Einzeltreffer — DigiBib

This study aimed to assess the association between the oral microbiome, age, and frailty. Data and saliva samples were obtained from male and female participants aged 35-70 years (n = 1357). Saliva samples were analysed by 16S rRNA gene sequencing and differences in microbial diversity and community compositions were examined in relation to chronological age and the frailty index (FI). Most alpha diversity measures (Richness, Shannon Diversity, Faith's Phylogenetic Diversity) showed an inverse association with frailty, whereas a positive association was observed with age and Shannon Diversity and Evenness. A further sex-stratified analysis revealed differences in measures of microbial diversity and composition. Multiple genera were detected as significantly differentially abundant with increasing frailty and age by at least two methods. With age, the relative abundance of Veillonella was reduced in both males and females, whereas increases in Corynebacterium appeared specific to males and Aggregatibacter, Fusobacterium, Neisseria, Stomatobaculum, and Porphyromonas specific to females. Beta diversity was significantly associated with multiple mental health components of the FI. This study shows age and frailty are differentially associated with measures of microbial diversity and composition, suggesting the oral microbiome may be a useful indicator of increased risk of frailty or a potential target for improving health in ageing adults.

Titel:	Oral microbial signatures associated with age and frailty in Canadian adults.
Autor/in / Beteiligte Person:	DeClercq, V ; Wright, RJ ; Nearing, JT ; Langille, MGI
Link:	Full Text Finder (Volltext)
Zeitschrift:	Scientific reports, Jg. 14 (2024-04-27), Heft 1, S. 9685
Veröffentlichung:	London : Nature Publishing Group, copyright 2011-, 2024
Medientyp:	academicJournal
ISSN:	2045-2322 (electronic)
DOI:	10.1038/s41598-024-60409-8
Schlagwort:	Humans Middle Aged Female Male Aged Adult Canada Bacteria genetics Bacteria classification Bacteria isolation & purification Aging Age Factors Frailty microbiology Microbiota RNA, Ribosomal, 16S genetics Mouth microbiology Saliva microbiology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Sci Rep] 2024 Apr 27; Vol. 14 (1), pp. 9685. <i>Date of Electronic Publication: </i>2024 Apr 27. MeSH Terms: Frailty* / microbiology ; Microbiota* ; RNA, Ribosomal, 16S* / genetics ; Mouth* / microbiology ; Saliva* / microbiology ; Humans ; Middle Aged ; Female ; Male ; Aged ; Adult ; Canada ; Bacteria / genetics ; Bacteria / classification ; Bacteria / isolation & purification ; Aging ; Age Factors References: J Gerontol A Biol Sci Med Sci. 2021 Jul 13;76(8):1362-1368. (PMID: 33437992) ; Genome Biol. 2013 Jan 14;14(1):R1. (PMID: 23316946) ; Curr Oncol Rep. 2021 Jul 16;23(9):104. (PMID: 34269912) ; J Oral Biol Craniofac Res. 2023 Sep-Oct;13(5):544-552. (PMID: 37396968) ; Nature. 2021 Nov;599(7885):458-464. (PMID: 34325466) ; Science. 2009 Dec 18;326(5960):1694-7. (PMID: 19892944) ; iScience. 2022 Dec 22;26(1):105839. (PMID: 36660475) ; Aging Clin Exp Res. 2020 Oct;32(10):2001-2011. (PMID: 31656031) ; J Frailty Aging. 2022;11(3):250-255. (PMID: 35799429) ; Nat Aging. 2022 Oct;2(10):941-955. (PMID: 36398033) ; Gastroenterology. 2021 Jan;160(2):507-523. (PMID: 33307030) ; NPJ Biofilms Microbiomes. 2023 May 1;9(1):23. (PMID: 37127667) ; Front Cell Infect Microbiol. 2021 Aug 17;11:696186. (PMID: 34485176) ; Gut. 2019 Jun;68(6):1108-1114. (PMID: 30670574) ; Nat Metab. 