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Part of human long noncoding RNAs (lncRNAs) has been elucidated to play an essential role in the carcinogenesis and progression of hepatocellular carcinoma (HCC), a type of malignant tumor with poor outcomes. Tumor-derived exosomes harboring lncRNAs have also been implicated as crucial mediators to orchestrate biological functions among neighbor tumor cells. The recruitment of tumor-associated macrophages (TAMs) exerting M2-like phenotype usually indicates the poor prognosis. Yet, the precise involvement of tumor-derived lncRNAs in cross-talk with environmental macrophages has not been fully identified. In this study, we reported the aberrantly overexpressed HCC upregulated EZH2-associated lncRNA (HEIH) in tumor tissues and cell lines was positively correlated with poor prognosis, as well as enriched exosomal HEIH levels in blood plasma and cell supernatants. Besides, HCC cell-derived exosomes transported HEIH into macrophages for triggering macrophage M2 polarization, thereby in turn promoting the proliferation, migration, and invasion of HCC cells. Mechanistically, HEIH acted as a miRNA sponge for miR-98-5p to up-regulate STAT3, which was then further verified in the tumor xenograft models. Collectively, our study provides the evidence for recognizing tumor-derived exosomal lncRNA HEIH as a novel regulatory function through targeting miR-98-5p/STAT3 axis in environmental macrophages, which may shed light on the complicated tumor microenvironment among tumor and immune cells for HCC treatment.

Titel:	Exosomal lncRNA HEIH, an essential communicator for hepatocellular carcinoma cells and macrophage M2 polarization through the miR-98-5p/STAT3 axis.
Autor/in / Beteiligte Person:	Ai, JH ; Wen, YZ ; Dai, SJ ; Zhang, LD ; Huang, ZJ ; Shi, J
Link:	Full Text Finder (Volltext)
Zeitschrift:	Journal of biochemical and molecular toxicology, Jg. 38 (2024-04-01), Heft 4, S. e23686
Veröffentlichung:	New York, NY : Wiley, c1998-, 2024
Medientyp:	academicJournal
ISSN:	1099-0461 (electronic)
DOI:	10.1002/jbt.23686
Schlagwort:	Humans Cell Line, Tumor Macrophages metabolism Cell Proliferation genetics Gene Expression Regulation, Neoplastic Tumor Microenvironment STAT3 Transcription Factor genetics STAT3 Transcription Factor metabolism Carcinoma, Hepatocellular metabolism MicroRNAs genetics MicroRNAs metabolism RNA, Long Noncoding genetics RNA, Long Noncoding metabolism Liver Neoplasms metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [J Biochem Mol Toxicol] 2024 Apr; Vol. 38 (4), pp. e23686. MeSH Terms: Carcinoma, Hepatocellular* / metabolism ; MicroRNAs* / genetics ; MicroRNAs* / metabolism ; RNA, Long Noncoding* / genetics ; RNA, Long Noncoding* / metabolism ; Liver Neoplasms* / metabolism ; Humans ; Cell Line, Tumor ; Macrophages / metabolism ; Cell Proliferation / genetics ; Gene Expression Regulation, Neoplastic ; Tumor Microenvironment ; STAT3 Transcription Factor / genetics ; STAT3 Transcription Factor / metabolism References: F. Bray, J. Ferlay, I. Soerjomataram, R. L. Siegel, L. A. Torre, A. Jemal, CA Cancer J. Clin. 2018, 68(6), 394. ; M. M. M. Abouzied, H. M. Eltahir, M. A. Abdel Aziz, N. S. Ahmed, A. A. Abd El‐Ghany, E. A. Abd El‐Aziz, H. O. Abd El‐Aziz, Tumor Biol. 2015, 36(3), 1763. ; A. Forner, J. M. Llovet, J. Bruix, The Lancet 2012, 379(9822), 1245. ; N. Portolani, A. Coniglio, S. Ghidoni, M. 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Grant Information: 81660487 National Natural Science Foundation of China Contributed Indexing: Keywords: STAT3; hepatocellular carcinoma; lncRNA HEIH; macrophage M2 polarization; miR‐98‐5p Substance Nomenclature: 0 (MicroRNAs) ; 0 (RNA, Long Noncoding) ; 0 (STAT3 protein, human) ; 0 (STAT3 Transcription Factor) ; 0 (MIRN98 microRNA, human) Entry Date(s): Date Created: 20240329 Date Completed: 20240401 Latest Revision: 20240405 Update Code: 20240406

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Exosomal lncRNA HEIH, an essential communicator for hepatocellular carcinoma cells and macrophage M2 polarization through the miR-98-5p/STAT3 axis.