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The synthetic progestin, 17α-hydroxyprogesterone caproate (17-OHPC), is administered to pregnant individuals at risk for preterm birth and is likely transferred from mother to fetus. Yet, there is little information regarding the potential effects of 17-OHPC administration on behavioral and neural development in offspring. In rats, neonatal 17-OHPC exposure altered dopaminergic fiber distribution and density in the prelimbic medial prefrontal cortex (mPFC) in neonates and adolescents, respectively. Additionally, neonatal 17-OHPC exposure in male rats increased response omissions in a delay discounting task of impulsive decision-making. Because developmental 17-OHPC exposure has differential effects in males and females, investigating the effects of 17-OHPC on impulsive decision-making in female rats is necessary. The present study tested the effects of developmental 17-OHPC exposure (P1-P14) in a delay discounting task in which female rats chose between a small immediate reward and a larger delayed (0, 15 30, or 45 s) reward. 17-OHPC-exposed females made more omissions than controls. There was no effect of 17-OHPC on large reward preference nor on response time, and omissions were similar during both free- and forced-choice trials. The present study also aimed to investigate the neural mechanisms underlying omissions in 17-OHPC-exposed female rats. The dopamine transporter inhibitor, methylphenidate (MPH), was administered prior to delay discounting testing. MPH treatment did not reduce omissions in 17-OHPC-exposed females. If anything, MPH increased omissions in control females nearly fourfold during the longest delays. These results suggest that developmental 17-OHPC exposure increased omissions without affecting impulsivity or slowing decision-making. Furthermore, omissions may be regulated, at least in part, by dopaminergic mechanisms.

Titel:	Developmental exposure to 17-α-hydroxyprogesterone caproate disrupts decision-making in adult female rats: A potential role for a dopaminergic mechanism.
Autor/in / Beteiligte Person:	Graney, PL ; Chen, MY ; Wood, RI ; Wagner, CK
Zeitschrift:	Hormones and behavior, Jg. 163 (2024-07-01), S. 105550
Veröffentlichung:	New York, London, Academic Press., 2024
Medientyp:	academicJournal
ISSN:	1095-6867 (electronic)
DOI:	10.1016/j.yhbeh.2024.105550
Schlagwort:	Animals Female Rats Pregnancy Impulsive Behavior drug effects Rats, Sprague-Dawley Prefrontal Cortex drug effects Animals, Newborn Reward Decision Making drug effects 17 alpha-Hydroxyprogesterone Caproate Dopamine metabolism Delay Discounting drug effects
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Horm Behav] 2024 Jul; Vol. 163, pp. 105550. <i>Date of Electronic Publication: </i>2024 Apr 25. MeSH Terms: Decision Making* / drug effects ; 17 alpha-Hydroxyprogesterone Caproate* ; Dopamine* / metabolism ; Delay Discounting* / drug effects ; Animals ; Female ; Rats ; Pregnancy ; Impulsive Behavior / drug effects ; Rats, Sprague-Dawley ; Prefrontal Cortex / drug effects ; Animals, Newborn ; Reward References: J Psychopharmacol. 2017 Feb;31(2):272-283. (PMID: 28093027) ; Biol Psychiatry. 