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In this study, we investigated the chemopreventive efficacy of usnic acid (UA), an effective secondary metabolite component of lichens, against 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral squamous cell carcinoma (OSCC) in the hamster model. Initially, the buccal pouch carcinogenesis was induced by administering 0.5% DMBA to the HBP (hamster buccal pouch) region about three times a week until the 10th week. Then, UA was orally treated with different concentrations (25, 50, 100 mg/kg b.wt) on alternative days of DMBA exposure, and the experimental process ended in the 16th week. After animal experimentation, we observed 100% tumor incidence with well-differentiated OSCC, dysplasia, and hyperplasia lesions in the DMBA-induced HBP region. Furthermore, the UA treatment of DMBA-induced hamster effectively inhibited tumor growth. In addition, UA upregulated antioxidant levels, interfered with the elevated lipid peroxidation by-product of thiobarbituric acid reactive substances, and changed the activities of the liver detoxification enzyme (Phase I and II) in DMBA-induced hamsters. Furthermore, immunohistochemical staining of inflammatory markers (iNOS and COX-2) and proliferative cell markers (cyclin-D1 and PCNA) were upregulated in the buccal pouch part of hamster animals induced with DMBA. Notably, the oral administration of UA significantly suppressed these markers during DMBA-induced hamsters. Collectively, our findings revealed that UA exhibits antioxidant, anti-inflammatory, antitumor, and apoptosis-inducing characteristics, demonstrating UA's protective properties against DMBA-induced HBP carcinogenesis.

Titel:	Usnic acid attenuates 7,12-dimethylbenz[a] anthracene (DMBA) induced oral carcinogenesis through inhibiting oxidative stress, inflammation, and cell proliferation in male golden Syrian hamster model.
Autor/in / Beteiligte Person:	Azhamuthu, T ; Kathiresan, S ; Senkuttuvan, I ; Abulkalam Asath, NA ; Ravichandran, P
Link:	Full Text Finder (Volltext)
Zeitschrift:	Journal of biochemical and molecular toxicology, Jg. 38 (2024), Heft 1, S. e23553
Veröffentlichung:	New York, NY : Wiley, c1998-, 2024
Medientyp:	academicJournal
ISSN:	1099-0461 (electronic)
DOI:	10.1002/jbt.23553
Schlagwort:	Cricetinae Animals Male Mesocricetus Antioxidants metabolism 9,10-Dimethyl-1,2-benzanthracene toxicity Carcinogenesis chemically induced Inflammation chemically induced Inflammation drug therapy Oxidative Stress Cell Proliferation Anthracenes Carcinogens toxicity Carcinoma, Squamous Cell chemically induced Mouth Neoplasms chemically induced Mouth Neoplasms prevention & control Mouth Neoplasms pathology Benzofurans
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [J Biochem Mol Toxicol] 2024 Jan; Vol. 38 (1), pp. e23553. <i>Date of Electronic Publication: </i>2023 Oct 16. MeSH Terms: Carcinoma, Squamous Cell* / chemically induced ; Mouth Neoplasms* / chemically induced ; Mouth Neoplasms* / prevention & control ; Mouth Neoplasms* / pathology ; Benzofurans* ; Cricetinae ; Animals ; Male ; Mesocricetus ; Antioxidants / metabolism ; 9,10-Dimethyl-1,2-benzanthracene / toxicity ; Carcinogenesis / chemically induced ; Inflammation / chemically induced ; Inflammation / drug therapy ; Oxidative Stress ; Cell Proliferation ; Anthracenes ; Carcinogens / toxicity References: S. Koontongkaew, J. Cancer 2013, 4, 66. ; H. Sung, J. Ferlay, R. L. Siegel, M. Laversanne, I. Soerjomataram, A. Jemal, F. Bray, CA Cancer J. Clin. 2021, 71, 209. ; V. Kulothungan, K. Sathishkumar, S. Leburu, T. Amamoorthy, S. Stephen, D. Basavarajappa, N. Tomy, R. Mohan, G. R. 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Usnic acid attenuates 7,12-dimethylbenz[a] anthracene (DMBA) induced oral carcinogenesis through inhibiting oxidative stress, inflammation, and cell proliferation in male golden Syrian hamster model.