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Purpose: The heart is a highly aerobic organ consuming most of the oxygen the body in supporting heart function. Quantitative imaging of myocardial oxygen metabolism and perfusion is essential for studying cardiac physiopathology in vivo. Here, we report a new imaging method that can simultaneously assess myocardial oxygen metabolism and blood flow in the rat heart.

Methods: This novel method is based on the 17 O-MRSI combined with brief inhalation of 17 O-isotope labeled oxygen gas for quantitative imaging of myocardial metabolic rate of oxygen consumption (MVO 2 ), myocardial blood flow (MBF), and oxygen extraction fraction (OEF). We demonstrate this imaging method under basal and high workload conditions in rat hearts at 9.4 T.

Results: We show that this 17 O MRSI-based approach can directly measure and image MVO 2 (1.35-4.06 μmol/g/min), MBF (0.49-1.38 mL/g/min), and OEF (0.33-0.44) in the heart of anesthetized rat under basal and high workload (21.6 × 10 3 -56.7 × 10 3 mmHg • bpm) conditions. Under high workload condition, MVO 2 and MBF values in healthy rats approximately doubled, whereas OEF remained unchanged, indicating a strong coupling between myocardial oxygen metabolic demand and supply through blood perfusion.

Conclusion: The 17 O-MRSI method has been used to simultaneously image the myocardial metabolic rate of oxygen consumption, blood flow, and oxygen extraction fraction in small animal hearts, which are sensitive to the physiological changes induced by high workload. This approach could provide comprehensive measures that are critical for studying myocardial function in normal and diseased states and has a potential for translation.

