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Plasmodium falciparum erythrocyte binding antigen 175 (PfEBA-175) plays essential role in erythrocyte invasion by the parasite and is a leading vaccine candidate. However, its genetic diversity in global isolates is a concern in developing an universal vaccine incorporating this protein. This study aimed to investigate genetic polymorphisms and natural selection of pfeba-175 region II (RII) in Myanmar and Vietnam P. falciparum isolates. Vietnam pfeba-175 RII displayed a low genetic polymorphism, while Myanmar pfeba-175 RII showed high levels of genetic diversity across the region. Point mutations, deletion, and recombinations were main factors contributing to genetic diversities in P. falciparum populations. Global pfeba-175 RII revealed similar, but not identical, genetic polymorphisms and natural selection profiles. Despite profiles of amino acid substitutions differed among populations, five major amino acid changes (K279E, E403K, K481I, Q584K, and R664) were commonly detected in global pfeba-175 RII populations. Haplotype network and genetic differentiation analyses of global pfeba-175 RII populations demonstrated no geographical relationships. Non-neglectable level of genetic diversity was observed in global pfeba-175 RII populations, emphasizing the need to consider this when designing an effective vaccine based on this protein. This study underscores the importance of the continuous monitoring of genetic diversity of pfeba-175 RII in the global P. falciparum populations.

Titel:	Genetic polymorphism and natural selection of the erythrocyte binding antigen 175 region II in Plasmodium falciparum populations from Myanmar and Vietnam.
Autor/in / Beteiligte Person:	Võ, TC ; Lê, HG ; Kang, JM ; Naw, H ; Yoo, WG ; Myint, MK ; Quang, HH ; Na, BK
Link:	Full Text Finder (Volltext)
Zeitschrift:	Scientific reports, Jg. 13 (2023-11-16), Heft 1, S. 20025
Veröffentlichung:	London : Nature Publishing Group, copyright 2011-, 2023
Medientyp:	academicJournal
ISSN:	2045-2322 (electronic)
DOI:	10.1038/s41598-023-47275-6
Schlagwort:	Humans Plasmodium falciparum metabolism Myanmar Vietnam Protozoan Proteins metabolism Antigens, Protozoan Polymorphism, Genetic Selection, Genetic Erythrocytes metabolism Genetic Variation Malaria, Falciparum parasitology Vaccines
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Sci Rep] 2023 Nov 16; Vol. 13 (1), pp. 20025. <i>Date of Electronic Publication: </i>2023 Nov 16. MeSH Terms: Malaria, Falciparum* / parasitology ; Vaccines* ; Humans ; Plasmodium falciparum / metabolism ; Myanmar ; Vietnam ; Protozoan Proteins / metabolism ; Antigens, Protozoan ; Polymorphism, Genetic ; Selection, Genetic ; Erythrocytes / metabolism ; Genetic Variation References: Cell. 2005 Jul 29;122(2):183-93. (PMID: 16051144) ; Mol Biol Evol. 2013 Dec;30(12):2725-9. (PMID: 24132122) ; Malar J. 2017 Mar 16;16(1):119. (PMID: 28302168) ; Malar J. 2011 Dec 17;10:371. (PMID: 22177111) ; Malar J. 2021 Sep 19;20(1):374. (PMID: 34538247) ; Elife. 2017 Feb 22;6:. (PMID: 28226242) ; Infect Genet Evol. 2020 Nov;85:104418. (PMID: 32561295) ; Mol Biol Evol. 1999 Jan;16(1):37-48. (PMID: 10331250) ; Am J Trop Med Hyg. 2022 Oct 11;107(4_Suppl):138-151. (PMID: 36228909) ; Bioinformatics. 2009 Jun 1;25(11):1451-2. (PMID: 19346325) ; Science. 1994 Jun 24;264(5167):1941-4. (PMID: 8009226) ; Malar J. 2019 Nov 19;18(1):367. (PMID: 31744492) ; Mol Ecol. 2005 Jul;14(8):2611-20. (PMID: 15969739) ; Cold Spring Harb Perspect Med. 2017 Jul 5;7(7):. (PMID: 28289248) ; Malar J. 2018 Oct 12;17(1):361. (PMID: 30314440) ; Malar J. 2018 Feb 07;17(1):71. (PMID: 29415731) ; Cell Host Microbe. 2017 Aug 9;22(2):232-245. (PMID: 28799908) ; Malar J. 2020 May 19;19(1):184. (PMID: 32429986) ; Mol Ecol. 2014 Apr;23(8):1979-93. (PMID: 24834503) ; PLoS Pathog. 2013;9(5):e1003390. (PMID: 23717209) ; Malar J. 2010 May 17;9:131. (PMID: 20478015) ; Infect Immun. 2000 Oct;68(10):5559-66. (PMID: 10992454) ; Trends Parasitol. 2004 Aug;20(8):388-95. (PMID: 15246323) ; Malar J. 2019 Jul 16;18(1):241. (PMID: 31311565) ; Parasitol Int. 2021 Aug;83:102374. (PMID: 33957296) ; Genes (Basel). 2021 Nov 27;12(12):. (PMID: 34946853) ; PLoS One. 2013;8(2):e56326. (PMID: 23457550) ; Mol Ecol Resour. 2010 May;10(3):564-7. (PMID: 21565059) ; Mol Biol Evol. 1986 Sep;3(5):418-26. (PMID: 3444411) ; J Cell Biol. 1990 Nov;111(5 Pt 1):1877-84. (PMID: 2229177) ; Mol Ecol Resour. 2017 Jan;17(1):27-32. (PMID: 26850166) ; Infect Genet Evol. 2018 Jan;57:64-74. (PMID: 29128519) ; Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):7085-9. (PMID: 1496004) ; Microorganisms. 2022 Oct 13;10(10):. (PMID: 36296297) ; J Immunol. 2013 Jul 15;191(2):785-94. (PMID: 23776178) ; Pathogens. 2021 Jul 21;10(8):. (PMID: 34451379) ; Korean J Parasitol. 2018 Apr;56(2):153-165. (PMID: 29742870) ; Mol Biochem Parasitol. 1993 Apr;58(2):283-92. (PMID: 8479452) Substance Nomenclature: 0 (Protozoan Proteins) ; 0 (Antigens, Protozoan) ; 0 (Vaccines) Entry Date(s): Date Created: 20231117 Date Completed: 20231120 Latest Revision: 20231124 Update Code: 20240513 PubMed Central ID: PMC10654615

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Genetic polymorphism and natural selection of the erythrocyte binding antigen 175 region II in Plasmodium falciparum populations from Myanmar and Vietnam.