the tumor suppressor protein p53, was carried out for all patients, pre- and post-chemotherapy, and for all healthy women.

Results: At diagnosis (pre-chemotherapy), miR-21 was up-regulated ( p < 0.001), while miR-34a was down-regulated ( p < 0.001). Post-chemotherapy, the expression of miR-21 decreased significantly ( p < 0.001), while the expression of miR-34a increased significantly ( p < 0.001).

Conclusion: miR-21 and miR-34a may be helpful to non-invasive biomarkers to evaluate the response of breast cancer to chemotherapy.

Competing Interests: All patients’ written consent was obtained for the publication of any associated data.

Titel:	The Implication of microRNAs as non-invasive biomarkers in 179 Egyptian breast cancer female patients.
Autor/in / Beteiligte Person:	Shaaban, NZ ; Ibrahim, NK ; Saada, HN ; El-Rashidy, FH ; Shaaban, HM ; Elbakary, NM ; Kodous, AS
Link:	Full Text Finder (Volltext)
Zeitschrift:	Oncology research, Jg. 30 (2023-02-09), Heft 6, S. 269-276
Veröffentlichung:	2021- : Henderson, NV : Tech Science Press ; <i>Original Publication</i>: New York : Pergamon Press, c1992-, 2023
Medientyp:	academicJournal
ISSN:	1555-3906 (electronic)
DOI:	10.32604/or.2022.027277
Schlagwort:	Humans Female Egypt Oncogenes Biomarkers MicroRNAs genetics Breast Neoplasms genetics
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Oncol Res] 2023 Feb 09; Vol. 30 (6), pp. 269-276. <i>Date of Electronic Publication: </i>2023 Feb 09 (<i>Print Publication: </i>2022). MeSH Terms: MicroRNAs* / genetics ; Breast Neoplasms* / genetics ; Humans ; Female ; Egypt ; Oncogenes ; Biomarkers References: Cancer Res. 2005 Aug 15;65(16):7065-70. (PMID: 16103053) ; Ann Surg. 2010 Mar;251(3):499-505. (PMID: 20134314) ; Mol Ther. 2012 Dec;20(12):2326-34. (PMID: 23032974) ; Mol Cell. 2007 Jun 8;26(5):745-52. (PMID: 17540599) ; Cancer Metastasis Rev. 2009 Dec;28(3-4):369-78. (PMID: 20012925) ; Int J Mol Sci. 2012 Oct 18;13(10):13414-37. (PMID: 23202960) ; Ann Oncol. 2017 Feb 1;28(2):208-217. (PMID: 27831505) ; Int J Mol Sci. 2017 Jun 02;18(6):. (PMID: 28574440) ; BMC Biotechnol. 2007 Jun 29;7:36. (PMID: 17603869) ; J Pediatr. 2010 Feb;156(2 Suppl):S36-40. (PMID: 20105664) ; Methods. 2001 Dec;25(4):402-8. (PMID: 11846609) ; Oncotarget. 2017 Apr 4;8(14):23177-23187. (PMID: 28423566) ; J Mol Cell Biol. 2014 Jun;6(3):214-30. (PMID: 24815299) ; J Dent Res. 2011 Aug;90(8):995-1000. (PMID: 21622902) ; Breast Cancer Res. 2010;12(2):201. (PMID: 20346098) ; PLoS One. 2012;7(6):e39520. (PMID: 22761812) ; RNA. 2008 Nov;14(11):2348-60. (PMID: 18812439) ; Oncotarget. 2016 Jun 7;7(23):34498-506. (PMID: 27153564) ; Crit Rev Oncol Hematol. 1999 Aug;31(3):209-23. (PMID: 10532196) ; Am J Med Sci. 2016 Aug;352(2):191-9. (PMID: 27524218) ; Nucleic Acids Res. 2005 Nov 27;33(20):e179. (PMID: 16314309) ; Methods Enzymol. 2007;427:107-22. (PMID: 17720481) ; Nature. 2005 Jun 9;435(7043):834-8. (PMID: 15944708) ; Pathol Res Pract. 2010 Aug 15;206(8):578-84. (PMID: 20418022) ; JAMA. 2019 Jan 22;321(3):288-300. (PMID: 30667505) ; Cancer Treat Rev. 2010 May;36(3):206-15. (PMID: 20060649) ; CA Cancer J Clin. 2018 Nov;68(6):394-424. (PMID: 30207593) ; Mol Cell Biochem. 2012 Apr;363(1-2):427-36. (PMID: 22187223) ; J Clin Endocrinol Metab. 2002 Mar;87(3):1223-32. (PMID: 11889192) ; Curr Treat Options Oncol. 2012 Jun;13(2):263-75. (PMID: 22528367) ; J Clin Oncol. 2005 May 1;23(13):2903-10. (PMID: 15753461) ; Nucleic Acids Res. 2005 Sep 28;33(17):5394-403. (PMID: 16192569) Contributed Indexing: Keywords: BRCA1 and BRCA2; Bcl-2; Breast-cancer; miR-21 and miR-34a; p53 Substance Nomenclature: 0 (MicroRNAs) ; 0 (Biomarkers) Entry Date(s): Date Created: 20230612 Date Completed: 20230613 Latest Revision: 20230613 Update Code: 20231215 PubMed Central ID: PMC10208075

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The Implication of microRNAs as non-invasive biomarkers in 179 Egyptian breast cancer female patients.