Einzeltreffer — DigiBib

The goal of this study is to examine the association between in utero drought exposure and epigenetic age acceleration (EAA) in a global climate change hot spot. Calculations of EAA in adults using DNA methylation have been found to accurately predict chronic disease and longevity. However, fewer studies have examined EAA in children, and drought exposure in utero has not been investigated. Additionally, studies of EAA in low-income countries with diverse populations are rare. We assess EAA using epigenetic clocks and two DNAm-based pace-of-aging measurements from whole saliva samples in 104 drought-exposed children and 109 same-sex sibling controls in northern Kenya. We find a positive association between in utero drought exposure and EAA in two epigenetic clocks (Hannum's and GrimAge) and a negative association in the DNAm based telomere length (DNAmTL) clock. The combined impact of drought's multiple deleterious stressors may reduce overall life expectancy through accelerated epigenetic aging.

Titel:	Severe drought exposure in utero associates to children's epigenetic age acceleration in a global climate change hot spot.
Autor/in / Beteiligte Person:	Qiao, X ; Straight, B ; Ngo, D ; Hilton, CE ; Owuor Olungah, C ; Naugle, A ; Lalancette, C ; Needham, BL
Link:	Full Text Finder (Volltext)
Zeitschrift:	Nature communications, Jg. 15 (2024-05-16), Heft 1, S. 4140
Veröffentlichung:	[London] : Nature Pub. Group, 2024
Medientyp:	academicJournal
ISSN:	2041-1723 (electronic)
DOI:	10.1038/s41467-024-48426-7
Schlagwort:	Humans Female Kenya Male Child Pregnancy Aging genetics Saliva metabolism Child, Preschool Droughts Epigenesis, Genetic Climate Change DNA Methylation Prenatal Exposure Delayed Effects genetics Prenatal Exposure Delayed Effects metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Nat Commun] 2024 May 16; Vol. 15 (1), pp. 4140. <i>Date of Electronic Publication: </i>2024 May 16. MeSH Terms: Droughts* ; Epigenesis, Genetic* ; Climate Change* ; DNA Methylation* ; Prenatal Exposure Delayed Effects* / genetics ; Prenatal Exposure Delayed Effects* / metabolism ; Humans ; Female ; Kenya ; Male ; Child ; Pregnancy ; Aging / genetics ; Saliva / metabolism ; Child, Preschool References: Proc Natl Acad Sci U S A. 2022 Nov 15;119(46):e2208530119. (PMID: 36346848) ; Mol Cell. 2013 Jan 24;49(2):359-367. (PMID: 23177740) ; Elife. 2022 Jan 14;11:. (PMID: 35029144) ; Afr J Prim Health Care Fam Med. 2023 May 15;15(1):e1-e3. (PMID: 37265162) ; Environ Int. 2021 Oct;155:106683. (PMID: 34144479) ; PLoS One. 2022 Mar 21;17(3):e0265617. (PMID: 35312716) ; Aging (Albany NY). 2018 Jul 26;10(7):1758-1775. (PMID: 30048243) ; Genome Biol. 2013;14(10):R115. (PMID: 24138928) ; Geroscience. 2024 Feb;46(1):39-56. (PMID: 37597113) ; Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17219-17224. (PMID: 31405971) ; Epigenetics. 2022 Dec;17(13):2421-2433. (PMID: 36242778) ; Epigenetics. 2018;13(1):85-94. (PMID: 29235933) ; Nat Rev Genet. 2018 Jun;19(6):371-384. (PMID: 29643443) ; Aging (Albany NY). 2022 Dec 14;14(23):9484-9549. (PMID: 36516495) ; Clin Epigenetics. 2023 Apr 12;15(1):62. (PMID: 37046280) ; Aging (Albany NY). 2018 Apr 18;10(4):573-591. (PMID: 29676998) ; Aging (Albany NY). 2019 Nov 22;11(22):10031-10051. (PMID: 31756171) ; Environ Epigenet. 2023 Jul 15;9(1):dvad005. (PMID: 37564905) ; Clin Epigenetics. 2016 Jun 03;8:64. (PMID: 27274774) ; Ann N Y Acad Sci. 2006 May;1067:1-9. (PMID: 16803964) ; EBioMedicine. 2017 Jul;21:29-36. (PMID: 28396265) ; Epigenetics. 2022 Jun;17(6):589-611. (PMID: 34227900) ; Sci Data. 2015 Dec 08;2:150066. (PMID: 26646728) ; Ageing Res Rev. 2022 Nov;81:101743. (PMID: 36206857) ; Genes (Basel). 2023 Jan 27;14(2):. (PMID: 36833255) ; Biol Psychiatry. 2022 Feb 1;91(3):303-312. (PMID: 34756561) ; EBioMedicine. 2016 Feb 08;5:68-73. (PMID: 27077113) ; J Gerontol A Biol Sci Med Sci. 2021 May 22;76(6):1117-1123. (PMID: 33453106) ; Soc Sci Med. 2021 Aug;283:114182. (PMID: 34225037) ; Elife. 2020 May 05;9:. (PMID: 32367804) ; Diabet Med. 2022 Nov;39(11):e14925. (PMID: 36224717) ; Epigenomics. 2021 Nov;13(21):1677-1699. (PMID: 33749330) ; Aging (Albany NY). 2019 Jan 21;11(2):303-327. (PMID: 30669119) ; Dev Psychobiol. 2021 Jul;63(5):890-902. (PMID: 33423276) ; Am J Hum Biol. 2023 Jan;35(1):e23803. (PMID: 36125188) ; Dev Psychobiol. 2020 Mar;62(2):138-153. (PMID: 31724171) ; PLoS Curr. 2013 Jun 05;5:. (PMID: 23787891) ; Ageing Res Rev. 2022 Feb;74:101557. (PMID: 34990845) ; Science. 2015 Dec 4;350(6265):1193-8. (PMID: 26785477) ; Int J Obes (Lond). 2013 Aug;37(8):1036-43. (PMID: 23164700) ; Am J Hum Biol. 2007 Sep-Oct;19(5):631-42. (PMID: 17636530) ; Genome Biol. 2019 Nov 25;20(1):249. (PMID: 31767039) ; Am J Physiol Regul Integr Comp Physiol. 2005 Jan;288(1):R25-33. (PMID: 15590994) ; Front Aging. 2021 Jul 29;2:697254. (PMID: 35822029) ; Aging (Albany NY). 2019 Aug 18;11(16):5895-5923. (PMID: 31422385) ; Soc Sci Med. 2020 Sep;261:113234. (PMID: 32823214) ; Epigenomics. 2018 Jul;10(7):925-940. (PMID: 29693419) ; Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23329-23335. (PMID: 31611402) Grant Information: 1728743 NSF \| Directorate for Social, Behavioral & Economic Sciences \| Division of Behavioral and Cognitive Sciences (Behavioral & Cognitive Sciences) Entry Date(s): Date Created: 20240516 Date Completed: 20240516 Latest Revision: 20240519 Update Code: 20240519 PubMed Central ID: PMC11099019

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Severe drought exposure in utero associates to children's epigenetic age acceleration in a global climate change hot spot.