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Lung injury is one of the common extra‑articular lesions in rheumatoid arthritis (RA). Due to its insidious onset and no obvious clinical symptoms, it can be easily dismissed in the early stage of diagnosis, which is one of the reasons that leads to a decline of the quality of life and subsequent death of patients with RA. However, its pathogenesis is still unclear and there is a lack of effective therapeutic targets. In the present study, tandem mass tag‑labeled proteomics was used to research the lung tissue proteins in RA model (adjuvant arthritis, AA) rats that had secondary lung injury. The aim of the present study was to identify the differentially expressed proteins related to RA‑lung injury, determine their potential role in the pathogenesis of RA‑lung injury and provide potential targets for clinical treatment. Lung tissue samples were collected from AA‑lung injury and normal rats. The differentially expressed proteins (DEPs) were identified by tandem mass spectrometry. Bioinformatic analysis was used to assess the biological processes and signaling pathways associated with these DEPs. A total of 310 DEPs were found, of which 244 were upregulated and 66 were downregulated. KEGG anlysis showed that 'fatty acid degradation', 'fatty acid metabolism', 'fatty acid elongation', 'complement and coagulation cascades', 'peroxisome proliferator‑activated receptor signaling pathway' and 'hypoxia‑inducible factor signaling pathway' were significantly upregulated in the lung tissues of AA‑lung injury. Immunofluorescence staining confirmed the increased expression of clusterin, serine protease inhibitors and complement 1qc in lung tissue of rats with AA lung injury. In the present study, the results revealed the significance of certain DEPs (for example, C9, C1qc and Clu) in the occurrence and development of RA‑lung injury and provided support through experiments to identify potential biomarkers for the early diagnosis and prevention of RA‑lung injury.

Titel:	Proteomics analysis of lung tissue reveals protein makers for the lung injury of adjuvant arthritis rats.
Autor/in / Beteiligte Person:	Zhang, PH ; Wu, DB ; Liu, J ; Wen, JT ; Chen, ES ; Xiao, CH
Zeitschrift:	Molecular medicine reports, Jg. 28 (2023-09-01), Heft 3
Veröffentlichung:	Athens, Greece : D. A. Spandidos, 2023
Medientyp:	academicJournal
ISSN:	1791-3004 (electronic)
DOI:	10.3892/mmr.2023.13051
Schlagwort:	Rats Animals Proteomics methods Quality of Life Lung pathology Fatty Acids Lung Injury etiology Arthritis, Experimental Arthritis, Rheumatoid pathology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Mol Med Rep] 2023 Sep; Vol. 28 (3). <i>Date of Electronic Publication: </i>2023 Jul 14. MeSH Terms: Lung Injury* / etiology ; Arthritis, Experimental* ; Arthritis, Rheumatoid* / pathology ; Rats ; Animals ; Proteomics / methods ; Quality of Life ; Lung / pathology ; Fatty Acids References: Front Immunol. 2023 Mar 17;14:1100461. (PMID: 37006238) ; Mol Plant. 2020 Aug 3;13(8):1194-1202. (PMID: 32585190) ; Am J Respir Crit Care Med. 2007 Dec 1;176(11):1108-19. (PMID: 17761615) ; Hum Mol Genet. 2020 Nov 4;29(18):3003-3013. (PMID: 32821949) ; Bioorg Chem. 2022 Feb;119:105519. (PMID: 34864624) ; Cartilage. 2021 Dec;13(2_suppl):1102S-1121S. (PMID: 34894777) ; Mucosal Immunol. 2022 May;15(5):927-939. (PMID: 35672453) ; Mol Cell. 2012 Dec 14;48(5):681-91. (PMID: 23103253) ; J Pers Med. 2022 Feb 15;12(2):. (PMID: 35207772) ; Cancers (Basel). 2023 May 30;15(11):. 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Proteomics analysis of lung tissue reveals protein makers for the lung injury of adjuvant arthritis rats.