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Background: Systemic inflammation contributes to cardiovascular risk and chronic obstructive pulmonary disease (COPD) pathophysiology. Associations between systemic inflammation and exposure to ambient fine particulate matter (PM ≤ 2.5 μm diameter; PM 2.5 ), and black carbon (BC), a PM 2.5 component attributable to traffic and other sources of combustion, infiltrating indoors are not well described.

Methods: Between 2012 and 2017, COPD patients completed in-home air sampling over one-week intervals, up to four times (seasonally), followed by measurement of plasma biomarkers of systemic inflammation, C-reactive protein (CRP) and interleukin-6 (IL-6), and endothelial activation, soluble vascular adhesion molecule-1 (sVCAM-1). Ambient PM 2.5 , BC and sulfur were measured at a central site. The ratio of indoor/ambient sulfur in PM 2.5 , a surrogate for fine particle infiltration, was used to estimate indoor BC and PM 2.5 of ambient origin. Linear mixed effects regression with a random intercept for each participant was used to assess associations between indoor and indoor of ambient origin PM 2.5 and BC with each biomarker.

Results: 144 participants resulting in 482 observations were included in the analysis. There were significant positive associations between indoor BC and indoor BC of ambient origin with CRP [%-increase per interquartile range (IQR);95 % CI (13.2 %;5.2-21.8 and 11.4 %;1.7-22.1, respectively)]. Associations with indoor PM 2.5 and indoor PM 2.5 of ambient origin were weaker. There were no associations with IL-6 or sVCAM-1.

Conclusions: In homes of patients with COPD without major sources of combustion, indoor BC is mainly attributable to the infiltration of ambient sources of combustion indoors. Indoor BC of ambient origin is associated with increases in systemic inflammation in patients with COPD, even when staying indoors.

Competing Interests: Declaration of competing interest None.

(Published by Elsevier B.V.)

