Einzeltreffer — DigiBib

Geographic atrophy (GA) is a prevalent cause of vision loss among elderly and is associated with a significant loss of function. We reviewed the current literature to assess the effect of GA on patients' daily lives and well-being. We record and organize the signs, symptoms, and impacts that are important in life with GA. Further, we examined the impact of GA on vision-related quality of life. The main complaint among patients was difficulties regarding daily tasks, especially reading and other near activities. However, a large proportion of patients also reported fear, frustration, and anxiety as salient symptoms with large impact. Many patients do not have adequate information about their condition as well as the prognosis. The most commonly used measure of patient-reported outcome measure (PROM) is the National Eye Institute Visual Function Questionnaire (VFQ), that reflects the severity of impact on 12 subscales, from where near activities, general vision, mental health, and role difficulties had the lowest scores. Longitudinal studies of GA and the impact of low-vision rehabilitation efforts on health-related quality of life are sparse but suggest a significant improvement on several items. PROM is included in clinical trials, and so far, no drug has shown to improve the functional outcome in terms of PROM.

Titel:	Geographic atrophy - Signs, symptoms, and quality of life.
Autor/in / Beteiligte Person:	Krogh Nielsen, M ; Hinnerskov, JMV ; Sørensen, TL
Link:	Full Text Finder (Volltext)
Zeitschrift:	Acta ophthalmologica, Jg. 101 (2023-12-01), Heft 8, S. 896-902
Veröffentlichung:	Oxford, UK : Wiley-Blackwell ; <i>Original Publication</i>: Oxford, UK ; Malden, MA : Blackwell Munksgaard, 2023
Medientyp:	academicJournal
ISSN:	1755-3768 (electronic)
DOI:	10.1111/aos.15794
Schlagwort:	Humans Aged Sickness Impact Profile Visual Acuity Vision, Ocular Surveys and Questionnaires Quality of Life psychology Geographic Atrophy
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Review Language: English [Acta Ophthalmol] 2023 Dec; Vol. 101 (8), pp. 896-902. MeSH Terms: Quality of Life* / psychology ; Geographic Atrophy* ; Humans ; Aged ; Sickness Impact Profile ; Visual Acuity ; Vision, Ocular ; Surveys and Questionnaires References: Ahluwalia A., Shen L.L. & Del Priore L.V. (2020) Central geographic atrophy vs neovascular age-related macular degeneratio: differences in longitudinal quality of life. Graefes Archives of Clinical and Experimental Ophthalmology, 259, 307-316. ; Bennion, A.E., Shaw, R.L. & Gibson, J.M. (2012) What do we know about the experience of age related macular degeneration? A systematic review and meta-synthesis of qualitative research. Social Science and Medicine, 75, 976-985. ; Boxell, E.M., Amoaku, W.M. & Bradley, C. (2017) Healthcare experiences of patients of age-related macular degeneration: have things improved? Cross-sectional survey responses of macular society members in 2013 compared with 1999. BMJ Open, 7, e012790. ; Braithwaite, T., Calvert, M., Gray, A., Pesudovs, K. & Denniston, A.K. (2019) The use of patient-reported outcome research in modern ophthalmology: impact on clinical trials and routine clinical practice. Patient Related Outcome Measures, 10, 9-24. ; Brown, M.M., Brown, G.C., Sharma, S., Stein, J.D., Roth, Z., Campanella, J. et al. (2006) The burden of age-related macular degeneration: a value-based analysis. Current Opinion in Ophthalmology, 17, 257-266. ; Burguera-Giménez, N., García-Lázaro, S., España-Gregori, E., Gallego-Pinazo, R., Burguera-Giménez, N., Rodríguez-Vallejo, M. et al. (2020) Multimodal evaluation of visual function in geographic atrophy versus normal eyes. Clinical Ophthalmology, 14, 1533-1545. ; Burton, A.E., Shaw, R.L. & Gibson, J.M. (2013) ‘I'd like to know what causes it, you know, anything I've done?’ Are we meeting the information and support needs of patients with macular degeneration? A Qualitative Study. BMJ Open, 3, e003306. ; Carlton, J., Barnes, S. & Haywood, A. (2019) Patient perspectives in geographic atrophy (GA): exploratory qualitative research to understand the impact of GA for patients and their families. The British and Irish Orthoptic Journal, 15, 133-141. ; Christ, S.L., Zheng, D.D., Swenor, B.K., Lam, B.L., West, S.K., Tannenbaum, S.L. et al. (2014) Longitudinal relationships among visual acuity, daily functional status, and mortality: the Salisbury eye evaluation study. JAMA Ophthalmology, 132, 1400-1406. ; Cimarolli, V.R., Boerner, K., Brennan-Ing, M., Reinhardt, J.P. & Horowitz, A. (2012) Challenges faced by older adults with vision loss: a qualitative study with implications for rehabilitation. Clinical Rehabilitation, 26, 748-757. ; Cocce, K.J., Stinnett, S.S., Luhmann, U.F.O., Vajzovic, L., Horne, A., Schuman, S.G. et al. (2018) Visual function metrics in early and intermediate dry age-related macular degeneration for use as clinical trial endpoints. American Journal of Ophthalmology, 189, 127-138. ; Crews, J.E., Jones, G.C. & Kim, J.H. (2006) Double jeopardy: the effects of comorbid conditions among older people with vision loss. Journal of Visual Impairment and Blindness, 100, 824-848. ; DeMuro, C., Clark, M., Doward, L., Evans, E., Mordin, M. & Gnanasakthy, A. (2013) Assessment of PRO label claims granted by the FDA as compared to the EMA (2006-2010). Value in Health, 16, 1150-1155. ; Dhital, A., Pey, T. & Stanford, M.R. (2010) Visual loss and falls: a review. Eye (London, England), 24, 1437-1446. ; El Haj, M., Roche, J., Jardri, R., Kapogiannis, D., Gallouj, K. & Antoine, P. (2017) Clinical and neurocognitive aspects of hallucinations in Alzheimer's disease. Neuroscience and Biobehavioral Reviews, 83, 713-720. ; Erginturk Acar, D., Batioglu, F., Idil, A., Sahli, E. & Goksuluk, D. (2023) Rehabilitation methods for patients with geographic atrophy due to age-related macular degeneration and effects of rehabilitation on quality of life. Journal of Ophthalmology, 2023, 3389750. ; Fleckenstein, M., Mitchell, P., Freund, K.B., Sadda, S., Holz, F.G., Brittain, C. et al. (2018) The progression of geographic atrophy secondary to age-related macular degeneration. Ophthalmology, 125, 369-390. ; Fried, L.P., Ferrucci, L., Darer, J., Williamson, J.D. & Anderson, G. (2004) Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 59, 255-263. ; Fried, L.P., Tangen, C.M., Walston, J., Newman, A.B., Hirsch, C. & Gottdiener, J. (2001) Frailty in older adults: evidence for a phenotype. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 56, 146-156. ; Garrigan, H., Hamati, J., Lalakia, P., Frasso, R., Salzman, B. & Hyman, L. (2022) Does age-related macular degeneration (AMD) treatment influence patient falls and mobility? A systematic review. Ophthalmic Epidemiology, 29, 128-138. ; Goldberg, R., Heier, J.S., Wykoff, C.C., Staurenghi, G., Singh, R.P., Steinle, N. et al. (2022) Efficacy of intravitreal pegcetacoplan in patients with geographic atrophy (GA): 12-month results from the phase 3 OAKS and DERBY studies. Investigative Ophthalmology and Visual Science, 63, 1500. ; Hassell, J.B., Lamoureux, E.L. & Keeffe, J.E. (2006) Impact of age-related macular degeneration on quality of life. The British Journal of Ophthalmology, 90, 593-596. ; Heier, J.S., Pieramici, D., Chakravarthy, U., Patel, S.S., Gupta, S., Lotery, A. et al. (2020) Visual function decline resulting from geographic atrophy: results from the chroma and spectri phase 3 trials. Ophthalmology. Retina, 4, 673-688. ; Holm, D.L., Nielsen, M.K., Højsted, B.B. & Sørensen, T.L. (2023) Vision-related quality of life is selectively affected by comorbidities in patients with geographic atrophy. BMC Ophthalmology, 23, 153. ; Holz, F.G., Strauss, E.C., Schmitz-Valckenberg, S. & van Lookeren, C.M. (2014) Geographic atrophy: clinical features and potential therapeutic approaches. Ophthalmology, 121, 1079-1091. ; Iyigun, E., Bayer, A., Tastan, S., Demiralp, M. & Acikel, C. (2010) Validity and reliability study for the NEI-VFO-39 scale in chronic ophthalmic diseases-Turkish version. Acta Ophthalmologica, 88, e115-e119. ; Jan, T. & Del Castillo, J. (2012) Visual hallucinations: charles bonnet syndrome. The Western Journal of Emergency Medicine, 13, 544-547. ; Künzel, S.H., Möller, P.T., Lindner, M., Goerdt, L., Nadal, J., Schmid, M. et al. (2020) Determinants of quality of life in geographic atrophy secondary to age-related macular degeneration. Investigative