| Sonstiges: |
- Nachgewiesen in: MEDLINE
- Sprachen: English
- Publication Type: Journal Article; Review
- Language: English
- [Curr Opin Support Palliat Care] 2024 Jun 01; Vol. 18 (2), pp. 78-85. <i>Date of Electronic Publication: </i>2024 Apr 23.
- MeSH Terms: Mucositis* ; Gastrointestinal Microbiome* / physiology ; Inflammation* ; Humans ; Neoplasms ; Antineoplastic Agents / adverse effects ; Intestinal Mucosa ; Biomarkers
- References: Akbarali HI, Muchhala KH, Jessup DK, Cheatham S. Chemotherapy induced gastrointestinal toxicities. Adv Cancer Res 2022; 155:131–166. ; Sonis ST. The pathobiology of mucositis. Nat Rev Cancer 2004; 4: 277–284. ; Blijlevens NMA, Donnelly JP, De Pauw BE. Mucosal barrier injury: biology, pathology, clinical counterparts and consequences of intensive treatment for haematological malignancy: an overview. Bone Marrow Transplant 2000; 25:1269–1278. ; Sougiannis AT, VanderVeen BN, Davis JM, et al. Understanding chemotherapy-induced intestinal mucositis and strategies to improve gut resilience. Am J Physiol-Gastr L 2021; 320:G712–G719. ; Sender R, Milo R. The distribution of cellular turnover in the human body. Nat Med 2021; 27:45–48. ; Patankar JV, Becker C. Cell death in the gut epithelium and implications for chronic inflammation. Nat Rev Gastroenterol Hepatol 2020; 17:543–556. ; Delgado ME, Grabinger T, Brunner T. Cell death at the intestinal epithelial front line. FEBS J 2016; 283:2701–2719. ; Dahlgren D, Sjoblom M, Hellstrom PM, Lennernas H. Chemotherapeutics-induced intestinal mucositis: pathophysiology and potential treatment strategies. Front Pharmacol 2021; 12:681417. ; Sprenkeler EGG, Zandstra J, van Kleef ND, et al. S100A8/A9 is a marker for the release of neutrophil extracellular traps and induces neutrophil activation. Cells 2022; 11:236. ; Sprenkeler EGG, Tool ATJ, Henriet SSV, et al. Formation of neutrophil extracellular traps requires actin cytoskeleton rearrangements. Blood 2022; 139:3166–3180. ; Swanson KV, Deng M, Ting JP. The NLRP3 inflammasome: molecular activation and regulation to therapeutics. Nat Rev Immunol 2019; 19:477–489. ; Privitera G, Rana N, Armuzzi A, Pizarro TT. The gasdermin protein family: emerging roles in gastrointestinal health and disease. Nat Rev Gastroenterol Hepatol 2023; 20:366–387. ; Wardill HR, de Mooij CEM, Ferreira ARD, et al. Translational model of melphalan-induced gut toxicity reveals drug–host–microbe interactions that drive tissue injury and fever. Cancer Chemother Pharmacol 2021; 88:173–188. ; Stansborough RL, Al-Dasooqi N, Bateman EH, et al. Radiotherapy-induced gut toxicity: involvement of matrix met alloproteinases and the intestinal microvasculature. Int J Radiat Biol 2016; 92:241–248. ; Bowen J, Cross C. The role of the innate immune response in oral mucositis pathogenesis. Int J Mol Sci 2023; 24:16314. ; Thaiss CA, Zmora N, Levy M, Elinav E. The microbiome and innate immunity. Nature 2016; 535:65–74. ; Im KI, Nam YS, Kim N, et al. Regulation of HMGB1 release protects chemoradiotherapy-associated mucositis. Mucosal Immunol 2019; 12:1070–1081. ; Luo X, Zhai Z, Lin Z, et al. Cyclophosphamide induced intestinal injury is alleviated by blocking the TLR9/caspase3/GSDME mediated intestinal epithelium pyroptosis. Int Immunopharmacol 2023; 119:110244. ; Dalby S, Skallerup S, Baun C, et al. PET/CT imaging detects intestinal inflammation in a mouse model of doxorubicin-induced mucositis. Front Oncol 2022; 12:1061804. ; Pan H, Jian Y, Wang F, et al. NLRP3 and gut microbiota homeostasis: progress in research. Cells 2022; 11:3758. ; Bruning EE, Coller JK, Wardill HR, Bowen JM. Site-specific contribution of Toll-like receptor 4 to intestinal homeostasis and inflammatory disease. J Cell Physiol 2021; 236:877–888. ; Wei L, Wen XS, Xian