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Malaria, one of the major infectious diseases in the world, is caused by the Plasmodium parasite. Plasmodium antigens could modulate the inflammatory response by binding to macrophage membrane receptors. As an export protein on the infected erythrocyte membrane, Plasmodium surface-related antigen (SRA) participates in the erythrocyte invasion and regulates the immune response of the host. This study found that the F2 segment of P. yoelii SRA activated downstream MAPK and NF-κB signaling pathways by binding to CD68 on the surface of the macrophage membrane and regulating the inflammatory response. The anti-PySRA-F2 antibody can protect mice against P. yoelii , and the pro-inflammatory responses such as IL-1β, TNF-α, and IL-6 after infection with P. yoelii are attenuated. These findings will be helpful for understanding the involvement of the pathogenic mechanism of malaria with the exported protein SRA.

Competing Interests: The authors declare no conflict of interest.

Titel:	Plasmodium yoelii surface-related antigen (PySRA) modulates the host pro-inflammatory responses via binding to CD68 on macrophage membrane.
Autor/in / Beteiligte Person:	Feng, X ; J-L, Yu ; Y-F, Sun ; C-Y, Du ; Shen, Y ; Zhang, L ; W-Z, Kong ; Han, S ; Cheng, Y
Zeitschrift:	Infection and immunity, Jg. 92 (2024-05-07), Heft 5, S. e0011324
Veröffentlichung:	Washington, DC : American Society For Microbiology ; <i>Original Publication</i>: [Bethesda, Md.] American Society for Microbiology., 2024
Medientyp:	academicJournal
ISSN:	1098-5522 (electronic)
DOI:	10.1128/iai.00113-24
Schlagwort:	Animals Female Humans Mice Antigens, Differentiation, Myelomonocytic metabolism Antigens, Differentiation, Myelomonocytic immunology Antigens, Surface immunology Antigens, Surface metabolism Cell Membrane metabolism Cell Membrane immunology Inflammation immunology Inflammation metabolism NF-kappa B metabolism NF-kappa B immunology Protein Binding Signal Transduction Antigens, CD metabolism Antigens, CD immunology Antigens, Protozoan immunology Antigens, Protozoan metabolism Macrophages immunology Macrophages metabolism Macrophages parasitology Malaria immunology Malaria parasitology Plasmodium yoelii immunology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Infect Immun] 2024 May 07; Vol. 92 (5), pp. e0011324. <i>Date of Electronic Publication: </i>2024 Apr 16. MeSH Terms: Antigens, CD* / metabolism ; Antigens, CD* / immunology ; Antigens, Protozoan* / immunology ; Antigens, Protozoan* / metabolism ; Macrophages* / immunology ; Macrophages* / metabolism ; Macrophages* / parasitology ; Malaria* / immunology ; Malaria* / parasitology ; Plasmodium yoelii* / immunology ; Animals ; Female ; Humans ; Mice ; Antigens, Differentiation, Myelomonocytic / metabolism ; Antigens, Differentiation, Myelomonocytic / immunology ; Antigens, Surface / immunology ; Antigens, Surface / metabolism ; Cell Membrane / metabolism ; Cell Membrane / immunology ; Inflammation / immunology ; Inflammation / metabolism ; NF-kappa B / metabolism ; NF-kappa B / immunology ; Protein Binding ; Signal Transduction References: Front Immunol. 