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Background: Aim of the presented study was to investigate changes in clinical parameters and active matrix metalloproteinase-8 (aMMP-8) levels in gingival crevicular fluid of patients before and during treatment with multibrackets appliances.

Methods: Fifty-five adolescents scheduled for the treatment were included. Clinical parameters and subgingival samples were obtained at six time points: 1 week before appliance insertion (T0), 3 (T1), 6 (T2) weeks, 3 (T3), 6 (T4) months, and 1 year (T5) after that. Gingival index and plaque index were assessed to evaluated changes on the clinical status. Subgingival samples were collected to analyze changes in aMMP-8.

Results: Scores for gingival and plaque index increased after bracket insertion. The gingival index increased from T2 (p < 0.05) until T5 (p < 0.0001). Plaque index also increased, reaching its maximum peak at T3 (p < 0.05). Moreover, an increase of aMMP-8 levels (p < 0.05) was noted. There was no significant between upper and lower jaws.

Conclusions: Treatment with multibracket appliances in adolescents favors dental plaque accumulation and may transitionally increase gingival and plaque index and aMMP-8 levels leading to gingival inflammation, even 1 year after therapy began.

Trial Registration: This study was approved by the Ethics Committee of the dental medical association Rheiland-Pfalz, Germany (process no. 837.340.12 (8441-F)), and followed the guidelines of Good Clinical Practices.

Titel:	Clinical parameters and inflammatory biomarkers among patients with multibracket appliances: a prospective clinical trial.
Autor/in / Beteiligte Person:	Peron, PF ; Wehrbein, H ; Mundethu, A ; Schmidtmann, I ; Erbe, C
Link:	Full Text Finder (Volltext)
Zeitschrift:	BMC oral health, Jg. 24 (2024-03-05), Heft 1, S. 308
Veröffentlichung:	London : BioMed Central, [2001-, 2024
Medientyp:	academicJournal
ISSN:	1472-6831 (electronic)
DOI:	10.1186/s12903-024-03995-3
Schlagwort:	Adolescent Humans Prospective Studies Biomarkers Dental Plaque Index Germany Patients
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [BMC Oral Health] 2024 Mar 05; Vol. 24 (1), pp. 308. <i>Date of Electronic Publication: </i>2024 Mar 05. MeSH Terms: Patients* ; Adolescent ; Humans ; Prospective Studies ; Biomarkers ; Dental Plaque Index ; Germany References: Int J Dent Hyg. 2008 May;6(2):129-36. (PMID: 18412726) ; Sci Rep. 2020 Aug 10;10(1):13471. (PMID: 32778676) ; Am J Orthod Dentofacial Orthop. 2009 Jan;135(1):95-8. (PMID: 19121507) ; Clin Lab. 2013;59(5-6):605-11. (PMID: 23865360) ; Acta Odontol Scand. 1966 Dec;24(6):747-59. (PMID: 5228803) ; Am J Orthod Dentofacial Orthop. 2010 Feb;137(2):223-8. (PMID: 20152679) ; Minerva Stomatol. 2018 Jun;67(3):129-138. (PMID: 29879804) ; Diagnostics (Basel). 2020 Aug 05;10(8):. (PMID: 32764436) ; Angle Orthod. 2016 Nov;86(6):998-1003. (PMID: 26606331) ; BMC Oral Health. 2018 Aug 3;18(1):130. (PMID: 30075780) ; Schweiz Monatsschr Zahnmed. 2011;121(11):1041-51. 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(PMID: 31979091) ; Angle Orthod. 2012 Jul;82(4):748-53. (PMID: 22044115) Contributed Indexing: Keywords: Dental plaque; Gingivitis; MMP8; Orthodontics; aMMP8 Substance Nomenclature: 0 (Biomarkers) Entry Date(s): Date Created: 20240305 Date Completed: 20240307 Latest Revision: 20240308 Update Code: 20240308 PubMed Central ID: PMC10913366

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Clinical parameters and inflammatory biomarkers among patients with multibracket appliances: a prospective clinical trial.