CJ. Chemotherapy-induced intestinal microbiota dysbiosis impairs mucosal homeostasis by modulating toll-like receptor signaling pathways. Int J Mol Sci 2021; 22:9474. ; Roggiani S, Mengoli M, Conti G, et al. Gut microbiota resilience and recovery after anticancer chemotherapy. Microbiome Res Rep 2023; 2:16. ; Shouval R, Waters NR, Gomes ALC, et al. Conditioning regimens are associated with distinct patterns of microbiota injury in allogeneic hematopoietic cell transplantation. Clin Cancer Res 2023; 29:165–173. ; Coutry N, Nguyen J, Soualhi S, et al. Cross talk between Paneth and tuft cells drives dysbiosis and inflammation in the gut mucosa. Proc Natl Acad Sci U S A 2023; 120:e2219431120. ; Gasaly N, de Vos P, Hermoso MA. Impact of bacterial metabolites on gut barrier function and host immunity: a focus on bacterial metabolism and its relevance for intestinal inflammation. Front Immunol 2021; 12:658354. ; Luis AS, Hansson GC. Intestinal mucus and their glycans: a habitat for thriving microbiota. Cell Host Microbe 2023; 31:1087–1100. ; Qiu J, Ma Y, Qiu J. Regulation of intestinal immunity by dietary fatty acids. Mucosal Immunol 2022; 15:846–856. ; Rashidi A, Peled JU, Ebadi M, et al. Protective effect of intestinal Blautia against neutropenic fever in allogeneic transplant recipients. Clin Infect Dis 2022; 75:1912–1920. ; Blijlevens NMA, de Mooij CEM. Mucositis and infection in hematology patients. Int J Mol Sci 2023; 24:18. ; Rashidi A, Ebadi M, Rehman TU, et al. Loss of microbiota-derived protective metabolites after neutropenic fever. Sci Rep 2022; 12:6244. ; Rashidi A, Ebadi M, Rehman TU, et al. Altered microbiota–host metabolic cross talk preceding neutropenic fever in patients with acute leukemia. Blood Adv 2021; 5:3937–3950. ; Schwabkey ZI, Wiesnoski DH, Chang CC, et al. Diet-derived metabolites and mucus link the gut microbiome to fever after cytotoxic cancer treatment. Sci Transl Med 2022; 14:eabo3445. ; Korsten S, Vromans H, Garssen J, Willemsen LEM. Butyrate protects barrier integrity and suppresses immune activation in a Caco-2/PBMC co-culture model while HDAC inhibition mimics butyrate in restoring cytokine-induced barrier disruption. Nutrients 2023; 15:2760. ; Dahlgren D, Lennernas H. Review on the effect of chemotherapy on the intestinal barrier: epithelial permeability, mucus and bacterial translocation. Biomed Pharmacother 2023; 162:114644. ; Crawford CK, Lopez Cervantes V, Quilici ML, et al. Inflammatory cytokines directly disrupt the bovine intestinal epithelial barrier. Sci Rep 2022; 12:14578. ; Shukla PK, Rao RG, Meena AS, et al. Paneth cell dysfunction in radiation injury and radio-mitigation by human alpha-defensin 5. Front Immunol 2023; 14: 1174140. ; Wang YM, Abdullah S, Luebbering N, et al. Intestinal permeability in patients undergoing stem cell transplantation correlates with systemic acute phase responses and dysbiosis. Blood Adv 2023; 7:5137–5151. ; Haroun E, Kumar PA, Saba L, et al. Intestinal barrier functions in hematologic and oncologic diseases. J Transl Med 2023; 21:233. ; Horowitz A, Chanez-Paredes SD, Haest X, Turner JR. Paracellular permeability and tight junction regulation in gut health and disease. Nat Rev Gastroenterol Hepatol 2023; 20:417–432. ; Stoma I, Littmann ER, Peled JU, et al. Compositional flux within the intestinal microbiota and risk for bloodstream infection with gram-negative bacteria. Clin Infect Dis 2021; 73:e4627–e35. ; Oami T, Abtahi S, Shimazui T, et al. Claudin-2 upregulation enhances intestinal permeability, immune activation, dysbiosis, and mortality in sepsis. Proc Natl Acad Sci U S A 2024; 121:e2217877121. ; de Mooij CEM, van der Velden W, de Haan AFJ, et al. Grading bloodstream infection risk using citrulline as a biomarker of intestinal mucositis in