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The additional therapeutic effects of regular exercise during a dietary weight loss program in people with obesity and prediabetes are unclear. Here, we show that whole-body (primarily muscle) insulin sensitivity (primary outcome) was 2-fold greater (P = 0.006) after 10% weight loss induced by calorie restriction plus exercise training (Diet+EX; n = 8, 6 women) than 10% weight loss induced by calorie restriction alone (Diet-ONLY; n = 8, 4 women) in participants in two concurrent studies. The greater improvement in insulin sensitivity was accompanied by increased muscle expression of genes involved in mitochondrial biogenesis, energy metabolism and angiogenesis (secondary outcomes) in the Diet+EX group. There were no differences between groups in plasma branched-chain amino acids or markers of inflammation, and both interventions caused similar changes in the gut microbiome. Few adverse events were reported. These results demonstrate that regular exercise during a diet-induced weight loss program has profound additional metabolic benefits in people with obesity and prediabetes.Trial Registration: ClinicalTrials.gov (NCT02706262 and NCT02706288).

Titel:	Dietary weight loss-induced improvements in metabolic function are enhanced by exercise in people with obesity and prediabetes.
Autor/in / Beteiligte Person:	Beals, JW ; Kayser, BD ; Smith, GI ; Schweitzer, GG ; Kirbach, K ; Kearney, ML ; Yoshino, J ; Rahman, G ; Knight, R ; Patterson, BW ; Klein, S
Zeitschrift:	Nature metabolism, Jg. 5 (2023-07-01), Heft 7, S. 1221-1235
Veröffentlichung:	Berlin : Springer Nature, [2019]-, 2023
Medientyp:	academicJournal
ISSN:	2522-5812 (electronic)
DOI:	10.1038/s42255-023-00829-4
Schlagwort:	Humans Insulin Resistance Caloric Restriction Organelle Biogenesis Energy Metabolism Gastrointestinal Microbiome Male Female Cardiorespiratory Fitness Muscle, Skeletal Blood Glucose Transcriptome Proteome Adult Prediabetic State diet therapy Exercise Obesity diet therapy Weight Loss
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Language: English [Nat Metab] 2023 Jul; Vol. 5 (7), pp. 1221-1235. <i>Date of Electronic Publication: </i>2023 Jun 26. MeSH Terms: Prediabetic State* / diet therapy ; Exercise* ; Obesity* / diet therapy ; Weight Loss* ; Humans ; Insulin Resistance ; Caloric Restriction ; Organelle Biogenesis ; Energy Metabolism ; Gastrointestinal Microbiome ; Male ; Female ; Cardiorespiratory Fitness ; Muscle, Skeletal ; Blood Glucose ; Transcriptome ; Proteome ; Adult References: Med Sci Sports Exerc. 2009 Feb;41(2):459-71. (PMID: 19127177) ; Med Sci Sports Exerc. 2002 Sep;34(9):1505-8. (PMID: 12218746) ; Am J Physiol Endocrinol Metab. 2000 Aug;279(2):E348-55. (PMID: 10913035) ; J Clin Invest. 2020 Jun 1;130(6):3305-3314. (PMID: 32191646) ; PLoS One. 2010 Dec 07;5(12):e15004. (PMID: 21165148) ; Diabetes Care. 1983 May-Jun;6(3):268-73. (PMID: 6307614) ; J Appl Physiol (1985). 1996 Jul;81(1):318-25. (PMID: 8828680) ; Diabetes Care. 1995 Feb;18(2):245-50. (PMID: 7729306) ; J Clin Invest. 2022 Feb 1;132(3):. (PMID: 34905513) ; J Clin Endocrinol Metab. 2011 Apr;96(4):1085-92. (PMID: 21252241) ; Diabetes Care. 2006 Jun;29(6):1337-44. (PMID: 16732018) ; Physiol Rev. 2018 Oct 1;98(4):2133-2223. (PMID: 30067154) ; Am J Health Behav. 2019 Nov 1;43(6):1136-1147. (PMID: 31662172) ; Cardiovasc Endocrinol Metab. 2020 Nov 19;10(3):149-161. (PMID: 34386716) ; Gastroenterology. 2012 Oct;143(4):913-6.e7. (PMID: 22728514) ; Gastroenterology. 2002 Sep;123(3):882-932. (PMID: 12198715) ; J Clin Endocrinol Metab. 2020 Aug 1;105(8):. (PMID: 32492705) ; Nat Commun. 