Impact of symptomatic menopausal transition on the occurrence of depression, anxiety, and sleep disorders: A real-world multi-site study.
In: European psychiatry : the journal of the Association of European Psychiatrists, Jg. 66 (2023-09-12), Heft 1, S. e80
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Zugriff:
Background: The menopause transition is a vulnerable period that can be associated with changes in mood and cognition. The present study aimed to investigate whether a symptomatic menopausal transition increases the risks of depression, anxiety, and sleep disorders.
Methods: This population-based, retrospective cohort study analysed data from five electronic health record databases in South Korea. Women aged 45-64 years with and without symptomatic menopausal transition were matched 1:1 using propensity-score matching. Subgroup analyses were conducted according to age and use of hormone replacement therapy (HRT). A primary analysis of 5-year follow-up data was conducted, and an intention-to-treat analysis was performed to identify different risk windows over 5 or 10 years. The primary outcome was first-time diagnosis of depression, anxiety, and sleep disorder. We used Cox proportional hazard models and a meta-analysis to calculate the summary hazard ratio (HR) estimates across the databases.
Results: Propensity-score matching resulted in a sample of 17,098 women. Summary HRs for depression (2.10; 95% confidence interval [CI] 1.63-2.71), anxiety (1.64; 95% CI 1.01-2.66), and sleep disorders (1.47; 95% CI 1.16-1.88) were higher in the symptomatic menopausal transition group. In the subgroup analysis, the use of HRT was associated with an increased risk of depression (2.21; 95% CI 1.07-4.55) and sleep disorders (2.51; 95% CI 1.25-5.04) when compared with non-use of HRT.
Conclusions: Our findings suggest that women with symptomatic menopausal transition exhibit an increased risk of developing depression, anxiety, and sleep disorders. Therefore, women experiencing a symptomatic menopausal transition should be monitored closely so that interventions can be applied early.
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Impact of symptomatic menopausal transition on the occurrence of depression, anxiety, and sleep disorders: A real-world multi-site study.
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Autor/in / Beteiligte Person: | Lee, DY ; Andreescu, C ; Aizenstein, H ; Karim, H ; Mizuno, A ; Kolobaric, A ; Yoon, S ; Kim, Y ; Lim, J ; Hwang, EJ ; Ouh, YT ; Kim, HH ; Son, SJ ; Park, RW |
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Zeitschrift: | European psychiatry : the journal of the Association of European Psychiatrists, Jg. 66 (2023-09-12), Heft 1, S. e80 |
Veröffentlichung: | 2020- : Cambridge : Cambridge University Press ; <i>Original Publication</i>: Paris : Editions scientifiques Elsevier, c1991-, 2023 |
Medientyp: | academicJournal |
ISSN: | 1778-3585 (electronic) |
DOI: | 10.1192/j.eurpsy.2023.2439 |
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