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Introduction: The relevance of tubulo-interstitial involvement for kidney prognosis has recently been emphasized, but validated biomarkers for predicting histology are still lacking. The aim of our study was to evaluate different serum and urinary markers of tubular damage in patients with lupus nephritis (LN) and to correlate them with kidney histopathology.

Methods: A single-center retrospective study was conducted from January 2016 to December 2021. Serum and urine samples were collected on the same day of kidney biopsy and correlated with histologic data from a cohort of 15 LN patients. We analyzed the following urinary markers, adjusted for urine creatinine: beta 2-microglobulin, alpha 1-microglobulin, NGAL, uKIM-1, MCP-1, uDKK-3, and uUMOD. The serum markers sKIM-1 and sUMOD were also analyzed.

Results: A positive and strong correlation was observed between the degree of interstitial fibrosis (rho = 0.785, p = .001) and tubular atrophy (rho = 0.781, p = .001) and the levels of uDKK3. uUMOD also showed an inverse and moderate correlation with interstitial fibrosis (rho = -0.562, p = .037) and tubular atrophy (rho = -0.694, p = .006). Patients with >10% cortical interstitial inflammation had higher levels of uKIM-1 [4.9 (3.9, 5.5) vs. 0.8 (0.6, 1.5) mcg/mg, p = .001], MCP-1 [3.8 (2. 3, 4.2) vs. 0.7 (0.3, 1.2) mcg/mg, p = .001], sKIM-1 [9.2 (5.9, 32.7) vs. 1.4 (0, 3.5) pg/mL, p = .001], and lower sUMOD [8.7 (0, 39.7) vs. 46.1 (35.7, 53) ng/mL, p = .028].

Conclusion: The use of specific urinary and serum biomarkers of tubular dysfunction or injury may help to predict certain histologic parameters in LN patients.

Titel:	Tubular biomarkers and histology in lupus nephritis.
Autor/in / Beteiligte Person:	Carbayo, J ; Verdalles, Ú ; Díaz-Crespo, F ; Lázaro, A ; González-Nicolás, M ; Arroyo, D ; Blanco, D ; Redondo, VC ; García-Gámiz, M ; Goicoechea, M
Link:	Full Text Finder (Volltext)
Zeitschrift:	International journal of rheumatic diseases, Jg. 27 (2024-06-01), Heft 6, S. e15210
Veröffentlichung:	[Oxford, UK] : Wiley on behalf of the Asia Pacific League of Associations for Rheumatology, 2024
Medientyp:	academicJournal
ISSN:	1756-185X (electronic)
DOI:	10.1111/1756-185X.15210
Schlagwort:	Humans Female Male Retrospective Studies Adult Biopsy Predictive Value of Tests Middle Aged Fibrosis Atrophy Young Adult Lupus Nephritis urine Lupus Nephritis blood Lupus Nephritis pathology Lupus Nephritis diagnosis Biomarkers blood Biomarkers urine Kidney Tubules pathology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Int J Rheum Dis] 2024 Jun; Vol. 27 (6), pp. e15210. MeSH Terms: Lupus Nephritis* / urine ; Lupus Nephritis* / blood ; Lupus Nephritis* / pathology ; Lupus Nephritis* / diagnosis ; Biomarkers* / blood ; Biomarkers* / urine ; Kidney Tubules* / pathology ; Humans ; Female ; Male ; Retrospective Studies ; Adult ; Biopsy ; Predictive Value of Tests ; Middle Aged ; Fibrosis ; Atrophy ; Young Adult References: Dörner T, Furie R. Novel paradigms in systemic lupus erythematosus. Lancet. 2019;393(10188):2344‐2358. ; Bajema IM, Wilhelmus S, Alpers CE, et al. Revision of the International Society of Nephrology/Renal Pathology Society classification for lupus nephritis: clarification of definitions, and modified National Institutes of Health activity and chronicity indices. Kidney Int. 2018;93(4):789‐796. ; Yung S, Chan TM. 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Clin Rheumatol. 2023;42(1):83‐92. ; Zhao WT, Huang JW, Sun PP, et al. Diagnostic roles of urinary kidney injury molecule 1 and soluble C5b‐9 in acute tubulointerstitial nephritis. Am J Physiol Renal Physiol. 2019;317(3):F584‐F592. ; Morii T, Fujita H, Narita T, et al. Association of monocyte chemoattractant protein‐1 with renal tubular damage in diabetic nephropathy. J Diabetes Complicat. 2003;17(1):11‐15. ; Steubl D, Schneider MP, Meiselbach H, et al. Association of Serum Uromodulin with death, cardiovascular events, and kidney failure in CKD. Clin J Am Soc Nephrol. 2020;15(5):616‐624. Grant Information: RD 21/0005/029 RICORS 2040 (KIDNEY DISEASE) project Contributed Indexing: Keywords: cortical interstitial inflammation; interstitial fibrosis; lupus nephritis; tubule biomarkers; uDKK3; uromodulin Substance Nomenclature: 0 (Biomarkers) Entry Date(s): Date Created: 20240605 Date Completed: 20240605 Latest Revision: 20240605 Update Code: 20240606

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Tubular biomarkers and histology in lupus nephritis.