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The aim of this study was to systematically investigate structural and functional alterations in amygdala subregions using multimodal magnetic resonance imaging (MRI) in patients with tinnitus with or without affective dysfunction. Sixty patients with persistent tinnitus and 40 healthy controls (HCs) were recruited. Based on a questionnaire assessment, 26 and 34 patients were categorized into the tinnitus patients with affective dysfunction (TPAD) and tinnitus patients without affective dysfunction (TPWAD) groups, respectively. MRI-based measurements of gray matter volume, fractional anisotropy (FA), fractional amplitude of low-frequency fluctuations (fALFF), regional homogeneity (ReHo), degree centrality (DC), and functional connectivity (FC) were conducted within 14 amygdala subregions for intergroup comparisons. Associations between the MRI properties and clinical characteristics were estimated via partial correlation analyses. Compared with that of the HCs, the TPAD and TPWAD groups exhibited significant structural and functional changes, including white matter integrity (WMI), fALFF, ReHo, DC, and FC alterations, with more pronounced WMI changes in the TPAD group, predominantly within the left auxiliary basal or basomedial nucleus (AB/BM), right central nucleus, right lateral nuclei (dorsal portion), and left lateral nuclei (ventral portion containing basolateral portions). Moreover, the TPAD group exhibited decreased FC between the left AB/BM and left middle occipital gyrus and right superior frontal gyrus (SFG), left basal nucleus and right SFG, and right lateral nuclei (intermediate portion) and right SFG. In combination, these amygdalar alterations exhibited a sensitivity of 65.4% and specificity of 96.9% in predicting affective dysfunction in patients with tinnitus. Although similar structural and functional amygdala remodeling were observed in the TPAD and TPWAD groups, the changes were more pronounced in the TPAD group. These changes mainly involved alterations in functionality and white matter microstructure in various amygdala subregions; in combination, these changes could serve as an imaging-based predictor of emotional disorders in patients with tinnitus.

Titel:	Amygdala structural and functional reorganization as an indicator of affective dysfunction in patients with tinnitus.
Autor/in / Beteiligte Person:	Huang, Y ; Chen, Q ; Lv, H ; Wang, Z ; Wang, X ; Liu, C ; Zhao, P ; Yang, Z ; Gong, S
Link:	Full Text Finder (Volltext)
Zeitschrift:	Human brain mapping, Jg. 45 (2024-06-01), Heft 8, S. e26712
Veröffentlichung:	New York : Wiley ; <i>Original Publication</i>: New York : Wiley-Liss, c1993-, 2024
Medientyp:	academicJournal
ISSN:	1097-0193 (electronic)
DOI:	10.1002/hbm.26712
Schlagwort:	Humans Male Female Adult Middle Aged Gray Matter diagnostic imaging Gray Matter pathology Gray Matter physiopathology Mood Disorders diagnostic imaging Mood Disorders etiology Mood Disorders physiopathology Mood Disorders pathology Tinnitus diagnostic imaging Tinnitus physiopathology Tinnitus pathology Amygdala diagnostic imaging Amygdala pathology Amygdala physiopathology Magnetic Resonance Imaging
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Hum Brain Mapp] 2024 Jun 01; Vol. 45 (8), pp. e26712. MeSH Terms: Tinnitus* / diagnostic imaging ; Tinnitus* / physiopathology ; Tinnitus* / pathology ; Amygdala* / diagnostic imaging ; Amygdala* / pathology ; Amygdala* / physiopathology ; Magnetic Resonance Imaging* ; Humans ; Male ; Female ; Adult ; Middle Aged ; Gray Matter / diagnostic imaging ; Gray Matter / pathology ; Gray Matter / physiopathology ; Mood Disorders / diagnostic imaging ; Mood Disorders / etiology ; Mood Disorders / physiopathology ; Mood Disorders / pathology References: Front Neural Circuits. 2015 Oct 29;9:67. (PMID: 26578894) ; Neuropharmacology. 