Einzeltreffer — DigiBib

Sacubitril/valsartan has been highly recognized as a treatment for Chronic heart failure (CHF). Its potential cardioprotective benefits and mechanisms, however, remain to be explored. Metabolomics can be used to identify the metabolic characteristics and related markers, as well as the influence of drugs, thereby opening up the new mechanism for sacubitril/valsartan therapy in CHF disease. In this study, the ligation of left anterior descending and exhaustive swimming were used to induce a rat model of CHF after myocardial infarction. The efficacy was appraised with echocardiography, serum NT-proBNP, and histopathologica. UPLC-Q/TOF-MS combined with multivariate statistical analysis approach were used to analyze the effect of sacubitril/valsartan on CHF rats. RT-qPCR and western blot were performed to investigate the tryptophan/kynurenine metabolism pathway. Accordingly, the basal cardiac function were increased, while the serum NT-proBNP and collagen volume fraction decreased in CHF rats with sacubitril/valsartan. Sacubitril/valsartan regulated the expression of kynurenine et.al 8 metabolomic biomarkers in CHF rats serum, and it contributed to the cardioprotective effects through tryptophan metabolism pathway. In addition, the mRNA and protein expression of the indoleamine 2,3-dioxygenase (IDO) in the myocardial tissue of CHF rats, were down-regulated by sacubitril/valsartan, which was the same with the IL-1β, IFN-γ, TNF-α, COX-2, and IL-6 mRNA expression, and IL-1β, IFN-γ, and TNF-α expression in serum. In conclusion, sacubitril/valsartan can ameliorate cardiac function and ventricular remodeling in CHF rats, at least in part through inhibition of tryptophan/kynurenine metabolism.

