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To understand the distribution and antimicrobial resistance (AMR) of pathogens in respiratory samples in Changle District People's Hospital in Fujian Province in recent years, and provide empirical guidance for infection control and clinical treatment in the region. A retrospective analysis was conducted on 5137 isolates of pathogens from respiratory samples collected from 2019 to 2022. The AMR patterns were systematically analyzed. For research purposes, the data was accessed on October 12, 2023. A total of 3517 isolates were included in the study, including 811 (23.06%) gram-positive bacteria and 2706 (76.94%) gram-negative bacteria. The top 3 gram-positive bacteria were Staphylococcus aureus with 455 isolates (12.94%), Streptococcus pneumoniae with 99 isolates (2.81%), and Staphylococcus hemolytic with 99 isolates (2.81%). The top 3 gram-negative bacteria were Klebsiella pneumoniae with 815 isolates (23.17%), Pseudomonas aeruginosa with 589 isolates (16.75%), and Acinetobacter baumannii with 328 isolates (9.33%). The proportion of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli and K pneumoniae fluctuated between 41.9% and 70.5%, and 18.6% and 20.9%, respectively. The resistance rates of E coli, K pneumoniae, P aeruginosa, and A baumannii to carbapenems were 2.36%, 8.9%, 18.5%, and 19.6%, respectively. The prevalence of methicillin-resistant S aureus (MRSA) was 48.55%, but it decreased to 38.4% by 2022. The resistance rate of Staphylococcus haemolyticus to methicillin was 100%, and 1 case of vancomycin-resistant strain was detected. K pneumoniae, P aeruginosa, A baumannii, and S aureus are the main pathogens in respiratory samples. Although the resistance rates of some multidrug-resistant strains have decreased, ESBL-producing Enterobacteriaceae, carbapenem-resistant bacteria have still increased. Therefore, it is necessary to strengthen the monitoring of pathogen resistance, promote rational use of antibiotics, and promptly report findings.

Competing Interests: The authors have no funding and conflicts of interest to disclose.

