Clinical parameters and inflammatory biomarkers among patients with multibracket appliances: a prospective clinical trial.
In: BMC oral health, Jg. 24 (2024-03-05), Heft 1, S. 308
Online
academicJournal
Zugriff:
Background: Aim of the presented study was to investigate changes in clinical parameters and active matrix metalloproteinase-8 (aMMP-8) levels in gingival crevicular fluid of patients before and during treatment with multibrackets appliances.
Methods: Fifty-five adolescents scheduled for the treatment were included. Clinical parameters and subgingival samples were obtained at six time points: 1 week before appliance insertion (T0), 3 (T1), 6 (T2) weeks, 3 (T3), 6 (T4) months, and 1 year (T5) after that. Gingival index and plaque index were assessed to evaluated changes on the clinical status. Subgingival samples were collected to analyze changes in aMMP-8.
Results: Scores for gingival and plaque index increased after bracket insertion. The gingival index increased from T2 (p < 0.05) until T5 (p < 0.0001). Plaque index also increased, reaching its maximum peak at T3 (p < 0.05). Moreover, an increase of aMMP-8 levels (p < 0.05) was noted. There was no significant between upper and lower jaws.
Conclusions: Treatment with multibracket appliances in adolescents favors dental plaque accumulation and may transitionally increase gingival and plaque index and aMMP-8 levels leading to gingival inflammation, even 1 year after therapy began.
Trial Registration: This study was approved by the Ethics Committee of the dental medical association Rheiland-Pfalz, Germany (process no. 837.340.12 (8441-F)), and followed the guidelines of Good Clinical Practices.
(© 2024. The Author(s).)
Titel: |
Clinical parameters and inflammatory biomarkers among patients with multibracket appliances: a prospective clinical trial.
|
---|---|
Autor/in / Beteiligte Person: | Peron, PF ; Wehrbein, H ; Mundethu, A ; Schmidtmann, I ; Erbe, C |
Link: | |
Zeitschrift: | BMC oral health, Jg. 24 (2024-03-05), Heft 1, S. 308 |
Veröffentlichung: | London : BioMed Central, [2001-, 2024 |
Medientyp: | academicJournal |
ISSN: | 1472-6831 (electronic) |
DOI: | 10.1186/s12903-024-03995-3 |
Schlagwort: |
|
Sonstiges: |
|