Ophthalmology and Visual Science, 61, 63. ; Khanani, A.M., Patel, S.S., Staurenghi, G., Tadayoni, R., Danzig, C.J., Eichenbaum, D.A. et al. (2023) Efficacy and safety of avacincaptad pegol in patients with geographic atrophy (GATHER2): 12-month results from a randomised, double-masked, phase 3 trial. Lancet, 8, S0140-6736. ; Kimel, M., Leidy, N.K., Tschosik, E., Dolan, C., Souied, E.H., Varma, R. et al. (2016) Functional Reading Independence (FRI) index: a new patient-reported outcome measure for patients with geographic atrophy. Investigative Ophthalmology and Visual Science, 57, 6298-6304. ; Lam, B.L., Christ, S.L., Zheng, D.D., West, S.K., Munoz, B.E., Swenor, B.K. et al. (2013) Longitudinal relationships among visual acuity and tasks of everyday life: the Salisbury eye evaluation study. Investigative Ophthalmology and Visual Science, 54, 193-200. ; Lindblad, A.S. & Clemons, T.E. (2005) Responsiveness of the National eye Institute visual function questionnaire to progression to advanced age-related macular degeneration, vision loss, and lens opacity: AREDS report no. 14. Archives of Ophthalmology, 123, 1207-1214. ; Madheswaran, G., Ramesh, S.V., Pardhan, S., Sapkota, R. & Raman, R. (2021) Impact of living with a bilateral central vision loss due to geographic atrophy-qualitative study. BMJ Open, 11, e047861. ; Mangione, C.M. & Berry, S. (1998) Identifying the content area for the 51-item National eye Institute visual functioning questionnaire: results from focus groups with visually impaired persons. Archives of Ophthalmology, 116, 227-233. ; Mangione, C.M., Lee, P.P., Gutierrez, P.R., Spritzer, K., Berry, S., Hays, R.D. et al. (2001) Development of the 25-item National eye Institute visual function questionnaire. Archives of Ophthalmology, 119, 1050-1058. ; Moore, L.W. & Miller, M. (2003) Older men's experiences of living with severe visual impairment. Journal of Advanced Nursing, 43, 10-18. ; Morga, A., Chamberlain, C.X., Meyers, O., Roberts, C., Gaspar, L. & Su, J. (2023) Content validity and cognitive debriefing of a patient-reported outcome instrument evaluating symptoms and disease impact in patients with geographic atrophy. Ophthalmology and Therapy, 12, 1181-1193. ; Nekolova, J., Kremlacek, J., Lukavsky, J., Sikl, R., Sin, M., Langrova, J. et al. (2023) The intraocular implant and visual rehabilitation improve the quality of life of elderly patients with geographic atrophy secondary to age-related macular degeneration. Graefe's Archive for Clinical and Experimental Ophthalmology, 261, 263-272. ; Niazi, S., Krogh Nielsen, M., Singh, A., Sørensen, T.L. & Subhi, Y. (2020) Prevalence of Charles bonnet syndrome in patients with age-related macular degeneration: systematic review and meta-analysis. Acta Ophthalmologica, 98, 121-131. ; Nordmann, J.P., Viala, M., Sullivan, K., Arnould, B. & Berdeaux, G. (2004) Psychometric validation of the National eye Institute visual function questionnaire - 25 (NEI VFQ-25) French version: in a population of patients treated for ocular hypertension and glaucoma. PharmacoEconomics, 22, 197-206. ; Owsley, C., McGwin, G., Scilley, K., Dreer, L.E., Bray, C.R. & Mason, J.O. (2006) Focus groups with persons who have age-related macular degeneration: emotional issues. Rehabilitation Psychology, 5, 23-29. ; Palbo, A., Roed Rasmussen, M.L., Hansen, M.S. & Subhi, Y. (2023) Association between visual impairment and suicide: a systematic review and meta-analysis. Acta Ophthalmologica. Available from: https://doi.org/10.1111/aos.15730. ; Patel, P.J., Ziemssen, F., Ng, E., Muthutantri, A., Silverman, D., Tschosik, E.A. et al. (2020) Burden of illness in geographic atrophy: a study of vision-related quality of life and health care resource use. Clinical Ophthalmology, 14, 15-28. ; Patnaik, J.L., Lynch, A.M., Pecen, P.E., Jasso, M., Hanson, K., Mathias, M.T. et al. (2021) The impact of advanced age-related macular degeneration on the National eye Institute's visual function Questionnaire-25. Acta Ophthalmologica, 99, 750-755. ; Reed-Jones, R.J., Solis, G.R., Lawson, K.A., Loya, A.M., Cude- Islas, D. & Berger, C.S. (2013) Vision and falls: a multidisciplinary review of the contributions of visual impairment to falls