The effect of 17beta-estradiol plus norethisterone acetate on anthropometric indices: A systematic review and meta-analysis of randomized controlled trials.

Li, Y ; Chen, X ; et al.

In: European journal of obstetrics, gynecology, and reproductive biology, Jg. 287 (2023-08-01), S. 176-185

academicJournal

Objective: Little evidence exists on the effect of 17beta-estradiol plus norethisterone acetate on all the anthropometric indices. Hence, this systematic review and meta-analysis of Randomized Controlled Trials was conducted to give an evidence-based report on the effect of 17beta-estradiol plus norethisterone acetate on anthropometric indices.

Methods: The literature search was executed in databases including PubMed/Medline, Web of Science, Scopus, Embase, and Google Scholar to recognize clinical trials that examined the influence of 17beta-estradiol plus norethisterone acetate on obesity indices from database inception to Jan 2023.

Results: Combined findings were generated from 20 eligible articles. The meta-analysis showed that body weight (Weighted Mean Difference (WMD): -0.47 kg, 95% CI: -1.32, 0.37, p = 0.274), body fat (WMD: 0.16 kg, 95% CI: -1.26, 1.59, p = 0.821), WHR (WMD: 0.001 kg, 95% CI: -0.006, 1.15, p = 0.872), and LBM (WMD: -0.02 kg, 95% CI: -1.19, 1.15, p = 0.970) were not modified in DHEA group compared to the control, but BMI levels were significantly reduced in 17beta-estradiol plus norethisterone acetate group (WMD: -0.15 kg/m2, 95% CI: -0.30, -0.008, p = 0.039). Moreover, based on intervention duration (months), a more significant reduction in BMI was found in trials that were performed on studies with ˃3 months duration (WMD: -0.176 kg/m2) than studies with ≤ 3 months (WMD: 0.05 kg/m2).

Conclusion: Administration of 17beta-estradiol plus norethisterone acetate for more than 3 months results in a decrease in BMI, which helps to reduce cardiovascular disease risk.

Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Titel:	The effect of 17beta-estradiol plus norethisterone acetate on anthropometric indices: A systematic review and meta-analysis of randomized controlled trials.
Autor/in / Beteiligte Person:	Li, Y ; Chen, X ; Gong, X ; He, D ; Cheng, X ; Prabahar, K ; Hernández-Wolters, B ; Velu, P ; Du, W
Zeitschrift:	European journal of obstetrics, gynecology, and reproductive biology, Jg. 287 (2023-08-01), S. 176-185
Veröffentlichung:	Limerick : Elsevier Scientific Publishers ; <i>Original Publication</i>: Amsterdam, Excerpta Medica., 2023
Medientyp:	academicJournal
ISSN:	1872-7654 (electronic)
DOI:	10.1016/j.ejogrb.2023.06.019
Schlagwort:	Humans Norethindrone Acetate Randomized Controlled Trials as Topic Body Weight Dietary Supplements analysis Obesity Estradiol
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Meta-Analysis; Systematic Review; Journal Article; Review Language: English [Eur J Obstet Gynecol Reprod Biol] 2023 Aug; Vol. 287, pp. 176-185. <i>Date of Electronic Publication: </i>2023 Jun 22. MeSH Terms: Obesity* ; Estradiol* ; Humans ; Norethindrone Acetate ; Randomized Controlled Trials as Topic ; Body Weight ; Dietary Supplements / analysis Contributed Indexing: Keywords: 17beta-estradiol plus norethisterone acetate; BMI; Meta-analysis; Obesity; Weight Substance Nomenclature: 9S44LIC7OJ (Norethindrone Acetate) ; 4TI98Z838E (Estradiol) Entry Date(s): Date Created: 20230626 Date Completed: 20230717 Latest Revision: 20230718 Update Code: 20240513

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