"The least significant change on bone mineral density scan increased in patients with higher degrees of obesity".
In: Aging clinical and experimental research, Jg. 36 (2024-04-23), Heft 1, S. 98
Online
academicJournal
Zugriff:
Background: The least significant change (LSC) threshold of 0.03 g/cm² is used to interpret bone mineral density (BMD) scans in the general population. Our working hypothesis was that the current LSC threshold would not be applicable in obese populations.
Aims: The aim of this study was to calculate the LSC in an obese population.
Methods: We performed an interventional study among 120 obesity patients, in whom two measurements of BMD were performed at 3 sites. Pairs of measures were used to calculate the LSC, using the Bland and Altman method.
Results: We calculated that the LSC was 0.046 g/cm² at the lumbar spine, 0.069 g/cm² at the femoral neck, and 0.06 g/cm² at the total hip. We also calculated the LSC for each class of obesity and observed an increase in LSC with increasing body mass index (BMI). We calculated a LSC of 0.05 g/cm² in patients with class 2 or class 3 obesity, whereas the LSC in patients with class 1 obesity is similar to the threshold used in the general population.
Discussion: In obese population, like BMD, LSC is higher than the threshold value of the general population, and increases with increasing BMI.
Conclusion: LSC of 0.05 g/cm² could be used in clinical practice in patients with class 2 or 3 obesity. These findings should help to improve the interpretation of BMD scans in these patients and optimize their management.
Trial Registration Number: Comité de Protection des Personnes Ile-de France VII, France.
(© 2024. The Author(s).)
Titel: |
"The least significant change on bone mineral density scan increased in patients with higher degrees of obesity".
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Autor/in / Beteiligte Person: | Dorilleau, C ; Kanagaratnam, L ; Charlot, I ; Hittinger, A ; Bertin, E ; Salmon, JH ; Geoffroy, M |
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Zeitschrift: | Aging clinical and experimental research, Jg. 36 (2024-04-23), Heft 1, S. 98 |
Veröffentlichung: | <2013-> : Berlin : Springer ; <i>Original Publication</i>: Milano, Italy : Editrice Kurtis, c2002-, 2024 |
Medientyp: | academicJournal |
ISSN: | 1720-8319 (electronic) |
DOI: | 10.1007/s40520-024-02736-4 |
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