among older adults. Maturitas, 75, 22-28. ; Reeves, S., Kuper, A. & Hodges, B.D. (2008) Qualitative research methodologies: ethnography. BMJ, 337, a1020. ; Rossi, G.C., Milano, G. & Tinelli, C. (2003) The Italian version of the 25-item National eye Institute visual function questionnaire: translation, validity, and reliability. Journal of Glaucoma, 12, 213-220. ; Sørensen, M.S., Andersen, S., Henningsen, G.O., Larsen, C.T. & Sørensen, T.L. (2011) Danish version of visual function Questionnaire-25 and its use in age-related macular degeneration. Danish Medical Bulletin, 58, A4290. ; Sadda, S.R., Chakravarthy, U., Birch, D.G., Staurenghi, G., Henry, E.C. & Brittain, C. (2016) Clinical endpoints for the study of geographic atrophy secondary to age-related macular degeneration. Retina, 36, 1806-1822. ; Singh, A. & Sørensen, T.L. (2012) The prevalence and clinical characteristics of Charles bonnet syndrome in Danish patients with neovascular age-related macular degeneration. Acta Ophthalmologica, 90, 476-480. ; Sivaprasad, S., Tschosik, E., Kapre, A., Varma, R., Bressler, N.M., Kimel, M. et al. (2018) Reliability and construct validity of the Nei VFQ-25 in a subset of patients with geographic atrophy from the phase 2 Mahalo study. American Journal of Ophthalmology, 190, 1-8. ; Sivaprasad, S., Tschosik, E.A., Guymer, R.H., Kapre, A., Suñer, I.J., Joussen, A.M. et al. (2019) Living with geographic atrophy: an ethnographic study. Ophthalmology and Therapy, 8, 115-124. ; Stanford, P., Waterman, H.A., Russell, W.B. & Harper, R.E. (2009) Psychological adjustment in age-related macular degeneration. British Journal of Visual Impairment, 27, 129-146. ; Suzukamo, Y., Oshika, T., Yuzawa, M., Tokuda, Y., Tomidokoro, A., Oki, K. et al. (2005) Psychometric properties of the 25-item National eye Institute visual function questionnaire (NEI VFQ-25), Japanese version. Health and Quality of Life Outcomes, 3, 65. ; Taylor, D.J., Hobby, A.E., Binns, A.M. & Crabb, D.P. (2016) How does age-related macular degeneration affect real-world visual ability and quality of life? A systematic review. BMJ Open, 6, e011504. ; Taylor, D.J., Jones, L., Binns, A.M. & Crabb, D.P. (2020) You've got dry macular degeneration, end of story': a qualitative study into the experience of living with non-neovascular age-related macular degeneration. Eye, 34, 461-473. ; U.S. Food and Drug Administration (2009). Available from: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/patient-reported-outcome-measures-use-medical-product-development-support-labeling-claims [Accessed August 2023]. ; U.S. Food and Drug Administration (2020). Available from: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/patient-focused-drug-development-collecting-comprehensive-and-representative-input [Accessed August 2023]. ; Varadaraj, V., Lee, M.J., Tian, J., Ramulu, P.Y., Bandeen-Roche, K. & Swenor, B.K. (2019) Near vision impairment and frailty: evidence of an association. American Journal of Ophthalmology, 208, 234-241. ; Vukicevic, M. & Fitzmaurice, K. (2008) Butterflies and black lacy patterns: the prevalence and characteristics of Charles bonnet hallucinations in an Australian population. Clinical & Experimental Ophthalmology, 36, 659-665. ; Whittal, A., Meregaglia, M. & Nicod, E. (2021) The use of patient-reported outcome measures in rare diseases and implications for health technology assessment. Patient, 14, 485-503. ; Wood, J.M., Lacherez, P., Black, A.A., Cole, M.H., Boon, M.Y. & Kerr, G.K. (2011) Risk of falls, injurious falls, and other injuries resulting from visual impairment among older adults with age-related macular degeneration. Investigative Ophthalmology and Visual Science, 52, 5088-5092. ; World Health Organization. (2021) Falls. Available from: https://www.who.int/news-room/fact-sheets/detail/falls [Accessed August 2023]. Contributed Indexing: Keywords: age-related macular degeneration; geographic atrophy; patient-reported outcome measures; quality of life; symptoms Entry Date(s): Date Created: 20231107 Date Completed: 20231108 Latest Revision: 20231108 Update Code: 20240514

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

Geographic atrophy - Signs, symptoms, and quality of life.