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Patients with advanced cancer are frequently burdened with a severe sensation of fatigue called cancer-related fatigue (CRF). CRF is induced at various stages and treatments, such as cachexia and chemotherapy, and reduces the overall survival of patients. Objective and quantitative assessment of CRF could contribute to the diagnosis and prediction of treatment efficacy. However, such studies have not been intensively performed, particularly regarding metabolic profiles. Here, we conducted plasma metabolomics of 15 patients with urological cancer. The patients with and without fatigue, including those with cachexia or chemotherapy-induced fatigue, were compared. Significantly lower concentrations of valine and tryptophan were observed in fatigued patients than in non-fatigued patients. In addition, significantly higher concentrations of polyamine pathway metabolites were observed in patients with fatigue and cachexia than in those without cachexia. Patients with exacerbated fatigue due to chemotherapy showed significantly decreased cysteine and methionine metabolism before chemotherapy compared with those without fatigue exacerbation. These findings suggest that plasma metabolic profiles could help improve the diagnosis and monitoring of CRF.

Titel:	Metabolomic profiling of cancer-related fatigue involved in cachexia and chemotherapy.
Autor/in / Beteiligte Person:	Okinaka, Y ; Kageyama, S ; Goto, T ; Sugimoto, M ; Tomita, A ; Aizawa, Y ; Kobayashi, K ; Wada, A ; Kawauchi, A ; Kataoka, Y
Link:	Full Text Finder (Volltext)
Zeitschrift:	Scientific reports, Jg. 14 (2024-04-09), Heft 1, S. 8329
Veröffentlichung:	London : Nature Publishing Group, copyright 2011-, 2024
Medientyp:	academicJournal
ISSN:	2045-2322 (electronic)
DOI:	10.1038/s41598-024-57747-y
Schlagwort:	Humans Metabolomics Metabolome Fatigue etiology Cachexia etiology Cachexia diagnosis Neoplasms complications Neoplasms drug therapy
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Sci Rep] 2024 Apr 09; Vol. 14 (1), pp. 8329. <i>Date of Electronic Publication: </i>2024 Apr 09. MeSH Terms: Cachexia* / etiology ; Cachexia* / diagnosis ; Neoplasms* / complications ; Neoplasms* / drug therapy ; Humans ; Metabolomics ; Metabolome ; Fatigue / etiology References: Cancer. 2005 Aug 15;104(4):788-93. (PMID: 15973668) ; Breast Cancer Res Treat. 2007 Oct;105(2):209-19. (PMID: 17203386) ; Med Sci (Basel). 2018 May 25;6(2):. (PMID: 29799508) ; Psychosom Med. 2002 Jul-Aug;64(4):604-11. (PMID: 12140350) ; Amino Acids. 2007 Aug;33(2):189-95. (PMID: 17396214) ; Cytokine. 2004 Feb 7;25(3):94-102. (PMID: 14698135) ; Clin Genitourin Cancer. 2016 Feb;14(1):63-8. (PMID: 26520429) ; Brain Res Bull. 2000 May 1;52(1):35-8. (PMID: 10779700) ; Am J Clin Nutr. 2000 Aug;72(2 Suppl):573S-8S. (PMID: 10919962) ; J Neurochem. 2005 Nov;95(4):1156-66. (PMID: 16271049) ; J Pain Symptom Manage. 1997 Feb;13(2):63-74. (PMID: 9095563) ; Clin Med (Lond). 2006 Mar-Apr;6(2):140-3. (PMID: 16688969) ; J Hum Kinet. 2020 Mar 31;72:69-78. (PMID: 32269649) ; J Clin Med. 2020 Dec 06;9(12):. (PMID: 33291298) ; Cancer. 1999 Mar 1;85(5):1186-96. (PMID: 10091805) ; Cancer. 