Early administration of nirmatrelvir/ritonavir leads to faster negative SARS-CoV-2 nasal swabs than monoclonal antibodies in COVID 19 patients at high-risk for severe disease.
In: Virology journal, Jg. 21 (2024-03-20), Heft 1, S. 68
Online
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Zugriff:
Purpose: Besides the well-established efficacy in preventing severe COVID-19, the impact of early treatments, namely antivirals and monoclonal antibodies (mAbs), on the time length to negativization of SARS-CoV-2 nasal swabs is still unclear. The aim of this study was to compare the efficacy of different early treatments in reducing the SARS-CoV-2 viral shedding, identifying a single drug that might potentially lead to a more rapid negativization of SARS-CoV-2 nasal swab.
Methods: This was a single-centre, retrospective, observational study conducted at Ospedale Luigi Sacco in Milan. Data of high-risk COVID-19 patients who received early treatments between 23 December 2021 and March 2023 were extracted. The comparison across treatments was conducted using the Kruskall-Wallis test for continuous variables. Dunn's test with Bonferroni adjustment was performed for post-hoc comparisons of days to negativization. Secondly, a negative binomial regression adjusted for age, sex, number of comorbidities, immunosuppression, and SARS-CoV-2 vaccination status was implemented.
Results: Data from 428 patients receiving early treatments were collected. The majority were treated with Nirmatrelvir/Ritonavir and were affected by SARS-CoV-2 Omicron infection with BA.2 sublineage. The median length time to SARS-CoV-2 nasal swab negativization was 9 days [IQR 7-13 days]. We found that Nirmatrelvir/Ritonavir determined a significant decrease of the length time to SARS-CoV-2 nasal swab negativization compared to mAbs (p = 0.003), but not compared to Remdesivir (p = 0.147) and Molnupiravir (p = 0.156).
Conclusion: Our findings highlight the importance of promptly treating high-risk COVID-19 patients with Nirmatrelvir/Ritonavir, as it also contributes to achieving a faster time to negative SARS-CoV-2 nasal swabs.
(© 2024. The Author(s).)
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Early administration of nirmatrelvir/ritonavir leads to faster negative SARS-CoV-2 nasal swabs than monoclonal antibodies in COVID 19 patients at high-risk for severe disease.
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Autor/in / Beteiligte Person: | Colaneri, M ; Scaglione, G ; Fassio, F ; Galli, L ; Lai, A ; Bergna, A ; Gabrieli, A ; Tarkowski, M ; Ventura, CD ; Colombo, V ; Cordier, L ; Bernasconi, D ; Corbellino, M ; Dedivitiis, G ; Borghetti, S ; Visigalli, D ; Sollima, S ; Casalini, G ; Rizzardini, G ; Gori, A ; Antinori, S ; Riva, A ; Schiavini, M |
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Zeitschrift: | Virology journal, Jg. 21 (2024-03-20), Heft 1, S. 68 |
Veröffentlichung: | [London] : BioMed Central, 2004-, 2024 |
Medientyp: | academicJournal |
ISSN: | 1743-422X (electronic) |
DOI: | 10.1186/s12985-024-02333-x |
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