Titel:	Quantitative <superscript>17</superscript> O MRSI of myocardial oxygen metabolic rate, blood flow, and oxygen extraction fraction under normal and high workload conditions.
Autor/in / Beteiligte Person:	Zhu, XH ; Chen, W
Link:	Full Text Finder (Volltext)
Zeitschrift:	Magnetic resonance in medicine, Jg. 91 (2024-04-01), Heft 4, S. 1645-1658
Veröffentlichung:	1999- : New York, NY : Wiley ; <i>Original Publication</i>: San Diego : Academic Press,, 2024
Medientyp:	academicJournal
ISSN:	1522-2594 (electronic)
DOI:	10.1002/mrm.29908
Schlagwort:	Rats Animals Coronary Circulation Myocardium metabolism Heart diagnostic imaging Oxygen Consumption Oxygen Workload
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Magn Reson Med] 2024 Apr; Vol. 91 (4), pp. 1645-1658. <i>Date of Electronic Publication: </i>2023 Dec 12. MeSH Terms: Oxygen* ; Workload* ; Rats ; Animals ; Coronary Circulation ; Myocardium / metabolism ; Heart / diagnostic imaging ; Oxygen Consumption References: Cardiovasc Res. 2017 Mar 15;113(4):411-421. (PMID: 28395011) ; Biochim Biophys Acta. 2016 Oct;1861(10):1425-33. (PMID: 26993579) ; J Cereb Blood Flow Metab. 2013 Dec;33(12):1846-9. (PMID: 24064490) ; Circ Cardiovasc Imaging. 2011 Nov;4(6):678-84. (PMID: 21926262) ; J Appl Physiol (1985). 2018 Jan 1;124(1):168-181. (PMID: 28473616) ; Magn Reson Med. 2010 Jun;63(6):1442-7. (PMID: 20512845) ; Phys Med Biol. 1999 Mar;44(3):781-99. (PMID: 10211810) ; Circ Res. 2013 Aug 16;113(5):603-16. (PMID: 23948585) ; Stroke. 1984 Jan-Feb;15(1):129-33. (PMID: 6695417) ; J Nucl Med. 2006 Mar;47(3):477-85. (PMID: 16513617) ; Magn Reson Med. 2018 Dec;80(6):2717-2725. (PMID: 29770486) ; Physiol Rev. 2008 Jul;88(3):1009-86. (PMID: 18626066) ; Annu Rev Physiol. 1974;36:413-59. (PMID: 19400669) ; Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13194-9. (PMID: 12242341) ; J Nucl Cardiol. 2021 Apr;28(2):768-787. (PMID: 33786730) ; Neuroimage. 2010 Jun;51(2):723-33. (PMID: 20188194) ; Circulation. 1996 Aug 15;94(4):808-16. (PMID: 8772705) ; J Cardiovasc Magn Reson. 2014 Feb 18;16:18. (PMID: 24548535) ; Diabetes. 2007 Oct;56(10):2457-66. (PMID: 17623815) ; MAGMA. 2014 Feb;27(1):95-9. (PMID: 24077796) ; Basic Res Cardiol. 2014 Jul;109(4):413. (PMID: 24866583) ; J Magn Reson Imaging. 2005 Aug;22(2):242-7. (PMID: 16028244) ; Circ Res. 2022 Jun 10;130(12):1851-1868. (PMID: 35679370) ; Magn Reson Med. 2001 Apr;45(4):543-9. (PMID: 11283979) ; Circulation. 1996 Aug 15;94(4):792-807. (PMID: 8772704) ; Circ Res. 1978 Mar;42(3):394-401. (PMID: 624146) ; Magn Reson Med. 2013 Jun;69(6):1523-7. (PMID: 22777729) ; Front Physiol. 2019 Jun 19;10:741. (PMID: 31275160) ; J Cereb Blood Flow Metab. 2009 Jan;29(1):10-8. (PMID: 18781163) ; Int J Physiol Pathophysiol Pharmacol. 2014 Dec 15;6(4):209-15. (PMID: 25755842) ; NMR Biomed. 2012 Jun;25(6):883-9. (PMID: 22161858) ; Circ Res. 1958 Sep;6(5):612-23. (PMID: 13573592) ; J Nucl Med. 1991 Nov;32(11):2169-75. (PMID: 1941156) ; IEEE Trans Med Imaging. 2021 Dec;40(12):3879-3890. (PMID: 34319872) ; J Nucl Med. 1984 Feb;25(2):177-87. (PMID: 6610032) ; J Toxicol Pathol. 2013 Mar;26(1):29-34. (PMID: 23723565) ; Ultrasound Med Biol. 2002 Apr;28(4):459-66. (PMID: 12049959) ; Physiol Rev. 2005 Jul;85(3):1093-129. (PMID: 15987803) ; Neuroimage. 2013 Jan 1;64:437-47. (PMID: 23000789) ; J Cereb Blood Flow Metab. 2004 Aug;24(8):840-8. (PMID: 15362714) ; Circulation. 1988 Jul;78(1):104-15. (PMID: 3260151) ; Semin Nucl Med. 2004 Apr;34(2):87-111. (PMID: 15031810) ; J Magn Reson B. 1994 Nov;105(3):225-32. (PMID: 7850168) ; Anal Biochem. 2017 Jul 15;529:171-178. (PMID: 27568551) ; Magn Reson Med. 2021 Apr;85(4):2232-2246. (PMID: 33104248) ; Magn Reson Med. 2021 Dec;86(6):2899-2909. (PMID: 34231258) ; Neuroimage. 2012 May 1;60(4):2107-17. (PMID: 22487547) ; Am J Physiol Heart Circ Physiol. 2005 Jan;288(1):H310-6. (PMID: 15374825) ; Magn Reson Med. 2013 Aug;70(2):309-14. (PMID: 23001743) ; Magn Reson Med. 2018 Jun;79(6):2923-2934. (PMID: 29030876) Grant Information: R01 MH111413 United States MH NIMH NIH HHS; P41 EB027061 United States NH NIH HHS; R01 NS133006 United States NH NIH HHS; R01 MH111413 United States NH NIH HHS; R01 NS133006 United States NS NINDS NIH HHS; P41 EB027061 United States EB NIBIB NIH HHS Contributed Indexing: Keywords: high workload; in vivo oxygen-17 (17O) MRS imaging (MRSI); myocardial blood flow; myocardial energy metabolism; myocardial metabolic rate of oxygen consumption; oxygen extraction fraction Substance Nomenclature: S88TT14065 (Oxygen) Entry Date(s): Date Created: 20231212 Date Completed: 20240205 Latest Revision: 20240514 Update Code: 20240514 PubMed Central ID: PMC11089813

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Quantitative <superscript>17</superscript> O MRSI of myocardial oxygen metabolic rate, blood flow, and oxygen extraction fraction under normal and high workload conditions.