Titel:	Indoor and ambient black carbon and fine particulate matter associations with blood biomarkers in COPD patients.
Autor/in / Beteiligte Person:	Zhang, CL ; Maccarone, JR ; Grady, ST ; Collins, CM ; Moy, ML ; Hart, JE ; Kang, CM ; Coull, BA ; Schwartz, JD ; Koutrakis, P ; Garshick, E
Zeitschrift:	The Science of the total environment, Jg. 927 (2024-06-01), S. 171897
Veröffentlichung:	Amsterdam, Elsevier., 2024
Medientyp:	academicJournal
ISSN:	1879-1026 (electronic)
DOI:	10.1016/j.scitotenv.2024.171897
Schlagwort:	Humans Male Female Aged Middle Aged Environmental Exposure statistics & numerical data Interleukin-6 blood C-Reactive Protein analysis Inflammation blood Pulmonary Disease, Chronic Obstructive blood Particulate Matter analysis Biomarkers blood Soot analysis Soot adverse effects Air Pollution, Indoor analysis Air Pollution, Indoor statistics & numerical data Air Pollution, Indoor adverse effects Air Pollutants analysis Air Pollutants adverse effects
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Sci Total Environ] 2024 Jun 01; Vol. 927, pp. 171897. <i>Date of Electronic Publication: </i>2024 Mar 22. MeSH Terms: Pulmonary Disease, Chronic Obstructive* / blood ; Particulate Matter* / analysis ; Biomarkers* / blood ; Soot* / analysis ; Soot* / adverse effects ; Air Pollution, Indoor* / analysis ; Air Pollution, Indoor* / statistics & numerical data ; Air Pollution, Indoor* / adverse effects ; Air Pollutants* / analysis ; Air Pollutants* / adverse effects ; Humans ; Male ; Female ; Aged ; Middle Aged ; Environmental Exposure / statistics & numerical data ; Interleukin-6 / blood ; C-Reactive Protein / analysis ; Inflammation / blood References: J Occup Environ Med. 2009 Sep;51(9):1088-98. (PMID: 19701101) ; Am J Respir Crit Care Med. 2000 Sep;162(3 Pt 1):981-8. (PMID: 10988117) ; Environ Res. 2022 Jun;209:112802. (PMID: 35101396) ; J Environ Monit. 2008 Sep;10(9):1041-51. (PMID: 18728896) ; J Air Waste Manag Assoc. 2010 Nov;60(11):1327-34. (PMID: 21141426) ; PLoS One. 2012;7(5):e37483. (PMID: 22624038) ; Environ Health Perspect. 2017 Oct 10;125(10):106002. (PMID: 29017987) ; Circulation. 2010 Jun 1;121(21):2331-78. (PMID: 20458016) ; Eur J Appl Physiol. 2011 Jul;111(7):1351-9. (PMID: 21153418) ; J Air Waste Manag Assoc. 2014 Jun;64(6):620-60. (PMID: 25039199) ; J Expo Sci Environ Epidemiol. 2012 Mar-Apr;22(2):161-72. (PMID: 22086209) ; Inhal Toxicol. 2004 Aug;16(9):607-13. (PMID: 16036753) ; Environ Health. 2007 Feb 01;6:3. (PMID: 17270049) ; Rev Environ Health. 2012;27(2-3):133-49. (PMID: 23023922) ; Clin Chest Med. 2014 Mar;35(1):71-86. (PMID: 24507838) ; Environ Health Perspect. 2005 Nov;113(11):1536-41. (PMID: 16263508) ; Environ Health Perspect. 2011 Apr;119(4):481-6. (PMID: 21349799) ; Eur Respir J. 2009 May;33(5):1165-85. (PMID: 19407051) ; Arterioscler Thromb Vasc Biol. 1997 Nov;17(11):2568-75. (PMID: 9409229) ; Epidemiology. 2015 May;26(3):310-20. (PMID: 25710246) ; COPD. 2016;13(1):82-92. (PMID: 26451913) ; Int J Chron Obstruct Pulmon Dis. 2018 Jan 12;13:299-307. (PMID: 29391787) ; Int J Epidemiol. 2006 Oct;35(5):1347-54. (PMID: 16844771) ; Part Fibre Toxicol. 2009 Sep 26;6:25. (PMID: 19781092) ; Circulation. 2000 Apr 18;101(15):1767-72. (PMID: 10769275) ; Am J Respir Crit Care Med. 2014 Apr 15;189(8):983-93. (PMID: 24735032) ; Respir Med. 1998 Apr;92(4):664-7. (PMID: 9659534) ; Environ Health Perspect. 2008 Jul;116(7):898-906. (PMID: 18629312) ; Environ Res. 2018 Aug;165:358-364. (PMID: 29783085) ; J Clin Invest. 2003 Jun;111(12):1805-12. (PMID: 12813013) ; J Expo Sci Environ Epidemiol. 2018 Mar;28(2):125-130. (PMID: 29064481) ; Biochim Biophys Acta Mol Basis Dis. 2021 Sep 1;1867(9):166170. (PMID: 34000374) ; Environ Health Perspect. 2009 Mar;117(3):373-8. (PMID: 19337511) ; Am J Respir Crit Care Med. 1999 Jan;159(1):179-87. (PMID: 9872837) ; Circulation. 2005 Jun 7;111(22):2913-20. (PMID: 15927967) ; Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):1793-1800. (PMID: 28751572) ; Lancet. 2018 Nov 10;392(10159):1923-1994. (PMID: 30496105) ; Crit Rev Toxicol. 2016 Feb;46(2):97-137. (PMID: 26635181) ; Environ Int. 2014 Dec;73:372-81. (PMID: 25233101) ; J Expo Sci Environ Epidemiol. 2023 May;33(3):1-7. (PMID: 35079108) ; Environ Sci Technol. 2014 Oct 21;48(20):12150-6. (PMID: 25252224) ; Sci Total Environ. 2023 Nov 1;897:165352. (PMID: 37419349) ; Environ Pollut. 2018 Dec;243(Pt B):978-987. (PMID: 30248605) ; Environ Health Perspect. 2011 Dec;119(12):1691-9. (PMID: 21810552) ; Environ Sci Technol. 2002 Dec 15;36(24):5305-14. (PMID: 12521154) ; Environ Health Perspect. 2011 Jul;119(7):997-1002. (PMID: 21447452) Grant Information: P30 ES000002 United States ES NIEHS NIH HHS; R01 ES019853 United States ES NIEHS NIH HHS; R21 ES029637 United States ES NIEHS NIH HHS Contributed Indexing: Keywords: Biomarkers; Black carbon; COPD; Particulate matter Substance Nomenclature: 0 (Particulate Matter) ; 0 (Biomarkers) ; 0 (Soot) ; 0 (Air Pollutants) ; 0 (Interleukin-6) ; 9007-41-4 (C-Reactive Protein) Entry Date(s): Date Created: 20240324 Date Completed: 20240424 Latest Revision: 20240515 Update Code: 20240515 PubMed Central ID: PMC11090036

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Indoor and ambient black carbon and fine particulate matter associations with blood biomarkers in COPD patients.