Einzeltreffer — DigiBib

Protein and nucleic acid methylation are important biochemical modifications. In addition to their well-established roles in gene regulation, they also regulate cell signaling, metabolism, and translation. Despite this high biological relevance, little is known about the general regulation of methyltransferase function. Methyltransferases are divided into superfamilies based on structural similarities and further classified into smaller families based on sequence/domain/target similarity. While members within superfamilies differ in substrate specificity, their structurally similar active sites indicate a potential for shared modes of regulation. Growing evidence from one superfamily suggests a common regulatory mode may be through heterooligomerization with other family members. Here, we describe examples of methyltransferase regulation through intrafamily heterooligomerization and discuss how this can be exploited for therapeutic use.

Titel:	Intrafamily heterooligomerization as an emerging mechanism of methyltransferase regulation.
Autor/in / Beteiligte Person:	Hobble, HV ; Schaner Tooley, CE
Link:	Full Text Finder (Volltext)
Zeitschrift:	Epigenetics & chromatin, Jg. 17 (2024-03-01), Heft 1, S. 5
Veröffentlichung:	[London] : BioMed Central, 2024
Medientyp:	academicJournal
ISSN:	1756-8935 (electronic)
DOI:	10.1186/s13072-024-00530-0
Schlagwort:	Humans Amino Acid Sequence Methylation Catalytic Domain Methyltransferases metabolism Proteins metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Review Language: English [Epigenetics Chromatin] 2024 Mar 01; Vol. 17 (1), pp. 5. <i>Date of Electronic Publication: </i>2024 Mar 01. MeSH Terms: Methyltransferases* / metabolism ; Proteins* / metabolism ; Humans ; Amino Acid Sequence ; Methylation ; Catalytic Domain References: Arch Biochem Biophys. 2016 Jan 15;590:138-152. (PMID: 26612103) ; J Biol Chem. 2023 Apr;299(4):104588. (PMID: 36889590) ; Mol Cell Proteomics. 2011 Jan;10(1):M110.000976. (PMID: 20930037) ; Medchemcomm. 2014 Dec 19;5(12):1779-1788. (PMID: 26693001) ; Biochem J. 2018 Oct 22;475(20):3201-3219. (PMID: 30242065) ; Nat Commun. 2020 Jul 3;11(1):3355. (PMID: 32620778) ; Stem Cell Rev Rep. 2023 Jan;19(1):76-91. (PMID: 36094754) ; BMC Mol Cell Biol. 2019 Aug 5;20(1):29. (PMID: 31382872) ; Life (Basel). 2021 Nov 19;11(11):. (PMID: 34833139) ; Nucleic Acids Res. 2023 Dec 11;51(22):12476-12491. 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Intrafamily heterooligomerization as an emerging mechanism of methyltransferase regulation.