2019 Jun 20;10(1):2719. (PMID: 31222023) ; Med Sci Sports Exerc. 2022 Oct 1;54(10):1714-1728. (PMID: 35522254) ; mSystems. 2018 Apr 17;3(3):. (PMID: 29719869) ; Am J Clin Nutr. 1990 Feb;51(2):241-7. (PMID: 2305711) ; Diabetologia. 2021 May;64(5):1158-1168. (PMID: 33511440) ; Cell Metab. 2016 Apr 12;23(4):591-601. (PMID: 26916363) ; Cell Metab. 2017 Oct 3;26(4):611-619.e6. (PMID: 28978426) ; mSystems. 2018 May 15;3(3):. (PMID: 29795809) ; Nucleic Acids Res. 2015 Apr 20;43(7):e47. (PMID: 25605792) ; Annu Rev Nutr. 2016 Jul 17;36:337-67. (PMID: 27146012) ; J Cardiometab Syndr. 2006 Fall;1(5):308-12. (PMID: 17679787) ; Endocr Pract. 2016 Jul;22 Suppl 3:1-203. (PMID: 27219496) ; J Clin Invest. 2019 Oct 1;129(10):4050-4057. (PMID: 31573550) ; Prog Cardiovasc Dis. 1976 May-Jun;18(6):445-58. (PMID: 180563) ; JAMA. 2018 Sep 18;320(11):1163-1171. (PMID: 30326502) ; J Appl Physiol (1985). 2000 Dec;89(6):2276-82. (PMID: 11090579) ; J Am Coll Cardiol. 2014 Jul 1;63(25 Pt B):2985-3023. (PMID: 24239920) ; Med Sci Sports Exerc. 2020 Jul;52(7):1449-1455. (PMID: 32028458) ; Diabetes Care. 1999 Sep;22(9):1462-70. (PMID: 10480510) ; Diabetes. 2010 Aug;59(8):1899-905. (PMID: 20522594) ; Gastroenterology. 2021 Sep;161(3):968-981.e12. (PMID: 34004161) ; N Engl J Med. 1996 Oct 31;335(18):1357-62. (PMID: 8857019) ; Diabetes. 2008 Apr;57(4):987-94. (PMID: 18252894) ; Metabolism. 1982 May;31(5):457-62. (PMID: 7043178) ; Diabetes. 1985 Oct;34(10):973-9. (PMID: 3930321) ; JAMA. 2007 Mar 7;297(9):969-77. (PMID: 17341711) ; Diabetes. 1984 Apr;33(4):311-8. (PMID: 6368289) ; J Clin Endocrinol Metab. 2006 Aug;91(8):3224-7. (PMID: 16684829) ; Diabetes Care. 2015 Jul;38(7):1253-62. (PMID: 25877812) ; Int J Obes (Lond). 2014 Mar;38(3):423-31. (PMID: 23823329) ; J Clin Endocrinol Metab. 2005 Jun;90(6):3191-6. (PMID: 15769987) ; J Clin Endocrinol Metab. 2012 Jul;97(7):2512-20. (PMID: 22569236) ; Hepatology. 2012 Sep;56(3):922-32. (PMID: 22431131) ; Diabetes Metab J. 2016 Aug;40(4):253-71. (PMID: 27535644) ; Diabetes. 2006 Dec;55 Suppl 2:S9-S15. (PMID: 17130651) ; Med Sci Sports Exerc. 2019 Oct;51(10):2109-2116. (PMID: 31033904) ; Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23822-23828. (PMID: 31694884) ; J Clin Endocrinol Metab. 2009 Nov;94(11):4258-66. (PMID: 19808853) ; Diabetologia. 1985 Jul;28(7):412-9. (PMID: 3899825) ; Am J Physiol Endocrinol Metab. 2001 Dec;281(6):E1333-9. (PMID: 11701450) ; J Clin Invest. 2019 Oct 1;129(10):3978-3989. (PMID: 31524630) ; Diabetes. 1992 Sep;41(9):1091-9. (PMID: 1323491) ; Nat Biotechnol. 2019 Aug;37(8):852-857. (PMID: 31341288) ; Diabetes. 2007 Aug;56(8):2093-102. (PMID: 17513702) ; Diabetes. 1992 Mar;41(3):368-77. (PMID: 1551497) ; Gastroenterology. 2008 May;134(5):1369-75. (PMID: 18355813) ; Obesity (Silver Spring). 2018 May;26(5):854-861. (PMID: 29687650) Grant Information: T32 HL130357 United States HL NHLBI NIH HHS; P30 DK056341 United States DK NIDDK NIH HHS; R01 DK104995 United States DK NIDDK NIH HHS; P30 DK020579 United States DK NIDDK NIH HHS; UL1 TR002345 United States TR NCATS NIH HHS; UL1 TR000448 United States TR NCATS NIH HHS; T32 DK007120 United States DK NIDDK NIH HHS Molecular Sequence: ClinicalTrials.gov NCT02706262; NCT02706288 Substance Nomenclature: 0 (Blood Glucose) ; 0 (Proteome) Entry Date(s): Date Created: 20230626 Date Completed: 20230808 Latest Revision: 20230923 Update Code: 20240513 PubMed Central ID: PMC10515726

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Dietary weight loss-induced improvements in metabolic function are enhanced by exercise in people with obesity and prediabetes.