Einzeltreffer — DigiBib

Regulation of stem cells requires coordination of the cells that make up the stem cell niche. Here, we describe a mechanism that allows communication between niche cells to coordinate their activity and shape the signaling environment surrounding resident stem cells. Using the Drosophila hematopoietic organ, the lymph gland, we show that cells of the hematopoietic niche, the posterior signaling center (PSC), communicate using gap junctions (GJs) and form a signaling network. This network allows PSC cells to exchange Ca 2+ signals repetitively which regulate the hematopoietic niche. Disruption of Ca 2+ signaling in the PSC or the GJ-mediated network connecting niche cells causes dysregulation of the PSC and blood progenitor differentiation. Analysis of PSC-derived cell signaling shows that the Hedgehog pathway acts downstream of GJ-mediated Ca 2+ signaling to modulate the niche microenvironment. These data show that GJ-mediated communication between hematopoietic niche cells maintains their homeostasis and consequently controls blood progenitor behavior.

Titel:	Maintenance of hematopoietic stem cell niche homeostasis requires gap junction-mediated calcium signaling.
Autor/in / Beteiligte Person:	Ho, KYL ; An, K ; Carr, RL ; Dvoskin, AD ; Ou, AYJ ; Vogl, W ; Tanentzapf, G
Link:	Full Text Finder (Volltext)
Zeitschrift:	Proceedings of the National Academy of Sciences of the United States of America, Jg. 120 (2023-11-07), Heft 45, S. e2303018120
Veröffentlichung:	Washington, DC : National Academy of Sciences, 2023
Medientyp:	academicJournal
ISSN:	1091-6490 (electronic)
DOI:	10.1073/pnas.2303018120
Schlagwort:	Animals Hematopoietic Stem Cells metabolism Calcium Signaling Hedgehog Proteins metabolism Drosophila metabolism Cell Differentiation Gap Junctions metabolism Homeostasis Stem Cell Niche Hematopoiesis physiology Drosophila Proteins metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Proc Natl Acad Sci U S A] 2023 Nov 07; Vol. 120 (45), pp. e2303018120. <i>Date of Electronic Publication: </i>2023 Oct 30. MeSH Terms: Drosophila Proteins* / metabolism ; Animals ; Hematopoietic Stem Cells / metabolism ; Calcium Signaling ; Hedgehog Proteins / metabolism ; Drosophila / metabolism ; Cell Differentiation ; Gap Junctions / metabolism ; Homeostasis ; Stem Cell Niche ; Hematopoiesis / physiology References: Biochim Biophys Acta. 2004 Mar 23;1662(1-2):3-21. (PMID: 15033576) ; Nature. 2007 Mar 15;446(7133):320-4. (PMID: 17361183) ; Front Cell Dev Biol. 2020 May 21;8:382. (PMID: 32509789) ; J Physiol. 1993 Dec;472:341-57. (PMID: 8145149) ; Stem Cells. 2014 Apr;32(4):852-9. (PMID: 24356972) ; Genes Dev. 2003 Feb 1;17(3):348-53. (PMID: 12569125) ; Physiol Rev. 2012 Jul;92(3):1359-92. (PMID: 22811430) ; Nat Commun. 2020 Sep 8;11(1):4483. (PMID: 32900993) ; Elife. 2021 Jan 04;10:. (PMID: 33395389) ; Cell. 2008 Feb 22;132(4):598-611. (PMID: 18295578) ; J Biol Chem. 2017 Sep 1;292(35):14473-14485. (PMID: 28726639) ; Adv Exp Med Biol. 2012;740:777-94. (PMID: 22453969) ; Biochem Biophys Res Commun. 2014 Oct 24;453(3):467-72. (PMID: 25280996) ; Nature. 2007 Mar 15;446(7133):325-8. (PMID: 17361184) ; Development. 2014 Sep;141(18):3445-57. (PMID: 25183867) ; Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):E1524-32. (PMID: 23576737) ; Curr Biol. 2021 Nov 8;31(21):4697-4712.e6. (PMID: 34480855) ; Front Immunol. 2021 Aug 16;12:719349. (PMID: 34484226) ; Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4898-903. (PMID: 24707047) ; Development. 