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In the artificial breeding of Pampus argenteus (Euphrasen, 1788), female fish spawn before male release sperm, which indicates rapid ovarian development. In fish, aromatase is responsible for converting androgens into estrogens and estrogen plays a crucial role in ovarian development. In this study, we aimed to investigate the potential role of brain-type and ovarian-type aromatase to study the rapid ovarian development mechanism. The results showed that cyp19a1a was mainly expressed in the ovary and could be classified as the ovarian type, whereas cyp19a1b could be considered as the brain type for its expression was mainly in the brain. During ovarian development, the expression of cyp19a1a in the ovary significantly increased from stage IV to stage V and Cyp19a1a signals were present in the follicle cells, while cyp19a1b expression in the pituitary gland decreased from stage IV to stage V. To further investigate the function of Cyp19a1a, recombinant Cyp19a1a (rCyp19a1a) was produced and specific anti-Cyp19a1a antiserum was obtained. The expressions of cyp19a1a , estrogen receptors 2 alpha ( esr2a ), and androgen receptor alpha ( arα ) were significantly upregulated in the presence of rCyp19a1a. Meanwhile, cyp19a1a was expressed significantly after E2 treatment in both ovarian and testicular tissue culture. Taken together, we found two forms of aromatase in silver pomfret. The ovarian-type aromatase might play an important role in ovarian differentiation and maturation, and participate in E2 synthesis through co-regulation with esr2a. The brain-type aromatase cyp19a1b might be involved in the regulation of both brain and gonadal development.

Titel:	Cyp19a1a Promotes Ovarian Maturation through Regulating E2 Synthesis with Estrogen Receptor 2a in Pampus argenteus (Euphrasen, 1788).
Autor/in / Beteiligte Person:	Guo, C ; Zhang, K ; Li, C ; Xing, R ; Xu, S ; Wang, D ; Wang, X
Link:	Full Text Finder (Volltext)
Zeitschrift:	International journal of molecular sciences, Jg. 25 (2024-01-27), Heft 3
Veröffentlichung:	Basel, Switzerland : MDPI, [2000-, 2024
Medientyp:	academicJournal
ISSN:	1422-0067 (electronic)
DOI:	10.3390/ijms25031583
Schlagwort:	Animals Male Female Aromatase metabolism Semen metabolism Ovary metabolism Estrogens metabolism Fishes metabolism Estrogen Receptor alpha genetics Estrogen Receptor alpha metabolism Receptors, Estrogen genetics Receptors, Estrogen metabolism Perciformes metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Int J Mol Sci] 2024 Jan 27; Vol. 25 (3). <i>Date of Electronic Publication: </i>2024 Jan 27. MeSH Terms: Receptors, Estrogen* / genetics ; Receptors, Estrogen* / metabolism ; Perciformes* / metabolism ; Animals ; Male ; Female ; Aromatase / metabolism ; Semen / metabolism ; Ovary / metabolism ; Estrogens / metabolism ; Fishes / metabolism ; Estrogen Receptor alpha / genetics ; Estrogen Receptor alpha / metabolism References: Biol Reprod. 2001 Oct;65(4):1186-94. (PMID: 11566742) ; Mol Cell Endocrinol. 2004 Apr 30;219(1-2):83-94. (PMID: 15149730) ; Gene. 2022 Nov 15;843:146795. (PMID: 35961435) ; Tissue Cell. 2019 Jun;58:70-75. (PMID: 31133248) ; Gen Comp Endocrinol. 2010 Feb 1;165(3):367-89. (PMID: 19505465) ; Anim Reprod Sci. 2024 Feb;261:107373. (PMID: 38211439) ; Ecotoxicol Environ Saf. 2017 Oct;144:45-53. (PMID: 28601516) ; PeerJ. 