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Furan is generated in a wide array of heat-treated foods through thermal degradation, leading to severe impairments in the male reproductive system. The main objective of this study was to investigate the potential of pomegranate peel extract (PGPE) in mitigating testicular dysfunctions induced by furan. Male rats were categorized into four groups: control/untreated, PGPE, furan, and PGPE + furan group. The study results revealed that furan-treated rats exhibited significantly elevated aminotransferase and phosphatase activity, and also generated increased oxidative stress, and reduced antioxidative stress protein activity. Additionally, protein content levels (ALT, AST, ALP, and ACP) and activities of steroidogenic Leydig cell hydroxysteroid dehydrogenase (3β-HSD and 17β-HSD) enzymes were significantly decreased. Significant variations in testicular parameters, apoptotic genes (Bcl-2, P53, and Caspase3), inflammatory and anti-inflammatory cytokines (IL1β, IL10), male sex hormones follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, and sperm quality were also observed. Furthermore, testicular histological abnormalities were confirmed by biochemical and molecular modifications. Notably, PGPE pre-treated furan-intoxicated animals exhibited significant improvements in most of the assessed parameters compared to furan-treated groups. In conclusion, PGPE presents essential preventive measures and a novel pharmacological potential therapy against furan-induced testicular injury.

Competing Interests: Declaration of competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Titel:	Mitigating effect of pomegranate peel extract against the furan induced testicular injury by apoptosis, steroidogenic enzymes and oxidative stress.
Autor/in / Beteiligte Person:	Ali, W ; Khatyan, U ; Sun, J ; Alasmari, A ; Alshahrani, MY ; Qazi, IH ; Wang, T ; Liu, Z ; Zou, H
Zeitschrift:	Chemosphere, Jg. 358 (2024-06-01), S. 142086
Veröffentlichung:	Oxford : Elsevier Science Ltd ; <i>Original Publication</i>: Oxford, New York, : Pergamon Press., 2024
Medientyp:	academicJournal
ISSN:	1879-1298 (electronic)
DOI:	10.1016/j.chemosphere.2024.142086
Schlagwort:	Male Animals Rats Testosterone metabolism Luteinizing Hormone 17-Hydroxysteroid Dehydrogenases metabolism Follicle Stimulating Hormone Leydig Cells drug effects Leydig Cells metabolism Antioxidants metabolism Oxidative Stress drug effects Testis drug effects Testis metabolism Testis pathology Plant Extracts pharmacology Plant Extracts chemistry Apoptosis drug effects Pomegranate chemistry Furans pharmacology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Chemosphere] 2024 Jun; Vol. 358, pp. 142086. <i>Date of Electronic Publication: </i>2024 Apr 24. MeSH Terms: Oxidative Stress* / drug effects ; Testis* / drug effects ; Testis* / metabolism ; Testis* / pathology ; Plant Extracts* / pharmacology ; Plant Extracts* / chemistry ; Apoptosis* / drug effects ; Pomegranate* / chemistry ; Furans* / pharmacology ; Male ; Animals ; Rats ; Testosterone / metabolism ; Luteinizing Hormone ; 17-Hydroxysteroid Dehydrogenases / metabolism ; Follicle Stimulating Hormone ; Leydig Cells / drug effects ; Leydig Cells / metabolism ; Antioxidants / metabolism Contributed Indexing: Keywords: Apoptosis; Furan; Inflammation; Oxidative stress; Pomegranate peel extract; Testicular injury Substance Nomenclature: 0 (furan) ; 0 (3 (or 17)-beta-hydroxysteroid dehydrogenase) Entry Date(s): Date Created: 20240426 Date Completed: 20240521 Latest Revision: 20240521 Update Code: 20240521

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Mitigating effect of pomegranate peel extract against the furan induced testicular injury by apoptosis, steroidogenic enzymes and oxidative stress.