2021 Feb;3(2):274-286. (PMID: 33619379) ; Ann Appl Stat. 2020 Mar;14(1):94-115. (PMID: 32983313) ; Nature. 2012 Jun 13;486(7402):207-14. (PMID: 22699609) ; Gut Microbes. 2023 Dec;15(2):2278225. (PMID: 37968837) ; J Gerontol A Biol Sci Med Sci. 2021 Oct 13;76(11):1930-1938. (PMID: 34125200) ; Microbiome. 2014 May 05;2:15. (PMID: 24910773) ; Genome Med. 2016 Jan 29;8(1):8. (PMID: 26822992) ; J Am Geriatr Soc. 2016 Jun;64(6):1281-6. (PMID: 27321607) ; J Gerontol A Biol Sci Med Sci. 2017 Oct 12;72(11):1474-1482. (PMID: 28444190) ; PLoS One. 2013 Apr 22;8(4):e61217. (PMID: 23630581) ; Front Microbiol. 2017 Jun 23;8:1162. (PMID: 28690602) ; Front Microbiol. 2017 Nov 07;8:2114. (PMID: 29163406) ; Front Cell Infect Microbiol. 2021 Jul 30;11:716493. (PMID: 34395316) ; PLoS Comput Biol. 2021 Nov 16;17(11):e1009442. (PMID: 34784344) ; Gut. 2016 May;65(5):749-56. (PMID: 26719299) ; Nat Rev Neurosci. 2012 Oct;13(10):701-12. (PMID: 22968153) ; PLoS One. 2019 Jul 24;14(7):e0215262. (PMID: 31339887) ; mSystems. 2019 Feb 12;4(1):. (PMID: 30801021) ; Nat Commun. 2018 Jul 9;9(1):2655. (PMID: 29985401) ; Sci Rep. 2021 Jul 22;11(1):15009. (PMID: 34294835) ; Int J Mol Sci. 2020 Nov 25;21(23):. (PMID: 33255677) ; Science. 2021 Mar 26;371(6536):. (PMID: 33766858) ; Nat Methods. 2020 Mar;17(3):261-272. (PMID: 32015543) ; mSphere. 2018 Aug 15;3(4):. (PMID: 30111628) ; Sci Rep. 2021 Feb 25;11(1):4628. (PMID: 33633246) ; Ann Geriatr Med Res. 2021 Sep;25(3):141-149. (PMID: 34399574) ; mSphere. 2020 Sep 30;5(5):. (PMID: 32999079) ; Int J Environ Res Public Health. 2022 Oct 27;19(21):. (PMID: 36360876) ; Sci Rep. 2022 Nov 7;12(1):18894. (PMID: 36344584) ; J Gerontol A Biol Sci Med Sci. 2007 Jul;62(7):738-43. (PMID: 17634321) ; PLoS One. 2021 Dec 9;16(12):e0261032. (PMID: 34882708) ; Int J Epidemiol. 2017 Dec 1;46(6):1762-1763i. (PMID: 29025120) ; BMC Oral Health. 2021 Oct 4;21(1):490. (PMID: 34602059) ; Annu Rev Microbiol. 1985;39:175-93. (PMID: 3904599) ; Arch Gerontol Geriatr. 2020 Jul 26;91:104207. (PMID: 32781378) ; Genome Med. 2016 Apr 27;8(1):51. (PMID: 27122046) ; Comput Struct Biotechnol J. 2021 Dec 30;20:421-433. (PMID: 35035791) ; Aging (Albany NY). 2024 Feb 1;16(3):2638-2656. (PMID: 38305839) ; PeerJ. 2016 Oct 18;4:e2584. (PMID: 27781170) ; Nutrients. 2019 Dec 26;12(1):. (PMID: 31887978) ; Nutrients. 2022 Jun 12;14(12):. (PMID: 35745166) ; PLoS One. 2020 Apr 1;15(4):e0228530. (PMID: 32236095) ; Aging (Albany NY). 2020 May 7;12(9):7874-7907. (PMID: 32379704) ; Immunity. 2017 Apr 18;46(4):562-576. (PMID: 28423337) ; Sci Rep. 2021 Jan 13;11(1):929. (PMID: 33441710) ; Sci Rep. 2018 Jan 11;8(1):414. (PMID: 29323208) ; BMC Oral Health. 2019 Nov 13;19(1):246. (PMID: 31722703) ; CMAJ. 2018 Jun 11;190(23):E710-E717. (PMID: 29891475) ; BMC Geriatr. 2008 Sep 30;8:24. (PMID: 18826625) ; Clin Nutr. 2022 Jul;41(7):1491-1500. (PMID: 35667265) ; BMC Microbiol. 2019 Oct 28;19(1):236. (PMID: 31660868) ; Nutrients. 2020 Dec 07;12(12):. (PMID: 33297486) ; Front Cell Infect Microbiol. 2022 Mar 15;12:851404. (PMID: 35372105) ; Nat Biotechnol. 2019 Aug;37(8):852-857. (PMID: 31341288) ; Database (Oxford). 2010 Jul 06;2010:baq013. (PMID: 20624719) ; Exp Gerontol. 2022 Oct 1;167:111927. (PMID: 35981616) Substance Nomenclature: 0 (RNA, Ribosomal, 16S) Entry Date(s): Date Created: 20240427 Date Completed: 20240427 Latest Revision: 20240430 Update Code: 20240430 PubMed Central ID: PMC11055859

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

Oral microbial signatures associated with age and frailty in Canadian adults.