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Introduction: We explored the variations of blood biomarkers of Alzheimer's disease (AD) by chronic diseases and systemic inflammation.

Methods: We explored the association of AD blood biomarkers with chronic diseases and systemic inflammation (interleukin-6 [IL-6]), in 2366 dementia-free participants of the Swedish National Study on Aging and Care-in Kungsholmen, using quantile regression models.

Results: A greater number of co-occurring chronic diseases was associated with higher concentrations of phosphorylated-tau 181 (p-tau181), total-tau (t-tau), neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP) (p < 0.01). Anemia, kidney, cerebrovascular, and heart diseases were associated with variations in the levels of AD blood biomarkers. Participants in the highest (vs. lowest) interleukin-6 (IL-6) tertile had higher NfL concentration. Systemic inflammation amplified the associations between several chronic diseases and p-tau181, t-tau, NfL, and GFAP.

Discussion: In the community, the concentration of AD blood biomarkers varies in relation to medical conditions and systemic inflammation. Recognizing these influences is crucial for the accurate interpretation and clinical implementation of blood biomarkers.

Highlights: Participants with a complex clinical profile (i.e., multiple co-occurring diseases or specific disease combinations) display elevated levels of AD blood-biomarkers. Anemia, heart, cerebrovascular, and kidney diseases are associated with variations is the levels of AD blood biomarkers in cognitively intact older adults. Systemic inflammation amplifies the association between several chronic diseases and AD blood biomarkers.

