Peripheral CX3CR1 <superscript>+</superscript> T cells combined with PD-1 blockade therapy potentiates the anti-tumor efficacy for lung cancer.
In: Oncoimmunology, Jg. 13 (2024-05-22), Heft 1, S. 2355684
Online
academicJournal
Zugriff:
Identifying tumor-relevant T cell subsets in the peripheral blood (PB) has become a potential strategy for cancer treatment. However, the subset of PB that could be used to treat cancer remains poorly defined. Here, we found that the CX3CR1 + T cell subset in the blood of patients with lung cancer exhibited effector properties and had a higher TCR matching ratio with tumor-infiltrating lymphocytes (TILs) compared to CX3CR1 - T cells, as determined by paired single-cell RNA and TCR sequencing. Meanwhile, the anti-tumor activities, effector cytokine production, and mitochondrial function were enhanced in CX3CR1 + T cells both in vitro and in vivo . However, in the co-culture system of H322 cells with T cells, the percentages of apoptotic cells and Fas were substantially higher in CX3CR1 + T cells than those in CX3CR1 - T cells. Fas-mediated apoptosis was rescued by treatment with an anti-PD-1 antibody. Accordingly, the combination of adoptive transfer of CX3CR1 + T cells and anti-PD-1 treatment considerably decreased Fas expression and improved the survival of lung xenograft mice. Moreover, an increased frequency of CX3CR1 + T cells in the PB correlated with a better response and prolonged survival of patients with lung cancer who received anti-PD-1 therapy. These findings indicate the promising potential of adoptive transfer of peripheral CX3CR1 + T cells as an individual cancer immunotherapy.
Competing Interests: No potential conflict of interest was reported by the author(s).
(© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.)
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Peripheral CX3CR1 <superscript>+</superscript> T cells combined with PD-1 blockade therapy potentiates the anti-tumor efficacy for lung cancer.
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Autor/in / Beteiligte Person: | Li, C ; Zhang, Z ; Cai, Q ; Zhao, Q ; Wu, H ; Li, J ; Liu, Y ; Zhao, X ; Liu, J ; Ping, Y ; Shan, J ; Yang, S ; Zhang, Y |
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Zeitschrift: | Oncoimmunology, Jg. 13 (2024-05-22), Heft 1, S. 2355684 |
Veröffentlichung: | 2015- : Philadelphia, PA : Taylor & Francis ; <i>Original Publication</i>: Austin, TX : Landes Bioscience, 2024 |
Medientyp: | academicJournal |
ISSN: | 2162-402X (electronic) |
DOI: | 10.1080/2162402X.2024.2355684 |
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