patients receiving intensive therapy. Bone Marrow Transplant 2022; 57:1373–1381. ; Weischendorff S, Rathe M, Petersen MJ, et al. Markers of intestinal mucositis to predict blood stream infections at the onset of fever during treatment for childhood acute leukemia. Leukemia 2024; 38:14–20. ; Wardill HR, de Mooij CEM, Ferreira ARD, et al. Supporting the gastrointestinal microenvironment during high-dose chemotherapy and stem cell transplantation by inhibiting IL-1 signaling with anakinra. Sci Rep 2022; 12:13. ; Wang J, Chang CY, Yang X, et al. p53 suppresses MHC class II presentation by intestinal epithelium to protect against radiation-induced gastrointestinal syndrome. Nat Commun 2024; 15:137. ; de Mooij CEM, van Groningen LFJ, de Haan AFJ, et al. Anakinra: efficacy in the management of fever during neutropenia and mucositis in autologous stem cell transplantation (AFFECT-2)-study protocol for a multicenter randomized double-blind placebo-controlled trial. Trials 2020; 21:16. ; Jin S, Zhu T, Deng S, et al. Dioscin ameliorates cisplatin-induced intestinal toxicity by mitigating oxidative stress and inflammation. Int Immunopharmacol 2022; 111:109111. ; Mohammed AI, Celentano A, Paolini R, et al. High molecular weight hyaluronic acid drastically reduces chemotherapy-induced mucositis and apoptotic cell death. Cell Death Dis 2023; 14:453. ; Tam JSY, Crame EE, Elz AS, et al. Effects of a novel toll-like receptor 4 antagonist IAXO-102 in a murine model of chemotherapy-induced gastrointestinal toxicity. Cancer Chemother Pharmacol 2022; 90:267–278. ; Zhao Z, Sun M, Cui X, et al. Bacillus coagulans MZY531 alleviates intestinal mucosal injury in immunosuppressive mice via modulating intestinal barrier, inflammatory response, and gut microbiota. Sci Rep 2023; 13:11181. ; Ornelas A, Dowdell AS, Lee JS, Colgan SP. Microbial metabolite regulation of epithelial cell–cell interactions and barrier function. Cells 2022; 11:944. ; Munem F, Thianhlun PCK, Anderson PH, Stringer AM. Vitamin D is a potential treatment for the management of gastrointestinal mucositis. Curr Opin Support Palliat Care 2023; 17:247–252. ; Rashidi A, Ebadi M, Rehman TU, et al. Randomized double-blind phase II trial of fecal microbiota transplantation versus placebo in allogeneic hematopoietic cell transplantation and AML. J Clin Oncol 2023; 41:5306–5319. ; Renga G, Nunzi E, Stincardini C, et al. CPX-351 exploits the gut microbiota to promote mucosal barrier function, colonization resistance and immune homeostasis. Blood 2024;. ; DeAngelo DJ, Jonas BA, Liesveld JL, et al. Phase 1/2 study of uproleselan added to chemotherapy in patients with relapsed or refractory acute myeloid leukemia. Blood 2022; 139:1135–1146. ; Dougan M, Nguyen LH, Buchbinder EI, Lazarus HM. Sargramostim for prophylactic management of gastrointestinal immune-related adverse events of immune checkpoint inhibitor therapy for cancer. Cancers (Basel) 2024; 16:501. ; Wang Z, Qu YJ, Cui M. Modulation of stem cell fate in intestinal homeostasis, injury and repair. World J Stem Cells 2023; 15:354–368. ; Wardill HR, Sonis ST, Blijlevens NMA. Using real world data to advance the provision of supportive cancer care: mucositis as a case study. Curr Opin Support Palliat Care 2022; 16:161–167. ; Sonis ST. A hypothesis for the pathogenesis of radiation-induced oral mucositis: when biological challenges exceed physiologic protective mechanisms. Implications for pharmacological prevention and treatment. Support Care Cancer 2021; 29:4939–4947. ; Hertz DL, Lustberg MB, Sonis S. Evolution of predictive risk factor analysis for chemotherapy-related toxicity. Support Care Cancer 2023; 31:601.
- Entry Date(s): Date Created: 20240423 Date Completed: 20240517 Latest Revision: 20240604
- Update Code: 20240605
|