Titel:	Sacubitril/valsartan ameliorates cardiac function and ventricular remodeling in CHF rats via the inhibition of the tryptophan/kynurenine metabolism and inflammation.
Autor/in / Beteiligte Person:	Gan, J ; Wang, Y ; Deng, Y ; Zhang, J ; Wang, S ; Jiang, X ; Guo, M ; Song, L
Link:	Full Text Finder (Volltext)
Zeitschrift:	Scientific reports, Jg. 14 (2024-05-29), Heft 1, S. 12377
Veröffentlichung:	London : Nature Publishing Group, copyright 2011-, 2024
Medientyp:	academicJournal
ISSN:	2045-2322 (electronic)
DOI:	10.1038/s41598-024-62472-7
Schlagwort:	Animals Rats Male Disease Models, Animal Natriuretic Peptide, Brain metabolism Natriuretic Peptide, Brain blood Rats, Sprague-Dawley Aminobutyrates pharmacology Valsartan pharmacology Drug Combinations Biphenyl Compounds pharmacology Ventricular Remodeling drug effects Kynurenine metabolism Heart Failure drug therapy Heart Failure metabolism Tryptophan metabolism Tetrazoles pharmacology Inflammation drug therapy Inflammation metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Sci Rep] 2024 May 29; Vol. 14 (1), pp. 12377. <i>Date of Electronic Publication: </i>2024 May 29. MeSH Terms: Aminobutyrates* / pharmacology ; Valsartan* / pharmacology ; Drug Combinations* ; Biphenyl Compounds* / pharmacology ; Ventricular Remodeling* / drug effects ; Kynurenine* / metabolism ; Heart Failure* / drug therapy ; Heart Failure* / metabolism ; Tryptophan* / metabolism ; Tetrazoles* / pharmacology ; Inflammation* / drug therapy ; Inflammation* / metabolism ; Animals ; Rats ; Male ; Disease Models, Animal ; Natriuretic Peptide, Brain / metabolism ; Natriuretic Peptide, Brain / blood ; Rats, Sprague-Dawley References: Am J Clin Nutr. 2021 Nov 8;114(5):1646-1654. (PMID: 34291275) ; Circ Heart Fail. 2021 Dec;14(12):e008597. (PMID: 34807713) ; BMC Cardiovasc Disord. 2021 Jul 26;21(1):353. (PMID: 34311709) ; Front Cardiovasc Med. 2021 May 05;8:650278. (PMID: 34026868) ; Basic Clin Pharmacol Toxicol. 2022 Apr;130(4):425-438. (PMID: 35128801) ; ESC Heart Fail. 2023 Feb;10(1):453-464. (PMID: 36303443) ; Am J Cardiovasc Drugs. 2021 May;21(3):267-270. (PMID: 33063249) ; Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19725-30. (PMID: 22106299) ; Cardiovasc Res. 2021 Jan 21;117(2):423-434. (PMID: 32666082) ; Int J Tryptophan Res. 2019 Aug 21;12:1178646919868978. (PMID: 31488951) ; Sci Rep. 2019 Jun 11;9(1):8491. (PMID: 31186442) ; Cardiovasc Drugs Ther. 2020 Oct;34(5):629-640. (PMID: 32444995) ; Sci Rep. 2020 Sep 24;10(1):15701. (PMID: 32973263) ; Scand J Trauma Resusc Emerg Med. 2019 May 22;27(1):56. (PMID: 31118076) ; Handb Exp Pharmacol. 2017;243:133-165. (PMID: 28004291) ; Nat Rev Cardiol. 2016 Jun;13(6):368-78. (PMID: 26935038) ; Clin Pharmacokinet. 2017 Dec;56(12):1461-1478. (PMID: 28417439) ; J Infect Dis. 2020 Jan 14;221(3):419-427. (PMID: 31538186) ; Anatol J Cardiol. 2021 Nov;25(11):821-828. (PMID: 34734816) ; Eur Heart J Case Rep. 2022 Sep 23;6(10):ytac396. (PMID: 36267296) ; Trends Immunol. 2013 Mar;34(3):137-43. (PMID: 23103127) ; Circ Heart Fail. 2016 Jan;9(1):. (PMID: 26754626) ; J Biol Chem. 1996 Jul 19;271(29):17247-52. (PMID: 8663541) ; N Engl J Med. 2019 Oct 24;381(17):1609-1620. (PMID: 31475794) ; JAMA. 2020 Sep 8;324(10):1015. (PMID: 32749448) ; Cancer Immunol Immunother. 2009 Jan;58(1):153-7. (PMID: 18418598) ; Front Immunol. 2018 May 29;9:1051. (PMID: 29896191) ; Circ Res. 2018 Apr 27;122(9):1238-1258. (PMID: 29700070) ; Am J Physiol Heart Circ Physiol. 2011 Sep;301(3):H994-1003. (PMID: 21685270) ; Front Pharmacol. 2021 Nov 19;12:604017. (PMID: 34867310) ; J Am Coll Cardiol. 2016 Dec 27;68(25):2850-2870. (PMID: 28007146) ; Nat Rev Drug Discov. 2018 Aug;17(8):588-606. (PMID: 30026524) ; J Clin Pharmacol. 2010 Apr;50(4):401-14. (PMID: 19934029) ; Oxid Med Cell Longev. 2021 Jul 30;2021:7328437. (PMID: 34373768) ; Drugs. 2019 Sep;79(14):1543-1556. (PMID: 31432436) ; Heart Fail Rev. 2017 May;22(3):279-288. (PMID: 28378286) ; Cardiovasc Diabetol. 2021 Jul 23;20(1):150. (PMID: 34301253) ; Circulation. 2023 Jan 24;147(4):338-355. (PMID: 36440584) ; Trends Endocrinol Metab. 2020 Mar;31(3):181-191. (PMID: 31866216) ; JACC Basic Transl Sci. 2017 Dec 25;2(6):655-668. (PMID: 30062181) ; Circulation. 2022 Feb 22;145(8):e153-e639. (PMID: 35078371) ; Pharmacol Ther. 2021 Nov;227:107863. (PMID: 33894277) ; J Card Fail. 2018 Apr;24(4):266-275. (PMID: 29325796) ; Science. 2017 Jul 28;357(6349):. (PMID: 28751584) ; Indian Heart J. 2018 Jul;70 Suppl 1:S102-S110. (PMID: 30122239) ; Biochem J. 1985 Sep 15;230(3):635-8. (PMID: 3877502) ; Psychoneuroendocrinology. 2018 Aug;94:1-10. (PMID: 29734055) ; Biochem J. 1980 Mar 15;186(3):977-86. (PMID: 7396847) Grant Information: 21JCQNJC01170 Tianjin Natural Science Foundation; 81774071 National Natural Science Foundation of China Substance Nomenclature: 0 (Aminobutyrates) ; WB8FT61183 (sacubitril and valsartan sodium hydrate drug combination) ; 80M03YXJ7I (Valsartan) ; 0 (Drug Combinations) ; 0 (Biphenyl Compounds) ; 343-65-7 (Kynurenine) ; 8DUH1N11BX (Tryptophan) ; 0 (Tetrazoles) ; 114471-18-0 (Natriuretic Peptide, Brain) Entry Date(s): Date Created: 20240529 Date Completed: 20240530 Latest Revision: 20240601 Update Code: 20240601 PubMed Central ID: PMC11136956

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

Sacubitril/valsartan ameliorates cardiac function and ventricular remodeling in CHF rats via the inhibition of the tryptophan/kynurenine metabolism and inflammation.