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Objective: To investigate the correlation between bone metabolism markers, bone mineral density (BMD), and sarcopenia.

Methods: A total of 331 consecutive patients aged ≥ 60 years who were hospitalized between November 2020 and December 2021 were enrolled. Participants were divided into sarcopenia and non-sarcopenia groups according to the Asian Working Group on Sarcopenia criteria (AWGS, 2019). The clinical data, bone metabolism markers (β-CTX, N-MID, and TP1NP), and BMD were compared between the two groups.

Results: Age, β-CTX, and N-MID of the sarcopenia group were higher than those of the non-sarcopenia group (P < 0.05), but the BMD T values were lower than those of the non-sarcopenia group (P < 0.05). Binary logistic regression analysis showed that increased femoral neck BMD (FNBMD) was a protective factor for sarcopenia, while increased β-CTX was a risk factor. Pearson/Spearman correlation analysis showed that the diagnostic indices of sarcopenia were positively correlated with FNBMD and negatively correlated with β-CTX and N-MID. Multiple linear regression analysis revealed that BMI and FNBMD significantly positively affected muscle strength and appendicular skeletal muscle mass (ASM). The FNBMD significantly positively affected physical performance, while β-CTX significantly negatively affected muscle strength, ASM, and physical performance.

Conclusion: Increased FNBMD may be a protective factor against sarcopenia, and increased β-CTX may be a risk factor. The FNBMD significantly positively affected the diagnostic indices of sarcopenia, while β-CTX significantly negatively affected them. BMD and bone metabolism marker levels may be considered in early screening for sarcopenia.

Titel:	Correlation study between bone metabolic markers, bone mineral density, and sarcopenia.
Autor/in / Beteiligte Person:	Xie, WQ ; He, M ; Yu, DJ ; Li, HZ ; Jin, HF ; Ji, BZ ; Yang, G ; Chen, LL ; Rahmati, M ; Li, YS
Link:	Full Text Finder (Volltext)
Zeitschrift:	Journal of endocrinological investigation, Jg. 47 (2024-06-01), Heft 6, S. 1559-1572
Veröffentlichung:	2014- : Berlin : Springer ; <i>Original Publication</i>: Milano, Published for the Italian Society of Endocrinology by Editrice Kurtis., 2024
Medientyp:	academicJournal
ISSN:	1720-8386 (electronic)
DOI:	10.1007/s40618-023-02252-8
Schlagwort:	Humans Female Male Aged Middle Aged Procollagen blood Muscle, Skeletal metabolism Peptide Fragments blood Collagen Type I blood Bone and Bones metabolism Muscle Strength physiology Sarcopenia diagnosis Sarcopenia metabolism Bone Density physiology Biomarkers analysis
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [J Endocrinol Invest] 2024 Jun; Vol. 47 (6), pp. 1559-1572. <i>Date of Electronic Publication: </i>2023 Dec 14. MeSH Terms: Sarcopenia* / diagnosis ; Sarcopenia* / metabolism ; Bone Density* / physiology ; Biomarkers* / analysis ; Humans ; Female ; Male ; Aged ; Middle Aged ; Procollagen / blood ; Muscle, Skeletal / metabolism ; Peptide Fragments / blood ; Collagen Type I / blood ; Bone and Bones / metabolism ; Muscle Strength / physiology Comments: Erratum in: J Endocrinol Invest. 2024 Feb 19;:. (PMID: 38374491) References: Cruz-Jentoft AJ et al (2019) Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing 48(1):16–31. (PMID: 3031237210.1093/ageing/afy169) ; Cruz-Jentoft AJ et al (2010) Sarcopenia: European consensus on definition and diagnosis: report of the European working group on sarcopenia in older people. Age Ageing 39(4):412–423. 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(PMID: 2868976810.1016/S2213-8587(17)30184-5) Grant Information: 82072506 National Natural Science Foundation of China; 92268115 National Natural Science Foundation of China Contributed Indexing: Keywords: Bone metabolism marker; Bone mineral density; Muscle mass; Muscle strength; Physical performance; Sarcopenia Substance Nomenclature: 0 (Biomarkers) ; 0 (Procollagen) ; 0 (Peptide Fragments) ; 0 (Collagen Type I) Entry Date(s): Date Created: 20231214 Date Completed: 20240531 Latest Revision: 20240531 Update Code: 20240601

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Correlation study between bone metabolic markers, bone mineral density, and sarcopenia.