2020 Jun 15;170:108052. (PMID: 32188569) ; HNO. 2023 Oct;71(10):648-655. (PMID: 37581622) ; Prog Neuropsychopharmacol Biol Psychiatry. 2017 Oct 3;79(Pt B):249-257. (PMID: 28689008) ; Hum Brain Mapp. 2024 Jun 1;45(8):e26712. (PMID: 38798104) ; J Neurosci. 2009 Feb 11;29(6):1860-73. (PMID: 19211893) ; Netw Neurosci. 2018 Oct 01;3(1):67-89. (PMID: 30793074) ; Trends Hear. 2019 Jan-Dec;23:2331216519830237. (PMID: 30995887) ; Psychiatry Res. 2010 Apr 30;182(1):67-72. (PMID: 20227858) ; Aust J Gen Pract. 2018 Apr;47(4):205-208. (PMID: 29621860) ; Handb Clin Neurol. 2022;187:359-380. (PMID: 35964983) ; Hum Brain Mapp. 2019 Jun 15;40(9):2723-2735. (PMID: 30829454) ; Handb Clin Neurol. 2015;129:409-31. (PMID: 25726282) ; Neuroradiology. 2018 Nov;60(11):1203-1211. (PMID: 30206673) ; Hum Brain Mapp. 2013 Dec;34(12):3247-66. (PMID: 22806915) ; J Magn Reson Imaging. 2024 Feb;59(2):361-375. (PMID: 37352130) ; Neuroscience. 2019 Jun 1;408:31-45. (PMID: 30946875) ; Open Neuroimag J. 2010 Jun 30;4:16-25. (PMID: 20922048) ; Front Neurosci. 2021 Feb 11;15:621145. (PMID: 33642982) ; Hum Brain Mapp. 2021 Feb 15;42(3):753-765. (PMID: 33098363) ; BMC Psychiatry. 2012 Sep 14;12:141. (PMID: 22978466) ; Int J Audiol. 2016 Nov;55(11):605-15. (PMID: 27387463) ; Neuroradiology. 2018 Nov;60(11):1193-1201. (PMID: 30159629) ; Biomolecules. 2021 May 31;11(6):. (PMID: 34072960) ; Brain Commun. 2023 Oct 07;5(5):fcad261. (PMID: 37869577) ; Discoveries (Craiova). 2021 Sep 30;9(3):e137. (PMID: 35350720) ; J Clin Psychol. 1971 Apr;27(2):247-8. (PMID: 5100681) ; Brain Res. 2018 Jan 15;1679:64-74. (PMID: 29158175) ; Arch Otolaryngol Head Neck Surg. 1996 Feb;122(2):143-8. (PMID: 8630207) ; Front Aging Neurosci. 2016 Jul 08;8:174. (PMID: 27458377) ; Clin Neuroradiol. 2017 Jun;27(2):221-230. (PMID: 26490370) ; CNS Neurosci Ther. 2023 Dec;29(12):4070-4081. (PMID: 37392024) ; Nat Hum Behav. 2022 Dec;6(12):1705-1722. (PMID: 36138220) ; Front Neurol. 2022 Dec 01;13:986805. (PMID: 36530635) ; Hear Res. 2016 Apr;334:49-57. (PMID: 26299843) ; J Stroke Cerebrovasc Dis. 2018 Oct;27(10):2613-2622. (PMID: 30072176) ; Int J Mol Sci. 2023 Jun 08;24(12):. (PMID: 37373034) ; J Integr Neurosci. 2022 Jun 21;21(4):116. (PMID: 35864767) ; Int J Audiol. 2012 May;51(5):413-7. (PMID: 22283490) ; AJNR Am J Neuroradiol. 2019 Oct;40(10):1638-1641. (PMID: 31558496) ; Am J Nucl Med Mol Imaging. 2021 Apr 15;11(2):107-142. (PMID: 34079640) ; Hum Brain Mapp. 2022 Jul;43(10):3245-3256. (PMID: 35332961) ; AJNR Am J Neuroradiol. 2018 Aug;39(8):1390-1399. (PMID: 29348136) ; J Neurosci. 2017 May 17;37(20):5051-5064. (PMID: 28411274) ; Hear Res. 2016 Mar;333:255-265. (PMID: 26342399) ; Lancet. 2013 Nov 9;382(9904):1600-7. (PMID: 23827090) ; Neurosci Biobehav Rev. 2015 Apr;51:77-86. (PMID: 25597656) ; Brain Connect. 2016 Feb;6(1):84-93. (PMID: 26477359) ; Front Syst Neurosci. 2020 Jan 24;13:88. (PMID: 32038184) ; Front Aging Neurosci. 2017 Feb 21;9:31. (PMID: 28270764) ; Neuropsychopharmacology. 2022 Jan;47(1):260-275. (PMID: 34400783) ; Front Neurosci. 2020 Jun 30;14:592. (PMID: 32714128) ; Brain Imaging Behav. 2022 Dec;16(6):2725-2734. (PMID: 36327020) ; Elife. 2015 May 12;4:e06576. (PMID: 25962854) Grant Information: 20377751D S & T Program of Hebei; 61931013 National Natural Science Foundation of China; 82302284 National Natural Science Foundation of China; [2015] 160 Beijing Scholars Program; 2023-ZZ-014 Beijing Postdoctoral Research Foundation; yybsh2022003 Postdoctoral launch project of the Beijing Friendship Hospital Contributed Indexing: Keywords: affective dysfunction; amygdala; functional connectivity; multimodal magnetic resonance imaging; structural and functional reorganization; tinnitus Entry Date(s): Date Created: 20240527 Date Completed: 20240527 Latest Revision: 20240529 Update Code: 20240529 PubMed Central ID: PMC11128775

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Amygdala structural and functional reorganization as an indicator of affective dysfunction in patients with tinnitus.