A Computational Framework for the Administration of 5-Aminovulinic Acid Before Glioblastoma Surgery.
In: Bulletin of mathematical biology, Jg. 86 (2024-06-06), Heft 7, S. 83
Online
academicJournal
Zugriff:
5-Aminolevulinic Acid (5-ALA) is the only fluorophore approved by the FDA as an intraoperative optical imaging agent for fluorescence-guided surgery in patients with glioblastoma. The dosing regimen is based on rodent tests where a maximum signal occurs around 6 h after drug administration. Here, we construct a computational framework to simulate the transport of 5-ALA through the stomach, blood, and brain, and the subsequent conversion to the fluorescent agent protoporphyrin IX at the tumor site. The framework combines compartmental models with spatially-resolved partial differential equations, enabling one to address questions regarding quantity and timing of 5-ALA administration before surgery. Numerical tests in two spatial dimensions indicate that, for tumors exceeding the detection threshold, the time to peak fluorescent concentration is 2-7 h, broadly consistent with the current surgical guidelines. Moreover, the framework enables one to examine the specific effects of tumor size and location on the required dose and timing of 5-ALA administration before glioblastoma surgery.
(© 2024. The Author(s), under exclusive licence to the Society for Mathematical Biology.)
Titel: |
A Computational Framework for the Administration of 5-Aminovulinic Acid Before Glioblastoma Surgery.
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Autor/in / Beteiligte Person: | Zeng, J ; Moore, NJ |
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Zeitschrift: | Bulletin of mathematical biology, Jg. 86 (2024-06-06), Heft 7, S. 83 |
Veröffentlichung: | New York, NY : Springer ; <i>Original Publication</i>: New York, Pergamon Press., 2024 |
Medientyp: | academicJournal |
ISSN: | 1522-9602 (electronic) |
DOI: | 10.1007/s11538-024-01312-1 |
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