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Objective: First implementation of dynamic oxygen-17 ( 17 O) MRI at 7 Tesla (T) during neuronal stimulation in the human brain.

Methods: Five healthy volunteers underwent a three-phase 17 O gas ( 17 O 2 ) inhalation experiment. Combined right-side visual stimulus and right-hand finger tapping were used to achieve neuronal stimulation in the left cerebral hemisphere. Data analysis included the evaluation of the relative partial volume (PV)-corrected time evolution of absolute 17 O water (H 2 17 O) concentration and of the relative signal evolution without PV correction. Statistical analysis was performed using a one-tailed paired t test. Blood oxygen level-dependent (BOLD) experiments were performed to validate the stimulation paradigm.

Results: The BOLD maps showed significant activity in the stimulated left visual and sensorimotor cortex compared to the non-stimulated right side. PV correction of 17 O MR data resulted in high signal fluctuations with a noise level of 10% due to small regions of interest (ROI), impeding further quantitative analysis. Statistical evaluation of the relative H 2 17 O signal with PV correction (p = 0.168) and without (p = 0.382) did not show significant difference between the stimulated left and non-stimulated right sensorimotor ROI.

Discussion: The change of cerebral oxygen metabolism induced by sensorimotor and visual stimulation is not large enough to be reliably detected with the current setup and methodology of dynamic 17 O MRI at 7 T.

Titel:	First implementation of dynamic oxygen-17 ( <superscript>17</superscript> O) magnetic resonance imaging at 7 Tesla during neuronal stimulation in the human brain.
Autor/in / Beteiligte Person:	Ebersberger, L ; Kratzer, FJ ; Franke, VL ; Nagel, AM ; Niesporek, SC ; Korzowski, A ; Ladd, ME ; Schlemmer, HP ; Paech, D ; Platt, T
Link:	Full Text Finder (Volltext)
Zeitschrift:	Magma (New York, N.Y.), Jg. 37 (2024-02-01), Heft 1, S. 27-38
Veröffentlichung:	2003- : Heidelberg : Springer ; <i>Original Publication</i>: New York, NY : Chapman & Hall, c1993-, 2024
Medientyp:	academicJournal
ISSN:	1352-8661 (electronic)
DOI:	10.1007/s10334-023-01119-6
Schlagwort:	Humans Oxygen Isotopes Brain Mapping methods Oxygen Brain diagnostic imaging Brain physiology Magnetic Resonance Imaging methods
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [MAGMA] 2024 Feb; Vol. 37 (1), pp. 27-38. <i>Date of Electronic Publication: </i>2023 Sep 22. MeSH Terms: Brain* / diagnostic imaging ; Brain* / physiology ; Magnetic Resonance Imaging* / methods ; Humans ; Oxygen Isotopes ; Brain Mapping / methods ; Oxygen References: MAGMA. 2014 Feb;27(1):95-9. (PMID: 24077796) ; Ann Neurol. 1992 Feb;31(2):119-30. (PMID: 1349466) ; Magn Reson Med. 2009 Dec;62(6):1565-73. (PMID: 19859915) ; Neuroimage. 2019 Feb 15;187:116-127. (PMID: 29544818) ; IEEE Trans Med Imaging. 2001 Jan;20(1):45-57. (PMID: 11293691) ; Magn Reson Med. 2008 Oct;60(4):889-94. (PMID: 18816809) ; MAGMA. 2016 Jun;29(3):617-39. (PMID: 27194154) ; Trends Neurosci. 2002 Jan;25(1):27-31. (PMID: 11801335) ; Magn Reson Med. 2020 Apr;83(4):1512-1518. (PMID: 31593372) ; Radiology. 2020 Apr;295(1):181-189. (PMID: 32068505) ; Neuroimage. 2002 Oct;17(2):825-41. (PMID: 12377157) ; Magn Reson Med. 2021 Apr;85(4):2109-2116. (PMID: 33058265) ; Neurosurg Clin N Am. 2011 Apr;22(2):133-9, vii. (PMID: 21435566) ; World J Radiol. 2014 Jul 28;6(7):437-45. (PMID: 25071884) ; Magn Reson Med. 2011 Oct;66(4):1109-15. (PMID: 21394777) ; Adv Exp Med Biol. 2011;701:215-22. (PMID: 21445790) ; Magn Reson Med. 2003 Jan;49(1):108-14. (PMID: 12509825) ; Neuroimage. 2010 Jun;51(2):723-33. (PMID: 20188194) ; Invest Radiol. 2021 Nov 1;56(11):705-725. (PMID: 34510098) ; Magn Reson Med. 2011 Apr;65(4):1125-30. (PMID: 21413078) ; MAGMA. 2014 Feb;27(1):81-93. (PMID: 24337392) ; Neuroimage. 2016 Nov 1;141:250-261. (PMID: 27364473) ; J Cereb Blood Flow Metab. 2009 Jan;29(1):10-8. (PMID: 18781163) ; MAGMA. 2014 Dec;27(6):579-87. (PMID: 24687775) ; Med Image Anal. 2001 Jun;5(2):143-56. (PMID: 11516708) ; Proc Natl Acad Sci U S A. 1986 Feb;83(4):1140-4. (PMID: 3485282) ; Neuroimage. 2012 Jul 16;61(4):1268-76. (PMID: 22546318) ; Int J Comput Assist Radiol Surg. 2013 Jul;8(4):607-20. (PMID: 23588509) ; Magn Reson Med. 2009 Feb;61(2):354-63. (PMID: 19165897) ; Neurobiol Aging. 2000 May-Jun;21(3):455-62. (PMID: 10858595) ; Front Neurosci. 2023 Jun 15;17:1186558. (PMID: 37404469) ; Neuroimage. 2002 Jun;16(2):531-7. (PMID: 12030835) ; MAGMA. 2013 Aug;26(4):371-5. (PMID: 23292436) ; Neuroimage. 2015 May 15;112:353-363. (PMID: 25797831) ; Vision Res. 1997 Dec;37(24):3593-608. (PMID: 9425533) ; Nat Rev Neurosci. 2006 Sep;7(9):732-44. (PMID: 16924262) ; Neuroimage. 2012 May 1;60(4):2107-17. (PMID: 22487547) ; Front Hum Neurosci. 2017 Aug 18;11:419. (PMID: 28867998) ; Neuroimage. 2000 May;11(5 Pt 1):547-53. (PMID: 10806040) ; Med Image Anal. 2005 Dec;9(6):594-604. (PMID: 15896995) ; Magn Reson Med. 2018 May;79(5):2713-2723. (PMID: 28984056) ; Annu Rev Neurosci. 2014;37:161-81. (PMID: 25032494) ; Magn Reson Med. 2018 Jun;79(6):2923-2934. (PMID: 29030876) Contributed Indexing: Keywords: Cerebral oxygen metabolism; Dynamic oxygen-17 imaging; Neuronal activity; Ultrahigh field MRI; fMRI Substance Nomenclature: 0 (Oxygen-17) ; 0 (Oxygen Isotopes) ; S88TT14065 (Oxygen) Entry Date(s): Date Created: 20230922 Date Completed: 20240221 Latest Revision: 20240222 Update Code: 20240222 PubMed Central ID: PMC10876824

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First implementation of dynamic oxygen-17 ( <superscript>17</superscript> O) magnetic resonance imaging at 7 Tesla during neuronal stimulation in the human brain.