Titel:	Blood biomarkers of Alzheimer's disease in the community: Variation by chronic diseases and inflammatory status.
Autor/in / Beteiligte Person:	Valletta, M ; Vetrano, DL ; Rizzuto, D ; Winblad, B ; Canevelli, M ; Andersson, S ; Dale, M ; Fredolini, C ; Fratiglioni, L ; Grande, G
Link:	Full Text Finder (Volltext)
Zeitschrift:	Alzheimer's & dementia : the journal of the Alzheimer's Association, Jg. 20 (2024-06-01), Heft 6, S. 4115-4125
Veröffentlichung:	2020- : Hoboken, NJ : John Wiley & Sons, Ltd. ; <i>Original Publication</i>: Orlando, FL : Elsevier, Inc., 2024
Medientyp:	academicJournal
ISSN:	1552-5279 (electronic)
DOI:	10.1002/alz.13860
Schlagwort:	Humans Female Male Aged Chronic Disease Sweden epidemiology Aged, 80 and over Glial Fibrillary Acidic Protein blood Neurofilament Proteins blood Alzheimer Disease blood Biomarkers blood Inflammation blood Interleukin-6 blood tau Proteins blood
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Alzheimers Dement] 2024 Jun; Vol. 20 (6), pp. 4115-4125. <i>Date of Electronic Publication: </i>2024 May 08. MeSH Terms: Alzheimer Disease* / blood ; Biomarkers* / blood ; Inflammation* / blood ; Interleukin-6* / blood ; tau Proteins* / blood ; Humans ; Female ; Male ; Aged ; Chronic Disease ; Sweden / epidemiology ; Aged, 80 and over ; Glial Fibrillary Acidic Protein / blood ; Neurofilament Proteins / blood References: Nat Rev Cardiol. 2018 Sep;15(9):505-522. (PMID: 30065258) ; Alzheimers Dement. 2024 Jun;20(6):4115-4125. (PMID: 38717935) ; J Neurol Neurosurg Psychiatry. 2022 Apr 27;:. (PMID: 35477892) ; Lancet. 2007 Oct 20;370(9596):1453-7. (PMID: 18064739) ; Aging Clin Exp Res. 2004 Apr;16(2):158-68. (PMID: 15195992) ; Alzheimers Dement. 2021 Aug;17(8):1353-1364. (PMID: 33580742) ; Neurology. 2019 Aug 27;93(9):e917-e926. (PMID: 31366722) ; Ann N Y Acad Sci. 2000 Jun;908:244-54. (PMID: 10911963) ; J Am Heart Assoc. 2022 Oct 18;11(20):e026460. (PMID: 36250665) ; Age Ageing. 2021 Jan 8;50(1):113-119. (PMID: 32939533) ; Nat Rev Cardiol. 2015 May;12(5):267-77. (PMID: 25583619) ; J Gerontol A Biol Sci Med Sci. 2017 Oct 01;72(10):1417-1423. (PMID: 28003375) ; Alzheimers Dement. 2022 Jun;18(6):1141-1154. (PMID: 34494715) ; J Psychiatr Res. 1975 Nov;12(3):189-98. (PMID: 1202204) ; Alzheimers Dement. 2024 Mar;20(3):1958-1965. (PMID: 38170758) ; Transl Neurodegener. 2023 Aug 18;12(1):39. (PMID: 37596644) ; Nat Med. 2022 Jul;28(7):1398-1405. (PMID: 35618838) ; Alzheimers Dement. 2023 Jan;19(1):36-43. (PMID: 35235702) ; Blood. 2004 Oct 15;104(8):2263-8. (PMID: 15238427) ; Circulation. 2010 Aug 17;122(7):690-7. (PMID: 20679552) ; Lancet Neurol. 2022 Jan;21(1):66-77. (PMID: 34838239) ; JAMA Netw Open. 2023 Jan 3;6(1):e2252387. (PMID: 36692879) ; J Gerontol A Biol Sci Med Sci. 2019 May 16;74(6):877-883. (PMID: 30124772) ; Brain. 2020 Apr 1;143(4):1220-1232. (PMID: 32206776) ; Arch Neurol. 2008 Jul;65(7):963-7. (PMID: 18625866) ; Europace. 2018 Aug 1;20(8):1252-1258. (PMID: 29016776) ; Nat Med. 2019 Dec;25(12):1822-1832. (PMID: 31806905) ; Neurology. 2023 Jul 18;101(3):e277-e288. (PMID: 37225431) ; Nat Med. 2021 Jun;27(6):1034-1042. (PMID: 34031605) ; Curr Neuropharmacol. 2021;19(7):908-924. (PMID: 33176652) ; Alzheimers Dement. 2023 Feb;19(2):671-695. (PMID: 36401868) ; Lancet Neurol. 2017 Aug;16(8):661-676. (PMID: 28721928) ; Nat Commun. 2020 Jun 26;11(1):3223. (PMID: 32591506) ; Alzheimers Dement. 2023 Dec;19(12):5672-5680. (PMID: 37392405) ; Nat Med. 2020 Mar;26(3):379-386. (PMID: 32123385) ; Alzheimers Dement. 2016 Apr;12(4):391-8. (PMID: 26607820) ; Hypertension. 2020 Jul;76(1):217-225. (PMID: 32450739) ; Neurology. 2016 May 31;86(22):2077-84. (PMID: 27164657) ; J Am Geriatr Soc. 2015 Sep;63(9):1783-90. (PMID: 26311270) ; Alzheimers Dement. 2022 Dec;18(12):2669-2686. (PMID: 35908251) ; Alzheimers Res Ther. 2022 May 11;14(1):65. (PMID: 35545792) ; Neurology. 2013 Aug 6;81(6):528-33. (PMID: 23902706) ; Eur Heart J. 2008 Sep;29(17):2125-32. (PMID: 18667399) ; Neurology. 2021 Jun 14;96(24):e2956-e2965. (PMID: 33952656) ; Aging Clin Exp Res. 2022 Feb;34(2):331-339. (PMID: 35018623) ; Alzheimers Dement. 2022 Feb;18(2):240-250. (PMID: 34310015) ; Nat Aging. 2021 Jan;1(1):114-123. (PMID: 37117993) ; Lancet Neurol. 2020 May;19(5):422-433. (PMID: 32333900) ; Lancet Healthy Longev. 2022 Jun;3(6):e428-e436. (PMID: 35711612) ; Alzheimers Dement. 2022 Jun;18(6):1128-1140. (PMID: 34569696) ; Mediators Inflamm. 2011;2011:949072. (PMID: 21772670) ; Ann Clin Transl Neurol. 2020 Jan;7(1):139-143. (PMID: 31893563) Grant Information: 2021-00178 Swedish Research Council; 2021-03324 Swedish Research Council; Swedish Ministry of Health and Social Affairs; LA2023-0113 Stiftelsen Sigurd och Elsa Goljes minne; 2021-0025 Hjärnfonden; 2021-01235 Gamla Tjänarinnor foundation; Karolinska Institutet Strategic Research Area in Epidemiology and Biostatistics (SFOEpi) Contributed Indexing: Keywords: Alzheimer's disease; blood biomarkers; chronic diseases; dementia; inflammation; population‐based study Substance Nomenclature: 0 (Biomarkers) ; 0 (Interleukin-6) ; 0 (tau Proteins) ; 0 (neurofilament protein L) ; 0 (Glial Fibrillary Acidic Protein) ; 0 (Neurofilament Proteins) Entry Date(s): Date Created: 20240508 Date Completed: 20240617 Latest Revision: 20240619 Update Code: 20240619 PubMed Central ID: PMC11180869

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Blood biomarkers of Alzheimer's disease in the community: Variation by chronic diseases and inflammatory status.