2006 Nov 15;60(10):1111-20. (PMID: 16806100) ; Psychopharmacology (Berl). 2014 Jan;231(1):191-8. (PMID: 23975034) ; Neuropsychopharmacology. 2002 Nov;27(5):699-711. (PMID: 12431845) ; Psychopharmacology (Berl). 2005 May;179(3):587-96. (PMID: 15864561) ; J Neurosci. 2011 Jun 8;31(23):8625-33. (PMID: 21653866) ; Cereb Cortex. 2016 Apr;26(4):1529-38. (PMID: 25596594) ; Pharmazie. 2009 Feb;64(2):123-5. (PMID: 19322953) ; Am J Obstet Gynecol. 2012 Nov;207(5):398.e1-8. (PMID: 22967833) ; Endocrinology. 2016 Jan;157(1):77-82. (PMID: 26556535) ; Psychopharmacology (Berl). 2011 Feb;213(4):723-33. (PMID: 20924752) ; Neurosci Biobehav Rev. 2011 Jan;35(3):537-55. (PMID: 20603146) ; Neuropsychopharmacology. 2015 Mar;40(4):1005-15. (PMID: 25328051) ; Psychopharmacology (Berl). 2006 Apr;185(3):315-26. (PMID: 16521033) ; Neuropsychopharmacology. 2014 Jun;39(7):1558-67. (PMID: 24496320) ; Neuroendocrinology. 2016;103(3-4):207-22. (PMID: 26065828) ; J Comp Neurol. 1988 Mar 1;269(1):58-72. (PMID: 3361004) ; Psychopharmacology (Berl). 2009 May;204(1):103-12. (PMID: 19132351) ; J Neurochem. 1973 Oct;21(4):877-81. (PMID: 4754863) ; N Engl J Med. 2003 Jun 12;348(24):2379-85. (PMID: 12802023) ; Early Hum Dev. 1991 Jul;26(1):61-7. (PMID: 1914989) ; J Neurosci. 2000 Feb 1;20(3):1208-15. (PMID: 10648725) ; J Neuroendocrinol. 2020 Jun;32(6):e12862. (PMID: 32485009) ; Behav Brain Res. 1996 Jan;74(1-2):189-97. (PMID: 8851929) ; Am J Obstet Gynecol. 2012 May;206(5):376-86. (PMID: 22542113) ; Physiol Behav. 2013 Feb 17;110-111:6-12. (PMID: 23266798) ; Biol Psychiatry. 2010 Nov 1;68(9):854-60. (PMID: 20691429) ; J Comp Neurol. 1993 Oct 15;336(3):331-44. (PMID: 7903321) ; Neuropharmacology. 2012 Apr;62(5-6):2068-77. (PMID: 22261384) ; Horm Behav. 2021 Sep;135:105039. (PMID: 34303952) ; Neurosci Lett. 1982 Oct 23;32(3):265-70. (PMID: 7177490) ; J Neuroendocrinol. 2021 Mar;33(3):e12962. (PMID: 33719165) ; Life Sci. 1996;58(12):231-9. (PMID: 8786705) ; Psychopharmacology (Berl). 2014 Jan;231(1):85-95. (PMID: 23963529) ; Dev Neurobiol. 2021 Sep;81(6):763-773. (PMID: 34318625) ; Brain Sci. 2020 May 14;10(5):. (PMID: 32422912) ; Brain Topogr. 2017 May;30(3):352-363. (PMID: 28108852) ; ACS Chem Neurosci. 2015 Jul 15;6(7):1055-1070. (PMID: 25747116) ; Behav Brain Res. 1994 Dec 15;65(2):221-9. (PMID: 7718155) ; J Child Adolesc Psychopharmacol. 2006 Dec;16(6):687-98. (PMID: 17201613) ; Am J Perinatol. 2020 Jan;37(2):127-136. (PMID: 31652479) ; J Child Psychol Psychiatry. 1996 Nov;37(8):971-87. (PMID: 9119944) Grant Information: R01 HD093907 United States HD NICHD NIH HHS Contributed Indexing: Keywords: 17-OHPC; Delay-discounting; Development; Methylphenidate; Omissions; Progestins Substance Nomenclature: 276F2O42F5 (17 alpha-Hydroxyprogesterone Caproate) ; VTD58H1Z2X (Dopamine) Entry Date(s): Date Created: 20240426 Date Completed: 20240615 Latest Revision: 20240618 Update Code: 20240618 PubMed Central ID: PMC11180592

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Developmental exposure to 17-α-hydroxyprogesterone caproate disrupts decision-making in adult female rats: A potential role for a dopaminergic mechanism.