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Background/aim: Fat grafting has been widely used for soft-tissue augmentation. External volume expansion (EVE) is a favorable tool for improvement in the rate of fat graft retention. However, few studies have focused on the most appropriate time for its implementation. In this study, BALB/c nude mice were used to investigate the effective time for the implementation of external volume expansion to improve the rate of fat retention.

Materials and Methods: Sixteen mice were divided into four groups, and EVE was performed at different time points before or both before and after fat grafting. Fat tissue from a human donor was injected into the mice following EVE. Visual assessment, micro-computed tomography analysis, and histopathological evaluation were used to assess fat retention.

Results: After 10 weeks, the group that underwent EVE 5 days before fat grafting demonstrated a significantly higher preserved fat volume, as determined by micro-computed tomography (p<0.05). Moreover, the group that received additional EVE after fat grafting exhibited a higher retention rate compared to the groups receiving EVE only before grafting (p<0.05). Histopathological analysis indicated that swelling, edema, and inflammation were more pronounced in the group with EVE immediately before grafting, while angiogenesis and lipogenesis were more active in the group with additional EVE after grafting.

Conclusion: EVE is a safe and effective approach for improving the rate of fat graft retentions. Furthermore, the timing of external tissue expansion plays a crucial role in fat retention. Based on our animal study, performing EVE immediately before and after fat grafting may be an effective strategy for enhancing the rate of fat graft retentions.

Titel:	External Volume Expansion: Timing and Effects on the Rate of Fat Graft Retention in BALB/c Nude Mice.
Autor/in / Beteiligte Person:	Chang, YJ ; Kim, YH ; Lee, JS ; Ryu, JY ; Choi, KY ; Chung, HY ; Cho, BC ; Yang, JD
Zeitschrift:	In vivo (Athens, Greece), Jg. 38 (2024-03-01), Heft 2, S. 710-718
Veröffentlichung:	<2000- > : Attiki, Greece : International Institute of Anticancer Research ; <i>Original Publication</i>: Athens : Dr. J.G. Delinassios, 2024
Medientyp:	academicJournal
ISSN:	1791-7549 (electronic)
DOI:	10.21873/invivo.13492
Schlagwort:	Animals Mice Humans Mice, Nude X-Ray Microtomography Graft Survival Adipose Tissue transplantation Inflammation
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [In Vivo] 2024 Mar-Apr; Vol. 38 (2), pp. 710-718. MeSH Terms: Adipose Tissue* / transplantation ; Inflammation* ; Animals ; Mice ; Humans ; Mice, Nude ; X-Ray Microtomography ; Graft Survival References: Acta Biomed. 2019 May 23;90(2):197-208. (PMID: 31124996) ; Plast Reconstr Surg. 2002 Apr 1;109(4):1344-51. (PMID: 11964989) ; Plast Reconstr Surg. 2010 Nov;126(5):1528-1538. (PMID: 21042110) ; Ann Plast Surg. 2009 Aug;63(2):124-7. (PMID: 19574890) ; Plast Reconstr Surg. 2014 Oct;134(4):675-683. (PMID: 24945949) ; Plast Reconstr Surg. 2014 Nov;134(5):951-959. (PMID: 25054244) ; Plast Reconstr Surg. 2012 Sep;130(3):511-522. (PMID: 22929236) ; Plast Reconstr Surg. 2013 Sep;132(3):569-578. (PMID: 23676966) ; Plast Reconstr Surg. 2020 Jan;145(1):103-112. (PMID: 31577660) ; Plast Reconstr Surg. 2007 Mar;119(3):775-85; discussion 786-7. (PMID: 17312477) ; Plast Reconstr Surg. 2015 Apr;135(4):1045-1055. (PMID: 25502860) ; Plast Reconstr Surg. 2015 May;135(5):933e-935e. (PMID: 25700295) ; Indian J Plast Surg. 2016 May-Aug;49(2):151-158. (PMID: 27833274) ; Plast Reconstr Surg. 2000 Mar;105(3):964-71. (PMID: 10724256) ; Br J Plast Surg. 2001 Jan;54(1):1-7. (PMID: 11121309) ; Plast Reconstr Surg. 2007 Nov;120(6):1680-1689. (PMID: 18040206) ; Plast Reconstr Surg. 2014 Aug;134(2):227-232. (PMID: 25068323) ; Plast Reconstr Surg. 1994 Sep;94(3):496-506. (PMID: 8047602) ; Aesthetic Plast Surg. 1994 Winter;18(1):17-9. (PMID: 8122571) ; Plast Reconstr Surg. 2017 Apr;139(4):882-890. (PMID: 28350665) ; Plast Reconstr Surg. 2012 Jul;130(1):249-258. (PMID: 22743888) ; J Plast Reconstr Aesthet Surg. 2008 Jul;61(7):792-8. (PMID: 18321802) ; J Plast Reconstr Aesthet Surg. 2008 Dec;61(12):1425-37. (PMID: 18835232) ; Chin Med J (Engl). 2019 Sep 20;132(18):2223-2228. (PMID: 31490259) Contributed Indexing: Keywords: BALB/c nude mice; external volume expansion; fat graft; fat retention rate Entry Date(s): Date Created: 20240228 Date Completed: 20240301 Latest Revision: 20240304 Update Code: 20240304 PubMed Central ID: PMC10905471

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External Volume Expansion: Timing and Effects on the Rate of Fat Graft Retention in BALB/c Nude Mice.