Titel:	Monitoring of antimicrobial resistance in respiratory tract pathogens during the COVID-19 pandemic: A retrospective study.
Autor/in / Beteiligte Person:	You, T ; Shi, K
Link:	Full Text Finder (Volltext)
Zeitschrift:	Medicine, Jg. 103 (2024-05-10), Heft 19, S. e38101
Veröffentlichung:	Hagerstown, Md : Lippincott Williams & Wilkins, 2024
Medientyp:	academicJournal
ISSN:	1536-5964 (electronic)
DOI:	10.1097/MD.0000000000038101
Schlagwort:	Humans Retrospective Studies China epidemiology Drug Resistance, Bacterial Gram-Negative Bacteria drug effects Gram-Negative Bacteria isolation & purification Microbial Sensitivity Tests SARS-CoV-2 Gram-Positive Bacteria drug effects Gram-Positive Bacteria isolation & purification Respiratory Tract Infections microbiology Respiratory Tract Infections epidemiology Respiratory Tract Infections drug therapy COVID-19 epidemiology Anti-Bacterial Agents pharmacology Anti-Bacterial Agents therapeutic use
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Observational Study Language: English [Medicine (Baltimore)] 2024 May 10; Vol. 103 (19), pp. e38101. MeSH Terms: Respiratory Tract Infections* / microbiology ; Respiratory Tract Infections* / epidemiology ; Respiratory Tract Infections* / drug therapy ; COVID-19* / epidemiology ; Anti-Bacterial Agents* / pharmacology ; Anti-Bacterial Agents* / therapeutic use ; Humans ; Retrospective Studies ; China / epidemiology ; Drug Resistance, Bacterial ; Gram-Negative Bacteria / drug effects ; Gram-Negative Bacteria / isolation & purification ; Microbial Sensitivity Tests ; SARS-CoV-2 ; Gram-Positive Bacteria / drug effects ; Gram-Positive Bacteria / isolation & purification References: J Antimicrob Chemother. 1997 Jul;40(1):135-6. (PMID: 9249217) ; Antimicrob Resist Infect Control. 2018 Feb 20;7:26. (PMID: 29484173) ; Clin Microbiol Infect. 2016 Mar;22 Suppl 1:S9-14. (PMID: 27000156) ; Antimicrob Resist Infect Control. 2020 Jan 31;9(1):23. (PMID: 32005246) ; Infect Control Hosp Epidemiol. 2018 Jan;39(1):101-103. (PMID: 29249218) ; PLoS One. 2015 Oct 20;10(10):e0140754. (PMID: 26485570) ; MMWR Morb Mortal Wkly Rep. 2002 Jul 5;51(26):565-7. (PMID: 12139181) ; Clin Infect Dis. 2018 Nov 13;67(suppl_2):S128-S134. (PMID: 30423045) ; Emerg Infect Dis. 2001 Mar-Apr;7(2):327-32. (PMID: 11294734) ; Front Microbiol. 2020 Jun 30;11:1480. (PMID: 32695092) ; Indian J Med Microbiol. 2016 Oct-Dec;34(4):500-505. (PMID: 27934830) ; Swiss Med Wkly. 2021 Mar 01;151:w20454. (PMID: 33705560) ; Microb Drug Resist. 2018 Sep;24(7):1002-1005. (PMID: 29584568) ; BMC Pediatr. 2014 Apr 17;14:105. (PMID: 24742105) ; Clin Infect Dis. 1997 Jan;24 Suppl 1:S74-9. (PMID: 8994782) ; J Thorac Dis. 2014 Oct;6(10):1403-10. (PMID: 25364517) ; Microb Drug Resist. 2022 Mar;28(3):338-345. (PMID: 34870473) ; Int J Infect Dis. 2021 Feb;103:132-137. (PMID: 33212254) ; Interdiscip Perspect Infect Dis. 2014;2014:541340. (PMID: 25140175) ; Antibiotics (Basel). 2021 Jan 29;10(2):. (PMID: 33573070) ; Ann Clin Microbiol Antimicrob. 2017 Mar 29;16(1):18. (PMID: 28356109) ; PLoS One. 2020 Jan 27;15(1):e0227947. (PMID: 31986167) ; Adv Exp Med Biol. 2017;1022:19-26. (PMID: 28456930) ; J Gen Intern Med. 2017 Mar;32(3):262-268. (PMID: 27752880) ; Nat Rev Microbiol. 2015 Jan;13(1):42-51. (PMID: 25435309) ; Infect Drug Resist. 2018 Oct 10;11:1645-1658. (PMID: 30349322) ; N Engl J Med. 2013 Jan 24;368(4):299-302. (PMID: 23343059) ; Epidemiol Infect. 2013 Aug;141(8):1705-12. (PMID: 23034125) ; Int J Environ Res Public Health. 2020 Sep 23;17(19):. (PMID: 32977435) ; Nat Rev Microbiol. 2019 Jan;17(1):3. (PMID: 30467331) ; Antimicrob Resist Infect Control. 2016 May 14;5:18. (PMID: 27186369) ; Eur J Clin Microbiol Infect Dis. 2019 Dec;38(12):2275-2281. (PMID: 31478103) ; Clin Microbiol Infect. 2015 Mar;21(3):255.e1-5. (PMID: 25658549) ; Clin Infect Dis. 2000 Jan;30(1):55-60. (PMID: 10619733) Substance Nomenclature: 0 (Anti-Bacterial Agents) Entry Date(s): Date Created: 20240510 Date Completed: 20240510 Latest Revision: 20240610 Update Code: 20240611 PubMed Central ID: PMC11081541

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Monitoring of antimicrobial resistance in respiratory tract pathogens during the COVID-19 pandemic: A retrospective study.