Einzeltreffer — DigiBib

Background: Recently, the hallmarks of aging were updated to include dysbiosis, disabled macroautophagy, and chronic inflammation. In particular, the low-grade chronic inflammation during aging, without overt infection, is defined as "inflammaging," which is associated with increased morbidity and mortality in the aging population. Emerging evidence suggests a bidirectional and cyclical relationship between chronic inflammation and the development of age-related conditions, such as cardiovascular diseases, neurodegeneration, cancer, and frailty. How the crosstalk between chronic inflammation and other hallmarks of aging underlies biological mechanisms of aging and age-related disease is thus of particular interest to the current geroscience research.

Scope of Review: This review integrates the cellular and molecular mechanisms of age-associated chronic inflammation with the other eleven hallmarks of aging. Extra discussion is dedicated to the hallmark of "altered nutrient sensing," given the scope of Molecular Metabolism. The deregulation of hallmark processes during aging disrupts the delicate balance between pro-inflammatory and anti-inflammatory signaling, leading to a persistent inflammatory state. The resultant chronic inflammation, in turn, further aggravates the dysfunction of each hallmark, thereby driving the progression of aging and age-related diseases.

Main Conclusions: The crosstalk between chronic inflammation and other hallmarks of aging results in a vicious cycle that exacerbates the decline in cellular functions and promotes aging. Understanding this complex interplay will provide new insights into the mechanisms of aging and the development of potential anti-aging interventions. Given their interconnectedness and ability to accentuate the primary elements of aging, drivers of chronic inflammation may be an ideal target with high translational potential to address the pathological conditions associated with aging.

Competing Interests: Declaration of competing interest DF is co-founder and & Chairman of the Scientific Advisory Board of Edifice Health, a company that utilizes Inflammatory Age (iAge) to quantify chronic inflammation and immune health. The remaining authors declare no competing interests.

Titel:	Chronic inflammation and the hallmarks of aging.
Autor/in / Beteiligte Person:	Baechle, JJ ; Chen, N ; Makhijani, P ; Winer, S ; Furman, D ; Winer, DA
Link:	Full Text Finder (Volltext)
Zeitschrift:	Molecular metabolism, Jg. 74 (2023-08-01), S. 101755
Veröffentlichung:	[München] : Elsevier GmbH, 2012-, 2023
Medientyp:	academicJournal
ISSN:	2212-8778 (electronic)
DOI:	10.1016/j.molmet.2023.101755
Schlagwort:	Humans Aged Anti-Inflammatory Agents Inflammation Cardiovascular Diseases
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Review; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural Language: English [Mol Metab] 2023 Aug; Vol. 74, pp. 101755. <i>Date of Electronic Publication: </i>2023 Jun 15. MeSH Terms: Inflammation* ; Cardiovascular Diseases* ; Humans ; Aged ; Anti-Inflammatory Agents References: Subcell Biochem. 2023;102:139-173. (PMID: 36600133) ; Cell. 2019 Apr 18;177(3):722-736.e22. (PMID: 30955890) ; Redox Biol. 2023 Feb;59:102561. (PMID: 36512915) ; Cell Mol Immunol. 2021 Dec;18(12):2609-2617. (PMID: 34728795) ; Int J Cancer. 2012 Apr 15;130(8):1715-25. (PMID: 22025288) ; Biomed Pharmacother. 2023 Jan;157:114036. (PMID: 36436493) ; J Clin Med. 2021 Apr 20;10(8):. (PMID: 33923887) ; Cancer Res. 2001 May 1;61(9):3573-7. (PMID: 11325821) ; Stem Cell Res Ther. 2022 Jan 31;13(1):44. (PMID: 35101092) ; Cell Stem Cell. 2022 Aug 4;29(8):1273-1284.e8. 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Chronic inflammation and the hallmarks of aging.