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Siglec-9/E is a cell surface receptor expressed on immune cells and can be activated by sialoglycan ligands to play an immunosuppressive role. Our previous study showed that increasing the expression of Siglec-9 (the human paralog of mouse Siglec-E) ligands maintains functionally quiescent immune cells in the bloodstream, but the biological effects of Siglec-9 ligand alteration on atherogenesis were not further explored. In the present study, we demonstrated that the atherosclerosis risk factor ox-LDL or a high-fat diet could decrease the expression of Siglec-9/E ligands on erythrocytes. Increased expression of Siglec-E ligands on erythrocytes caused by dietary supplementation with glucose (20% glucose) had anti-inflammatory effects, and the mechanism was associated with glucose intake. In high-fat diet-fed apoE -/- mice, glucose supplementation decreased the area of atherosclerotic lesions and peripheral inflammation. These data suggested that increased systemic inflammation is attenuated by increasing the expression of Siglec-9/E ligands on erythrocytes. Therefore, Siglec-9/E ligands might be valuable targets for atherosclerosis therapy.

Titel:	Supplementing Glucose Intake Reverses the Inflammation Induced by a High-Fat Diet by Increasing the Expression of Siglec-E Ligands on Erythrocytes.
Autor/in / Beteiligte Person:	Liu, H ; Li, J ; Wu, N ; She, Y ; Luo, Y ; Huang, Y ; Quan, H ; Fu, W ; Li, X ; Zeng, D ; Jia, Y
Link:	Full Text Finder (Volltext)
Zeitschrift:	Inflammation, Jg. 47 (2024-04-01), Heft 2, S. 609-625
Veröffentlichung:	1999- : New York, NY : Kluwer Academic/Plenum Publishers ; <i>Original Publication</i>: New York, Plenum Press., 2024
Medientyp:	academicJournal
ISSN:	1573-2576 (electronic)
DOI:	10.1007/s10753-023-01932-0
Schlagwort:	Animals Mice Ligands Atherosclerosis metabolism Atherosclerosis prevention & control Antigens, CD metabolism Dietary Supplements Male Mice, Inbred C57BL Diet, High-Fat adverse effects Sialic Acid Binding Immunoglobulin-like Lectins metabolism Inflammation metabolism Erythrocytes metabolism Erythrocytes drug effects Glucose metabolism Antigens, Differentiation, B-Lymphocyte
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Inflammation] 2024 Apr; Vol. 47 (2), pp. 609-625. <i>Date of Electronic Publication: </i>2024 Mar 07. MeSH Terms: Diet, High-Fat* / adverse effects ; Sialic Acid Binding Immunoglobulin-like Lectins* / metabolism ; Inflammation* / metabolism ; Erythrocytes* / metabolism ; Erythrocytes* / drug effects ; Glucose* / metabolism ; Antigens, Differentiation, B-Lymphocyte* ; Animals ; Mice ; Ligands ; Atherosclerosis / metabolism ; Atherosclerosis / prevention & control ; Antigens, CD / metabolism ; Dietary Supplements ; Male ; Mice, Inbred C57BL References: Kolaczkowska, E., and P. Kubes. 2013. Neutrophil recruitment and function in health and inflammation. Nature Reviews Immunology 13: 159–175. https://doi.org/10.1038/nri3399 . (PMID: 10.1038/nri339923435331) ; Zhou, M.G., H.D. Wang, X.Y. Zeng, P. Yin, J. Zhu, W.Q. Chen, X.H. Li, L.J. Wang, L.M. Wang, Y.N. Liu, J.M. Liu, M. Zhang, J.L. 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Supplementing Glucose Intake Reverses the Inflammation Induced by a High-Fat Diet by Increasing the Expression of Siglec-E Ligands on Erythrocytes.