Evaluation of a new point-of-care diagnostic test measuring inflammation in emergency settings.
In: Scientific reports, Jg. 13 (2023-11-09), Heft 1, S. 19551
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Zugriff:
Erythrocyte aggregation kinetics is accelerated in diseases with a strong inflammation component. This study aimed to evaluate whether, in an emergency setting, a new point-of-care test measuring erythrocyte aggregation kinetics (EAK) can identify patients with underlying inflammation. Patients visiting an emergency department and needing a blood exam were successively included. EAK was measured at the point-of-care in 20 s directly on the blood samples collected in regular tubes without any manipulation. The primary measure was EAK's half-life during the first 5 s (EAK5s). Each patient's inflammation status was assessed blind to the EAK test results. Receiver Operating Characteristic (ROC) curves for inflammation status were built. 268 patients had their EAK5s measured, and a clear inflammation status was determined for 214 patients (65 had inflammation). Mean EAK5s were 2.18 s and 1.75 s for no inflammation and inflammation groups respectively (p < 0.001). EAK5s appears to be a better inflammation marker than C-Reactive protein (CRP), with an area under the ROC curve of 0.845 compared to 0.806 for CRP (p < 0.0001). The Youden threshold for prediction of inflammation was 1.86 s with 84.6% (78.5-89.9%) specificity and 70.8% (60-81.5%) sensitivity. Point-of-care EAK is an easily measured, immediately available marker of inflammation with a better predictive power than CRP's.
(© 2023. The Author(s).)
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Evaluation of a new point-of-care diagnostic test measuring inflammation in emergency settings.
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Autor/in / Beteiligte Person: | Charansonney, OL ; Al-Dandachi, G ; Plaisance, P ; Vicaut, E |
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Zeitschrift: | Scientific reports, Jg. 13 (2023-11-09), Heft 1, S. 19551 |
Veröffentlichung: | London : Nature Publishing Group, copyright 2011-, 2023 |
Medientyp: | academicJournal |
ISSN: | 2045-2322 (electronic) |
DOI: | 10.1038/s41598-023-46347-x |
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