2018 Dec 19;9:3006. (PMID: 30619355) ; J Infect Dis. 2018 Jul 24;218(5):778-790. (PMID: 29912472) ; Front Immunol. 2021 Aug 13;12:678457. (PMID: 34489932) ; Trends Parasitol. 2005 Feb;21(2):75-80. (PMID: 15664530) ; Front Cell Infect Microbiol. 2017 Jul 20;7:324. (PMID: 28775960) ; Nature. 2002 Feb 7;415(6872):673-9. (PMID: 11832955) ; Malar J. 2006 Oct 10;5:85. (PMID: 17029647) ; Pathogens. 2022 May 07;11(5):. (PMID: 35631071) ; J Infect Dis. 2002 May 15;185(10):1538-41. (PMID: 11992295) ; Annu Rev Pathol. 2020 Jan 24;15:315-343. (PMID: 31648610) ; Trends Parasitol. 2013 Jan;29(1):26-34. (PMID: 23142189) ; Front Genet. 2021 Aug 05;12:688606. (PMID: 34421996) ; J Immunol. 2006 Oct 15;177(8):5736-45. (PMID: 17015763) ; Nat Rev Immunol. 2014 Nov;14(11):744-57. (PMID: 25324127) ; Front Cell Dev Biol. 2021 Dec 06;9:764109. (PMID: 34938733) ; Nat Rev Immunol. 2005 Sep;5(9):722-35. (PMID: 16138104) ; Mediterr J Hematol Infect Dis. 2012;4(1):e2012061. (PMID: 23170190) ; Trends Parasitol. 2020 May;36(5):435-446. (PMID: 32298631) ; J Immunol Res. 2021 Nov 8;2021:7785180. (PMID: 34790829) ; J Biol Chem. 1993 May 5;268(13):9661-6. (PMID: 8486654) ; Oncogene. 2006 Oct 30;25(51):6680-4. (PMID: 17072321) ; Cell Microbiol. 2012 Mar;14(3):343-55. (PMID: 22188297) ; Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):E10568-E10577. (PMID: 29162686) ; Nat Med. 2013 Feb;19(2):156-67. (PMID: 23389616) ; Am J Hematol. 2011 Feb;86(2):155-62. (PMID: 21264897) ; Int J Parasitol. 2004 Dec;34(13-14):1501-16. (PMID: 15582527) ; Curr Top Microbiol Immunol. 2005;297:25-70. (PMID: 16265902) ; Travel Med Infect Dis. 2008 Jan-Mar;6(1-2):67-81. (PMID: 18342278) ; Infect Dis Poverty. 2017 Apr 4;6(1):44. (PMID: 28372588) ; Nat Rev Immunol. 2004 Mar;4(3):169-80. (PMID: 15039754) ; J Immunol. 2004 Jan 1;172(1):475-82. (PMID: 14688357) ; Trends Parasitol. 2009 May;25(5):220-7. (PMID: 19349210) ; Cell. 2014 Jun 5;157(6):1262-1278. (PMID: 24906146) ; Science. 2012 Aug 17;337(6096):816-21. (PMID: 22745249) ; Biochem Soc Trans. 2022 Jun 30;50(3):1069-1079. (PMID: 35621119) ; Blood. 2011 Jan 13;117(2):381-92. (PMID: 20852127) ; Clin Infect Dis. 1993 Mar;16(3):361-6. (PMID: 8452947) ; J Exp Med. 2015 Aug 24;212(9):1391-403. (PMID: 26216124) Grant Information: BK20231494 JST \| Natural Science Foundation of Jiangsu Province (Jiangsu Natural Science Foundation); 2023M731343 China Postdoctoral Foundation Project \| Postdoctoral Research Foundation of China (China Postdoctoral Research Foundation) Contributed Indexing: Keywords: CD68; Plasmodium yoelii; inflammatory response; macrophage; surface-related antigen Substance Nomenclature: 0 (Antigens, CD) ; 0 (Antigens, Differentiation, Myelomonocytic) ; 0 (Antigens, Protozoan) ; 0 (Antigens, Surface) ; 0 (NF-kappa B) Entry Date(s): Date Created: 20240416 Date Completed: 20240507 Latest Revision: 20240530 Update Code: 20240530 PubMed Central ID: PMC11075460

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Plasmodium yoelii surface-related antigen (PySRA) modulates the host pro-inflammatory responses via binding to CD68 on macrophage membrane.