2010 Nov;137(21):3561-8. (PMID: 20876645) ; Genes Dev. 2007 Dec 1;21(23):3044-60. (PMID: 18056420) ; Neuroreport. 2015 Oct 21;26(15):928-36. (PMID: 26351758) ; FEBS J. 2009 Apr;276(7):1800-16. (PMID: 19243429) ; Nat Rev Genet. 2004 Feb;5(2):101-13. (PMID: 14735121) ; Development. 2018 Aug 1;145(15):. (PMID: 30068689) ; Phys Biol. 2018 May 16;15(5):051001. (PMID: 29611534) ; Nat Commun. 2016 May 19;7:11634. (PMID: 27193394) ; Biophys J. 2008 Mar 15;94(6):2404-11. (PMID: 18065468) ; Science. 1998 Jan 9;279(5348):227-30. (PMID: 9422695) ; Front Neural Circuits. 2014 Sep 17;8:111. (PMID: 25278844) ; Genetics. 2019 Feb;211(2):367-417. (PMID: 30733377) ; PLoS One. 2012;7(7):e41604. (PMID: 22911822) ; Development. 2005 Jun;132(11):2521-33. (PMID: 15857916) ; Chem Biol. 2005 May;12(5):515-26. (PMID: 15911372) ; Front Physiol. 2018 Oct 11;9:1414. (PMID: 30364195) ; Dev Cell. 2014 Aug 11;30(3):309-21. (PMID: 25065772) ; Cell. 2013 Nov 21;155(5):1141-53. (PMID: 24267893) ; Neuroimage. 2010 Sep;52(3):1059-69. (PMID: 19819337) ; J Neurogenet. 2016 Sep - Dec;30(3-4):185-194. (PMID: 27846759) ; Adv Exp Med Biol. 2010;695:155-68. (PMID: 21222205) ; J Cell Sci. 2022 Jul 15;135(14):. (PMID: 35722729) ; J Neurogenet. 2012 Mar;26(1):89-102. (PMID: 22236090) ; Dev Cell. 2009 May;16(5):756-63. (PMID: 19460351) ; Front Cell Dev Biol. 2021 Oct 13;9:739357. (PMID: 34722521) ; Sci Signal. 2014 Jun 24;7(331):ra59. (PMID: 24962706) ; Elife. 2017 Aug 25;6:. (PMID: 28841136) ; Biophys J. 2019 Feb 19;116(4):725-740. (PMID: 30704858) ; Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):9052-7. (PMID: 26150488) ; Biochim Biophys Acta. 2005 Jun 10;1711(2):225-45. (PMID: 15921654) ; Int J Mol Sci. 2020 Dec 31;22(1):. (PMID: 33396437) ; Development. 2012 May;139(10):1713-7. (PMID: 22510984) ; Biochim Biophys Acta. 2015 Sep;1853(9):2006-11. (PMID: 25896525) ; Sci Rep. 2017 Oct 13;7(1):13115. (PMID: 29030562) ; Biochim Biophys Acta. 2012 Aug;1820(8):1269-82. (PMID: 22100727) ; Adv Exp Med Biol. 2012;740:531-51. (PMID: 22453959) ; Mol Biol Cell. 2006 Apr;17(4):1676-85. (PMID: 16436513) ; Nature. 2015 Dec 10;528(7581):212-7. (PMID: 26633624) ; PLoS One. 2016 Feb 11;11(2):e0148978. (PMID: 26866694) ; Dev Biol. 2008 Mar 1;315(1):232-42. (PMID: 18234173) ; Cell Tissue Res. 2013 Apr;352(1):21-31. (PMID: 22940728) ; Biophys J. 2000 Mar;78(3):1270-81. (PMID: 10692315) ; J Neurogenet. 2018 Sep;32(3):209-220. (PMID: 30175644) ; Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3389-94. (PMID: 22331866) ; Cold Spring Harb Perspect Biol. 2009 Jul;1(1):a002576. (PMID: 20066080) ; Development. 2015 Jul 1;142(13):2261-7. (PMID: 26041767) ; Cell. 2013 Feb 28;152(5):945-56. (PMID: 23452846) ; Neurochem Int. 1996 Feb;28(2):145-53. (PMID: 8719702) Grant Information: 4-Year Doctoral Fellowship University of British Columbia (UBC); PJT-156277 Gouvernement du Canada \| Canadian Institutes of Health Research (IRSC) Contributed Indexing: Keywords: Drosophila; calcium signaling; gap junctions; hematopoiesis; stem cell niche Substance Nomenclature: 0 (Drosophila Proteins) ; 0 (Hedgehog Proteins) Entry Date(s): Date Created: 20231030 Date Completed: 20231102 Latest Revision: 20240501 Update Code: 20240501 PubMed Central ID: PMC10636368

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Maintenance of hematopoietic stem cell niche homeostasis requires gap junction-mediated calcium signaling.