Einzeltreffer — DigiBib

Abstract: Leptomeningeal carcinomatosis in prostate cancer is extremely rare. Because of the low overall penetration of drugs into the brain and the prolonged survival of castration-resistant prostate cancer (CRPC) patients, a special attention should be paid to the appearance of neurological symptoms in long-term CRPC survivors. A patient suffering from a CRPC with bone metastases underwent 4 cycles of 177 Lu-PSMA (prostate-specific membrane antigen)-617. Starting from the third cycle, he reported an increasing feeling of a permanent hangover. A 68 Ga-PSMA-11 brain PET/MRI was carried out after the fourth cycle. It revealed intraparenchymatous brain metastases with intense uptake and evidences of leptomeningeal carcinomatosis.

Competing Interests: Conflicts of interest and sources of funding: none declared.

Titel:	A Hangover Under 177 Lu-PSMA-617 Therapy : A Red Flag for Brain 68 Ga-PSMA-11 PET/MRI?
Autor/in / Beteiligte Person:	Poterszman, N ; Somme, L ; Bund, C ; Hutt, E ; Somme, F
Zeitschrift:	Clinical nuclear medicine, Jg. 49 (2024-06-01), Heft 6, S. 582-583
Veröffentlichung:	Philadelphia, Lippincott., 2024
Medientyp:	academicJournal
ISSN:	1536-0229 (electronic)
DOI:	10.1097/RLU.0000000000005126
Schlagwort:	Humans Male Dipeptides Heterocyclic Compounds, 1-Ring Multimodal Imaging Edetic Acid analogs & derivatives Aged Prostatic Neoplasms, Castration-Resistant diagnostic imaging Radioisotopes Brain Neoplasms diagnostic imaging Brain Neoplasms secondary Brain diagnostic imaging Gallium Isotopes Gallium Radioisotopes Magnetic Resonance Imaging Lutetium Positron-Emission Tomography Prostate-Specific Antigen
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Case Reports Language: English [Clin Nucl Med] 2024 Jun 01; Vol. 49 (6), pp. 582-583. <i>Date of Electronic Publication: </i>2024 Feb 23. MeSH Terms: Gallium Isotopes* ; Gallium Radioisotopes* ; Magnetic Resonance Imaging* ; Lutetium* ; Positron-Emission Tomography* ; Prostate-Specific Antigen* ; Humans ; Male ; Dipeptides ; Heterocyclic Compounds, 1-Ring ; Multimodal Imaging ; Edetic Acid / analogs & derivatives ; Aged ; Prostatic Neoplasms, Castration-Resistant / diagnostic imaging ; Radioisotopes ; Brain Neoplasms / diagnostic imaging ; Brain Neoplasms / secondary ; Brain / diagnostic imaging References: Tannock IF, de Wit R, Berry WR, et al. Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer. N Engl J Med . 2004;351:1502–1512. ; Yust-Katz S, Mathis S, Groves MD. Leptomeningeal metastases from genitourinary cancer: the University of Texas MD Anderson Cancer Center experience. Med Oncol . 2013;30:429. ; Taylor HG, Lefkowitz M, Skoog SJ, et al. Intracranial metastases in prostate cancer. Cancer . 1984;53:2728–2730. ; Gupta R, Wang L, Wang J, et al. Intracranial meningeal carcinomatosis in metastatic castration resistant prostate cancer: will extension of survival increase the incidence? Clin Genitourin Cancer . 2012;10:271–273. ; Fizazi K, Tran N, Fein L, et al. Abiraterone plus prednisone in metastatic, castration-sensitive prostate cancer. N Engl J Med . 2017;377:352–360. ; Davis ID, Martin AJ, Stockler MR, et al. Enzalutamide with standard first-line therapy in metastatic prostate cancer. N Engl J Med . 2019;381:121–131. ; Sartor O, de Bono J, Chi KN, et al. Lutetium-177-PSMA-617 for metastatic castration-resistant prostate cancer. N Engl J Med . 2021;385:1091–1103. ; Caffo O, Gernone A, Ortega C, et al. Central nervous system metastases from castration-resistant prostate cancer in the docetaxel era. J Neurooncol . 2012;107:191–196. ; Nakasu Y, Deguchi S, Nakasu S, et al. Diagnostic accuracy of cerebrospinal fluid liquid biopsy and MRI for leptomeningeal metastases in solid cancers: a systematic review and meta-analysis. Neurooncol Adv . 2023;5:vdad002. ; Zhao G, Ji B. Head-to-head comparison of 68 Ga-PSMA-11 PET/CT and 99m Tc-MDP bone scintigraphy for the detection of bone metastases in patients with prostate cancer: a meta-analysis. AJR Am J Roentgenol . 2022;219:386–395. ; Yin C, Ho B, Chan L, et al. Asymptomatic prostate cancer brain metastases on 68 Ga-PSMA PET/CT. Clin Nucl Med . 2019;44:e382–e384. Substance Nomenclature: 0 (Gallium Isotopes) ; 0 (gallium 68 PSMA-11) ; 0 (Gallium Radioisotopes) ; 5H0DOZ21UJ (Lutetium) ; 0 (Dipeptides) ; 0 (Heterocyclic Compounds, 1-Ring) ; 9G34HU7RV0 (Edetic Acid) ; 0 (Radioisotopes) ; BRH40Y9V1Q (Lutetium-177) ; 0 (PSMA-617) ; 0 (Pluvicto) ; 0 (PSMA-11) ; EC 3.4.21.77 (Prostate-Specific Antigen) Entry Date(s): Date Created: 20240223 Date Completed: 20240505 Latest Revision: 20240505 Update Code: 20240505

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

A Hangover Under 177 Lu-PSMA-617 Therapy : A Red Flag for Brain 68 Ga-PSMA-11 PET/MRI?