2019 Jun 11;7:e7032. (PMID: 31218121) ; Saudi J Biol Sci. 2021 Oct;28(10):5808-5815. (PMID: 34588895) ; Cytogenet Genome Res. 2003;101(3-4):289-94. (PMID: 14684997) ; Comp Biochem Physiol B Biochem Mol Biol. 2005 May;141(1):49-59. (PMID: 15820134) ; Gen Comp Endocrinol. 2020 May 15;291:113395. (PMID: 31981691) ; Mol Cell Endocrinol. 2018 Jan 15;460:104-122. (PMID: 28711606) ; J Genet. 2014 Aug 19;93(2):e89-93. (PMID: 25201833) ; Endocrinology. 2017 Aug 1;158(8):2634-2647. (PMID: 28838139) ; Front Neuroendocrinol. 2010 Apr;31(2):203-16. (PMID: 20176046) ; Comp Biochem Physiol A Mol Integr Physiol. 2011 Nov;160(3):374-80. (PMID: 21782032) ; PLoS One. 2017 Oct 10;12(10):e0185864. (PMID: 29016690) ; J Steroid Biochem Mol Biol. 2001 Dec;79(1-5):305-14. (PMID: 11850237) ; Anim Genet. 2003 Feb;34(1):62-4. (PMID: 12580790) ; Gen Comp Endocrinol. 2005 Apr;141(2):101-15. (PMID: 15748711) ; J Steroid Biochem Mol Biol. 2004 Sep;92(1-2):39-50. (PMID: 15544929) ; Gene Expr Patterns. 2005 Jun;5(5):655-67. (PMID: 15939378) ; Gen Comp Endocrinol. 2019 Sep 15;281:17-29. (PMID: 31085192) ; BMC Biol. 2006 Jun 06;4:16. (PMID: 16756667) ; Genesis. 2009 May;47(5):289-99. (PMID: 19298014) ; Mol Cell Endocrinol. 2012 Jun 5;356(1-2):31-9. (PMID: 21856374) ; Dev Growth Differ. 2008 Jun;50 Suppl 1:S195-219. (PMID: 18482399) ; Annu Rev Physiol. 2002;64:93-127. (PMID: 11826265) ; Fish Physiol Biochem. 2020 Oct;46(5):1809-1824. (PMID: 32557081) ; Sci Rep. 2016 Nov 23;6:37357. (PMID: 27876832) ; Endocrinology. 2004 Jun;145(6):2968-77. (PMID: 15001543) ; Front Endocrinol (Lausanne). 2018 May 09;9:230. (PMID: 29867763) ; J Steroid Biochem Mol Biol. 2002 Sep;82(1):19-32. (PMID: 12429136) ; Gene. 2019 Aug 20;710:307-315. (PMID: 31125733) ; Gene Expr Patterns. 2016 Jan;20(1):42-54. (PMID: 26611722) ; Mol Reprod Dev. 2001 Aug;59(4):359-70. (PMID: 11468772) ; Gene. 2015 Apr 25;561(1):6-14. (PMID: 25550048) ; J Endocrinol. 2008 Nov;199(2):317-31. (PMID: 18728127) ; Endocrinology. 2001 Feb;142(2):740-50. (PMID: 11159846) ; Mol Reprod Dev. 2011 Jul;78(7):510-8. (PMID: 21656871) ; Biol Reprod. 2014 Aug;91(2):29. (PMID: 24943038) ; Gen Comp Endocrinol. 2012 Sep 15;178(3):529-38. (PMID: 22814335) ; Cell Tissue Res. 2022 Aug;389(2):259-287. (PMID: 35552517) ; J Mol Endocrinol. 1992 Feb;8(1):53-61. (PMID: 1543534) ; Reproduction. 2001 May;121(5):685-95. (PMID: 11427156) ; Biol Reprod. 2008 Feb;78(2):333-41. (PMID: 17942796) ; Gen Comp Endocrinol. 2006 Jan 15;145(2):197-207. (PMID: 16213504) ; Gen Comp Endocrinol. 2010 Feb 1;165(3):352-66. (PMID: 19289125) ; Endocrinology. 2013 Aug;154(8):2881-90. (PMID: 23744638) ; Gen Comp Endocrinol. 2015 Sep 15;221:120-33. (PMID: 26144886) ; Front Endocrinol (Lausanne). 2023 Jun 23;14:1225199. (PMID: 37435485) ; Biol Reprod. 2009 May;80(5):889-96. (PMID: 19129512) ; Mol Cell Endocrinol. 2003 Jun 30;204(1-2):169-77. (PMID: 12850291) Grant Information: none Ningbo University Talent Introduction Research Initiation Fund Project (Natural Science Category); none KC Wong Magna Fund in Ningbo University Contributed Indexing: Keywords: Cyp19a1a; Pampus argenteus; aromatase; estrogen receptor; hormone Substance Nomenclature: 0 (Receptors, Estrogen) ; EC 1.14.14.1 (Aromatase) ; 0 (Estrogens) ; 0 (Estrogen Receptor alpha) Entry Date(s): Date Created: 20240210 Date Completed: 20240214 Latest Revision: 20240214 Update Code: 20240214 PubMed Central ID: PMC10855460

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Cyp19a1a Promotes Ovarian Maturation through Regulating E2 Synthesis with Estrogen Receptor 2a in Pampus argenteus (Euphrasen, 1788).