Sonstiges: |
- Nachgewiesen in: MEDLINE
- Sprachen: English
- Publication Type: Journal Article
- Language: English
- [Drug Dev Res] 2024 Jun; Vol. 85 (4), pp. e22219.
- MeSH Terms: Alkaloids* / pharmacology ; Alkaloids* / therapeutic use ; Quinolizines* / pharmacology ; Quinolizines* / therapeutic use ; Sepsis* / drug therapy ; Sepsis* / complications ; Sepsis* / metabolism ; NF-kappa B* / metabolism ; HMGB1 Protein* / metabolism ; HMGB1 Protein* / antagonists & inhibitors ; Receptor for Advanced Glycation End Products* / metabolism ; Signal Transduction* / drug effects ; Inflammation* / drug therapy ; Inflammation* / metabolism ; Lipopolysaccharides* ; Animals ; Humans ; Mice ; Male ; Anti-Inflammatory Agents / pharmacology ; Anti-Inflammatory Agents / therapeutic use ; THP-1 Cells ; Mice, Inbred C57BL ; Macrophages / drug effects ; Macrophages / metabolism ; Matrines
- References: Achouiti, A., de Vos, A. F., de Beer, R., Florquin, S., van 't Veer, C., & van der Poll, T. (2013). Limited role of the receptor for advanced glycation end products during streptococcus pneumoniae bacteremia. Journal of Innate Immunity, 5, 603–612. ; Cannizzaro, L., Rossoni, G., Savi, F., Altomare, A., Marinello, C., Saethang, T., Carini, M., Payne, D. M., Pisitkun, T., Aldini, G., & Leelahavanichkul, A. (2017). Regulatory landscape of AGE‐RAGE‐oxidative stress axis and its modulation by PPARγ activation in high fructose diet‐induced metabolic syndrome. Nutrition & Metabolism, 14, 5. ; Chakraborty, R., Bhatt, K. H., & Sodhi, A. (2013). High mobility group box 1 protein synergizes with lipopolysaccharide and peptidoglycan for nitric oxide production in mouse peritoneal macrophages in vitro. Molecular Immunology, 54, 48–57. ; Chen, Q., Duan, X., & Fan, H., et al. (2017a). Oxymatrine protects against DSS‐induced colitis via inhibiting the PI3K/AKT signaling pathway. International Immunopharmacology, 53, 149–157. ; Chen, Q., Zhou, H., & Yang, Y., et al. (2017b). Investigating the potential of oxymatrine as a psoriasis therapy. Chemico‐Biological Interactions, 271, 59–66. ; Christaki, E., Lazaridis, N., & Opal, S. M. (2012). Receptor for advanced glycation end products in bacterial infection: Is there a role for immune modulation of receptor for advanced glycation end products in the treatment of sepsis? Current Opinion in Infectious Diseases, 25(3), 304–311. ; Cui, L., Cai, Y., Cheng, W., Liu, G., Zhao, J., Cao, H., Tao, H., Wang, Y., Yin, M., Liu, T., Liu, Y., Huang, P., Liu, Z., Li, K., & Zhao, B. (2017). A novel, multi‐target natural drug candidate, matrine, improves cognitive deficits in alzheimer's disease transgenic mice by inhibiting Aβ aggregation and blocking the RAGE/Aβ axis. Molecular Neurobiology, 54, 1939–1952. ; Fleischmann‐Struzek, C., Mellhammar, L., Rose, N., Cassini, A., Rudd, K. E., Schlattmann, P., Allegranzi, B., & Reinhart, K. (2020). Incidence and mortality of hospital‐ and ICU‐treated sepsis: Results from an updated and expanded systematic review and meta‐analysis. Intensive Care Medicine, 46, 1552–1562. ; Fritz, G. (2011). RAGE: A single receptor fits multiple ligands. Trends in Biochemical Sciences, 36, 625–632. ; Guglielmotto, M., Aragno, M., Tamagno, E., Vercellinatto, I., Visentin, S., Medana, C., Catalano, M. G., Smith, M. A., Perry, G., Danni, O., Boccuzzi, G., & Tabaton, M. (2012). AGEs/RAGE complex upregulates BACE1 via NF‐κB pathway activation. Neurobiology of Aging, 33, 196.e13–196.e27. ; Guirgis, F. W., Brakenridge, S., Sutchu, S., Khadpe, J. D., Robinson, T., Westenbarger, R., Topp, S. T., Kalynych, C. J., Reynolds, J., Dodani, S., Moore, F. A., & Jones, A. E. (2016). The long‐term burden of severe sepsis and septic shock: Sepsis recidivism and organ dysfunction. Journal of Trauma and Acute Care Surgery, 81, 525–532. ; Guirgis, F. W., Khadpe, J. D., Kuntz, G. M., Wears, R. L., Kalynych, C. J., & Jones, A. E. (2014). Persistent organ dysfunction after severe sepsis: A systematic review. Journal of Critical Care, 29, 