Utility of liver stiffness measurement in the diagnosis of sinusoidal obstruction syndrome/veno-occlusive disease after hematopoietic stem cell transplantation.

Inoue, Y ; Saitoh, S ; et al.

In: Journal of medical ultrasonics (2001), Jg. 51 (2024-04-01), Heft 2, S. 311-321

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Purpose: We aimed to assess the role of liver stiffness measurement (LSM), evaluated using transient elastography (TE), for the diagnosis of sinusoidal obstruction syndrome (SOS)/veno-occlusive disease (VOD), a complication of hematopoietic stem cell transplantation (HSCT).

Methods: In this retrospective study, ultrasonography (US) and LSM were performed on 86 adult patients (55 men and 31 women) undergoing HSCT between January 2016 and December 2022. Characteristics and changes in liver stiffness (LS) were compared between patients with and without SOS/VOD.

Results: Of the 86 patients, 14 were diagnosed with SOS/VOD. A significant increase in LS (ranging from 12.6 to 55.1 kPa, median 23.8 kPa) compared to pre-HSCT values was observed in all patients who developed SOS/VOD. The area under the receiver operating characteristic curve (AUROC) for the diagnosis of SOS/VOD was 0.9663 (0.933-0.995) for LS ≥ 17.4 kPa after HSCT. Post-transplant LS exceeded 17.4 kPa in all 14 patients in the SOS/VOD group (100%) and in seven patients in the non-SOS/VOD group (9.7%). The sensitivity and specificity were 100% and 90.3%, respectively. AUROC for the diagnosis of SOS/VOD was 0.973 (0.943-1.000) for LS increase ≥ + 12.6 kPa from baseline after HSCT. The change of ≥ + 12.6 kPa from baseline was observed in all 14 patients in the SOS/VOD group (100%) and in four patients in the non-SOS/VOD group (5.6%). The sensitivity and specificity were 100% and 94.4%, respectively.

Conclusion: LSM using TE may contribute to establishing the diagnosis of SOS/VOD after HSCT.

Titel:	Utility of liver stiffness measurement in the diagnosis of sinusoidal obstruction syndrome/veno-occlusive disease after hematopoietic stem cell transplantation.
Autor/in / Beteiligte Person:	Inoue, Y ; Saitoh, S ; Denpo, H ; Yamaguchi, K ; Kubota, K ; Taya, Y ; Wake, A ; Masuda, A ; Ishiwata, K
Link:	Full Text Finder (Volltext)
Zeitschrift:	Journal of medical ultrasonics (2001), Jg. 51 (2024-04-01), Heft 2, S. 311-321
Veröffentlichung:	Tokyo, Japan : Springer Verlag, c2001-, 2024
Medientyp:	academicJournal
ISSN:	1613-2254 (electronic)
DOI:	10.1007/s10396-023-01392-x
Schlagwort:	Humans Male Female Retrospective Studies Adult Middle Aged Young Adult Adolescent Aged ROC Curve Hepatic Veno-Occlusive Disease diagnostic imaging Hepatic Veno-Occlusive Disease etiology Hematopoietic Stem Cell Transplantation adverse effects Elasticity Imaging Techniques methods Liver diagnostic imaging
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [J Med Ultrason (2001)] 2024 Apr; Vol. 51 (2), pp. 311-321. <i>Date of Electronic Publication: </i>2023 Dec 19. MeSH Terms: Hepatic Veno-Occlusive Disease* / diagnostic imaging ; Hepatic Veno-Occlusive Disease* / etiology ; Hematopoietic Stem Cell Transplantation* / adverse effects ; Elasticity Imaging Techniques* / methods ; Liver* / diagnostic imaging ; Humans ; Male ; Female ; Retrospective Studies ; Adult ; Middle Aged ; Young Adult ; Adolescent ; Aged ; ROC Curve References: Contributed Indexing: Keywords: Hematopoietic stem cell transplantation (HSCT); Liver stiffness (LS); Sinusoidal obstruction syndrome (SOS); Transient elastography (TE); Veno-occlusive disease (VOD) Entry Date(s): Date Created: 20231219 Date Completed: 20240516 Latest Revision: 20240516 Update Code: 20240516

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