Type 17-specific immune pathways are active in early spondyloarthritis.
In: RMD open, Jg. 9 (2023-12-20), Heft 4
Online
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Zugriff:
Objective: Undifferentiated, early inflammatory arthritis (EIA) can differentiate into seropositive or seronegative rheumatoid arthritis (RA), peripheral spondyloarthritis (SpA) or remain as seronegative undifferentiated inflammatory arthritis (UIA). Little is known about immune pathways active in the early stages of SpA and seronegative UIA, in contrast to detailed knowledge of seropositive RA. The aim of this study was to examine if specific immune pathways were active in synovial CD4+ and CD8+ T cells in EIA.
Methods: Synovial fluid (SF) samples from 30 patients with EIA were analysed for expression of IL-17A, IFNγ and TNFα in CD8+ or CD4+ T cells. Final clinical diagnoses were made at least 12 months after sample collection, by two independent clinicians blind to the study data.
Results: Flow cytometry analysis of all EIA samples indicated considerable variation in synovial IL-17A+CD8+ T cells (Tc17) cell frequencies between patients. The group with a final diagnosis of SpA (psoriatic arthritis or peripheral SpA, n=14) showed a significant enrichment in the percentage of synovial Tc17 cells compared with the group later diagnosed with seronegative UIA (n=10). The small number of patients later diagnosed with seropositive RA (n=6) patients had few Tc17 cells, similar to our previous findings in established disease. In contrast, RA SF contained a significantly higher percentage of CD8+IFNγ+ T cells compared with SpA or seronegative UIA.
Conclusion: These results suggest that adaptive T cell cytokine pathways differ not only between RA and SpA but also seronegative UIA early in the disease process, with a particular activation of Tc17 pathways in early SpA.
Competing Interests: Competing interests: BWK has received consultancy and speaker fees from Abbvie, Eli Lilly, Pfizer, Novartis and UCB. LST previously received research support from Novartis, UCB, Sanofi and GSK outside the work described in this manuscript.
(© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY. Published by BMJ.)
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Type 17-specific immune pathways are active in early spondyloarthritis.
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| Autor/in / Beteiligte Person: | Hughes, CD ; Ryan, SE ; Steel, KJA ; van den Beukel MD ; Trouw, LA ; van Schie KAJ ; Toes, REM ; Menon, B ; Kirkham, BW ; Taams, LS |
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| Zeitschrift: | RMD open, Jg. 9 (2023-12-20), Heft 4 |
| Veröffentlichung: | London : BMJ Publishing Group, [2015]-, 2023 |
| Medientyp: | academicJournal |
| ISSN: | 2056-5933 (electronic) |
| DOI: | 10.1136/rmdopen-2023-003328 |
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