First implementation of dynamic oxygen-17 ( <superscript>17</superscript> O) magnetic resonance imaging at 7 Tesla during neuronal stimulation in the human brain.
In: Magma (New York, N.Y.), Jg. 37 (2024-02-01), Heft 1, S. 27-38
Online
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Zugriff:
Objective: First implementation of dynamic oxygen-17 ( 17 O) MRI at 7 Tesla (T) during neuronal stimulation in the human brain.
Methods: Five healthy volunteers underwent a three-phase 17 O gas ( 17 O 2 ) inhalation experiment. Combined right-side visual stimulus and right-hand finger tapping were used to achieve neuronal stimulation in the left cerebral hemisphere. Data analysis included the evaluation of the relative partial volume (PV)-corrected time evolution of absolute 17 O water (H 2 17 O) concentration and of the relative signal evolution without PV correction. Statistical analysis was performed using a one-tailed paired t test. Blood oxygen level-dependent (BOLD) experiments were performed to validate the stimulation paradigm.
Results: The BOLD maps showed significant activity in the stimulated left visual and sensorimotor cortex compared to the non-stimulated right side. PV correction of 17 O MR data resulted in high signal fluctuations with a noise level of 10% due to small regions of interest (ROI), impeding further quantitative analysis. Statistical evaluation of the relative H 2 17 O signal with PV correction (p = 0.168) and without (p = 0.382) did not show significant difference between the stimulated left and non-stimulated right sensorimotor ROI.
Discussion: The change of cerebral oxygen metabolism induced by sensorimotor and visual stimulation is not large enough to be reliably detected with the current setup and methodology of dynamic 17 O MRI at 7 T.
(© 2023. The Author(s).)
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First implementation of dynamic oxygen-17 ( <superscript>17</superscript> O) magnetic resonance imaging at 7 Tesla during neuronal stimulation in the human brain.
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Autor/in / Beteiligte Person: | Ebersberger, L ; Kratzer, FJ ; Franke, VL ; Nagel, AM ; Niesporek, SC ; Korzowski, A ; Ladd, ME ; Schlemmer, HP ; Paech, D ; Platt, T |
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Zeitschrift: | Magma (New York, N.Y.), Jg. 37 (2024-02-01), Heft 1, S. 27-38 |
Veröffentlichung: | 2003- : Heidelberg : Springer ; <i>Original Publication</i>: New York, NY : Chapman & Hall, c1993-, 2024 |
Medientyp: | academicJournal |
ISSN: | 1352-8661 (electronic) |
DOI: | 10.1007/s10334-023-01119-6 |
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