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Purpose: To develop and validate a nomogram for the preoperative diagnosis of T2 and T3 stage rectal cancer using MRI radiomics features of mesorectal fat.

Methods: The data of 288 patients with T2 and T3 stage rectal cancer were retrospectively collected. Radiomics features were extracted from the lesion region of interest (ROI) in the MRI high-resolution T2WI, apparent diffusion coefficient (ADC), and diffusion-weighted imaging (DWI) sequences. After using ICC inter-group consistency analysis and Pearson correlation analysis to reduce dimensions, LASSO regression analysis was performed to select features and calculate Rad-score for each sequence. Then, Combined_Radscore and nomogram were constructed based on the LASSO-selected features and clinical data for each sequence. Receiver operating characteristic curve (ROC) area under the curve (AUC) was used to evaluate the performance of the Rad-score model and nomogram. Decision curve analysis (DCA) was performed to evaluate the clinical usability of the radiomics nomogram, which were combined with calibration curves to evaluate the prediction accuracy.

Results: The nomogram based on MRI-report T status and Combined_Radscore achieved AUCs of 0.921 and 0.889 in the training and validation cohorts, respectively.

Conclusion: The nomogram can be stated that the radiomics nomogram based on multi-sequence MRI imaging of the mesorectal fat has excellent diagnosing performance for preoperative differentiation of T2 and T3 stage rectal cancer.

Titel:	A nomogram based on MRI radiomics features of mesorectal fat for diagnosing T2- and T3-stage rectal cancer.
Autor/in / Beteiligte Person:	Deng, B ; Wang, Q ; Liu, Y ; Yang, Y ; Gao, X ; Dai, H
Link:	Full Text Finder (Volltext)
Zeitschrift:	Abdominal radiology (New York), Jg. 49 (2024-06-01), Heft 6, S. 1850-1860
Veröffentlichung:	[New York] : Springer, [2016]-, 2024
Medientyp:	academicJournal
ISSN:	2366-0058 (electronic)
DOI:	10.1007/s00261-023-04164-w
Schlagwort:	Humans Male Female Middle Aged Retrospective Studies Aged Adult Adipose Tissue diagnostic imaging Radiomics Rectal Neoplasms diagnostic imaging Rectal Neoplasms pathology Nomograms Magnetic Resonance Imaging methods Neoplasm Staging
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Abdom Radiol (NY)] 2024 Jun; Vol. 49 (6), pp. 1850-1860. <i>Date of Electronic Publication: </i>2024 Feb 13. MeSH Terms: Rectal Neoplasms* / diagnostic imaging ; Rectal Neoplasms* / pathology ; Nomograms* ; Magnetic Resonance Imaging* / methods ; Neoplasm Staging* ; Humans ; Male ; Female ; Middle Aged ; Retrospective Studies ; Aged ; Adult ; Adipose Tissue / diagnostic imaging ; Radiomics References: Papaccio F, Roselló S, Huerta M, et al. Neoadjuvant Chemotherapy in Locally Advanced Rectal Cancer. Cancers (Basel). 2020 Dec 3;12(12):3611. (PMID: 10.3390/cancers12123611332871147761666) ; Horvat N, Carlos Tavares Rocha C, Clemente Oliveira B, et al. MRI of Rectal Cancer: Tumor Staging, Imaging Techniques, and Management. Radiographics. 2019 Mar-Apr;39(2):367-387. (PMID: 10.1148/rg.201918011430768361) ; Qian Pei, Yi Xiaoping, Chen Chen, et al. 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(PMID: 10.1186/s12885-021-08773-w345653388474828) Contributed Indexing: Keywords: Magnetic resonance imaging; Mesorectal fat; Radiomics; Rectal cancer Entry Date(s): Date Created: 20240213 Date Completed: 20240628 Latest Revision: 20240628 Update Code: 20240628

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A nomogram based on MRI radiomics features of mesorectal fat for diagnosing T2- and T3-stage rectal cancer.