2010 Dec 15;116(24):5740-8. (PMID: 20734399) ; PLoS One. 2014 Mar 12;9(3):e90950. (PMID: 24621600) ; Lancet Oncol. 2011 May;12(5):489-95. (PMID: 21296615) ; Lancet. 2003 Aug 23;362(9384):640-50. (PMID: 12944066) ; Cancer Med. 2021 Mar;10(5):1623-1633. (PMID: 33534943) ; Sci Rep. 2018 Aug 13;8(1):12075. (PMID: 30104641) ; Oncogene. 2019 Oct;38(41):6794-6800. (PMID: 31399646) ; PLoS One. 2019 Jul 26;14(7):e0219531. (PMID: 31348786) ; Biomedicines. 2022 Mar 08;10(3):. (PMID: 35327428) ; Exp Gerontol. 2020 Apr;132:110841. (PMID: 31954874) ; Brain Behav Immun. 2009 Aug;23(6):868-74. (PMID: 19362138) ; J Cachexia Sarcopenia Muscle. 2019 Feb;10(1):140-154. (PMID: 30680954) ; Brain Behav Immun. 2012 Jul;26(5):706-13. (PMID: 22406004) ; Oncol Nurs Forum. 2009 Mar;36(2):209-16. (PMID: 19273410) ; Int J Tryptophan Res. 2017 Jun 14;10:1178646917713491. (PMID: 28659716) ; J Chromatogr A. 2021 Aug 30;1652:462355. (PMID: 34233246) ; Cancer Res. 2019 Jul 1;79(13):3268-3280. (PMID: 31064849) ; Med Clin North Am. 2017 Nov;101(6):1085-1097. (PMID: 28992856) ; Int J Obes (Lond). 2020 Jun;44(6):1387-1396. (PMID: 32127643) ; Cancer. 2012 Dec 1;118(23):6005-11. (PMID: 22736424) ; Chin J Physiol. 2011 Apr 30;54(2):71-8. (PMID: 21789887) ; Am J Clin Nutr. 2016 Sep;104(3):776-89. (PMID: 27510537) ; Sci Rep. 2018 Jul 3;8(1):10056. (PMID: 29968805) ; J Clin Biochem Nutr. 2014 Mar;54(2):67-74. (PMID: 24688213) ; Sci Rep. 2016 Oct 11;6:34990. (PMID: 27725700) ; J Exerc Nutrition Biochem. 2013 Dec;17(4):169-80. (PMID: 25566428) ; J Natl Cancer Inst. 2013 Oct 2;105(19):1432-40. (PMID: 24047960) ; Sci Rep. 2021 Mar 12;11(1):5847. (PMID: 33712647) ; Breast. 2021 Apr;56:103-109. (PMID: 33668004) ; Free Radic Res. 2018 Jul;52(7):751-762. (PMID: 29742938) ; Biol Res Nurs. 2021 Jan;23(1):42-49. (PMID: 32696652) ; Nature. 2020 Dec;588(7836):135-140. (PMID: 33177712) ; Oncologist. 2000;5(5):353-60. (PMID: 11040270) ; J Pain Symptom Manage. 2012 Feb;43(2):226-35. (PMID: 21839608) ; Ann Neurol. 2019 Aug;86(2):251-263. (PMID: 31155745) ; J Pain Symptom Manage. 2002 Dec;24(6):547-61. (PMID: 12551804) ; J Pain Symptom Manage. 2000 Jan;19(1):5-14. (PMID: 10687321) ; PLoS One. 2015 Mar 20;10(3):e0120106. (PMID: 25793974) ; Support Care Cancer. 2013 Apr;21(4):1053-60. (PMID: 23052924) ; J Neural Transm (Vienna). 2007;114(5):555-61. (PMID: 17160370) ; Int J Radiat Oncol Biol Phys. 2004 May 1;59(1):160-7. (PMID: 15093912) ; J Clin Oncol. 2011 Sep 10;29(26):3517-22. (PMID: 21825266) ; Brain Behav Immun. 2012 Mar;26(3):394-400. (PMID: 21988771) ; Acta Physiol Scand. 1997 Jan;159(1):41-9. (PMID: 9124069) ; J Natl Compr Canc Netw. 2015 Aug;13(8):1012-39. (PMID: 26285247) ; Cancer Res. 2008 Dec 1;68(23):9735-45. (PMID: 19047152) ; Nutrition. 2009 May;25(5):597-607. (PMID: 19216057) ; Oncologist. 2007;12 Suppl 1:4-10. (PMID: 17573451) ; Curr Bioinform. 2012 Mar;7(1):96-108. (PMID: 22438836) Entry Date(s): Date Created: 20240409 Date Completed: 20240411 Latest Revision: 20240425 Update Code: 20240425 PubMed Central ID: PMC11004174

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Metabolomic profiling of cancer-related fatigue involved in cachexia and chemotherapy.