Correlation study between bone metabolic markers, bone mineral density, and sarcopenia.
In: Journal of endocrinological investigation, Jg. 47 (2024-06-01), Heft 6, S. 1559-1572
Online
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Zugriff:
Objective: To investigate the correlation between bone metabolism markers, bone mineral density (BMD), and sarcopenia.
Methods: A total of 331 consecutive patients aged ≥ 60 years who were hospitalized between November 2020 and December 2021 were enrolled. Participants were divided into sarcopenia and non-sarcopenia groups according to the Asian Working Group on Sarcopenia criteria (AWGS, 2019). The clinical data, bone metabolism markers (β-CTX, N-MID, and TP1NP), and BMD were compared between the two groups.
Results: Age, β-CTX, and N-MID of the sarcopenia group were higher than those of the non-sarcopenia group (P < 0.05), but the BMD T values were lower than those of the non-sarcopenia group (P < 0.05). Binary logistic regression analysis showed that increased femoral neck BMD (FNBMD) was a protective factor for sarcopenia, while increased β-CTX was a risk factor. Pearson/Spearman correlation analysis showed that the diagnostic indices of sarcopenia were positively correlated with FNBMD and negatively correlated with β-CTX and N-MID. Multiple linear regression analysis revealed that BMI and FNBMD significantly positively affected muscle strength and appendicular skeletal muscle mass (ASM). The FNBMD significantly positively affected physical performance, while β-CTX significantly negatively affected muscle strength, ASM, and physical performance.
Conclusion: Increased FNBMD may be a protective factor against sarcopenia, and increased β-CTX may be a risk factor. The FNBMD significantly positively affected the diagnostic indices of sarcopenia, while β-CTX significantly negatively affected them. BMD and bone metabolism marker levels may be considered in early screening for sarcopenia.
(© 2023. The Author(s), under exclusive licence to Italian Society of Endocrinology (SIE).)
Titel: |
Correlation study between bone metabolic markers, bone mineral density, and sarcopenia.
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Autor/in / Beteiligte Person: | Xie, WQ ; He, M ; Yu, DJ ; Li, HZ ; Jin, HF ; Ji, BZ ; Yang, G ; Chen, LL ; Rahmati, M ; Li, YS |
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Zeitschrift: | Journal of endocrinological investigation, Jg. 47 (2024-06-01), Heft 6, S. 1559-1572 |
Veröffentlichung: | 2014- : Berlin : Springer ; <i>Original Publication</i>: Milano, Published for the Italian Society of Endocrinology by Editrice Kurtis., 2024 |
Medientyp: | academicJournal |
ISSN: | 1720-8386 (electronic) |
DOI: | 10.1007/s40618-023-02252-8 |
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