320–326. ; Halim, C. E., Xinjing, S. L., Fan, L., Bailey Vitarbo, J., Arfuso, F., Tan, C. H., Narula, A. S., Kumar, A. P., Sethi, G., & Ahn, K. S. (2019). Anti‐cancer effects of oxymatrine are mediated through multiple molecular mechanism(s) in tumor models. Pharmacological Research, 147, 104327. ; Hashemian, S. M., Pourhanifeh, M. H., Fadaei, S., Velayati, A. A., Mirzaei, H., & Hamblin, M. R. (2020). Non‐coding RNAs and exosomes: Their role in the pathogenesis of sepsis. Molecular Therapy‐Nucleic Acids, 21, 51–74. ; He, M., Wu, Y., Wang, M., Chen, W., & Jiang, J. (2016). Meta‐analysis of the clinical value of oxymatrine on sustained virological response in chronic hepatitis B. Annals of hepatology, 15(4), 482–491. ; Hendawy, N., Salaheldin, T. H., & Abuelezz, S. A. (2023). PCSK9 inhibition reduces depressive like behavior in CUMS‐exposed rats: Highlights on HMGB1/RAGE/TLR4 pathway, NLRP3 inflammasome complex and IDO‐1. Journal of Neuroimmune Pharmacology, 18, 195–207. ; Huang, M., Cai, S., & Su, J. (2019). The pathogenesis of sepsis and potential therapeutic targets. International Journal of Molecular Sciences, 20, 5376. ; Huang, W. C., Chan, C. C., Wu, S. J., Chen, L. C., Shen, J. J., Kuo, M. L., Chen, M. C., & Liou, C. J. (2014). Matrine attenuates allergic airway inflammation and eosinophil infiltration by suppressing eotaxin and Th2 cytokine production in asthmatic mice. Journal of Ethnopharmacology, 151(1), 470–477. ; Hudson, B. I., & Lippman, M. E. (2018). Targeting RAGE signaling in inflammatory disease. Annual Review of Medicine, 69, 349–364. ; Jarczak, D., & Kluge, S. (2021). Nierhaus A. Sepsis‐pathophysiology and therapeutic concepts. Front Med (Lausanne), 8, 628302. ; Khalid, M., Petroianu, G., & Adem, A. (2022). Advanced glycation end products and diabetes mellitus: Mechanisms and perspectives. Biomolecules, 12, 542. ; Klausen, H. H., Bodilsen, A. C., Petersen, J., Bandholm, T., Haupt, T., Sivertsen, D. M., & Andersen, O. (2017). How inflammation underlies physical and organ function in acutely admitted older medical patients. Mechanisms of Ageing and Development, 164, 67–75. ; Lan, X., Zhao, J., Zhang, Y., Chen, Y., Liu, Y., & Xu, F. (2020). Oxymatrine exerts organ‐ and tissue‐protective effects by regulating inflammation, oxidative stress, apoptosis, and fibrosis: From bench to bedside. Pharmacological Research, 151, 104541. ; Lee, S.‐A., Kwak, M. S., Kim, S., & Shin, J.‐S. (2014). The role of high mobility group box 1 in innate immunity. Yonsei Medical Journal, 55, 1165. ; Li, J.‐Z., Wu, J.‐H., Yu, S.‐Y., Shao, Q.‐R., & Dong, X.‐M. (2013). Inhibitory effects of paeoniflorin on lysophosphatidylcholine‐induced inflammatory factor production in human umbilical vein endothelial cells. International Journal of Molecular Medicine, 31, 493–497. ; Liu, D., Huang, S. Y., Sun, J. H., Zhang, H. C., Cai, Q. L., Gao, C., Li, L., Cao, J., Xu, F., Zhou, Y., Guan, C. X., Jin, S. W., Deng, J., Fang, X. M., Jiang, J. X., & Zeng, L. (2022). Sepsis‐induced immunosuppression: Mechanisms, diagnosis and current treatment options. Military Medical Research, 9(1), 56. ; Mao, Y. M. (2004). Capsule oxymatrine in treatment of hepatic fibrosis due to chronic viral hepatitis: A randomized, double blind, placebo‐controlled, multicenter clinical study. World Journal of Gastroenterology, 10(22), 3269–3273. ; Ostrand‐Rosenberg, S., Huecksteadt, T., & Sanders, K. (2023). The receptor for advanced glycation endproducts (RAGE) and its ligands S100A8/A9 and high mobility group box protein 1 (HMGB1) are key regulators of myeloid‐derived suppressor cells. Cancers, 15, 1026. ; Ott, C., Jacobs, K., Haucke, E., Navarrete Santos, A., Grune, T., & Simm, A. (2014). Role of advanced glycation end products in cellular signaling. Redox Biology, 2, 411–429. ; Pool, R., Gomez, H., & Kellum, J. A. (2018). Mechanisms of organ dysfunction in sepsis. Critical Care Clinics, 34, 63–80. ; Ren, Y., Li, L., Wang, M.‐M., Cao, L. P., Sun, Z. R., Yang, Z. Z., Zhang, W., Zhang, P., & Nie, S. N. (2021). Pravastatin attenuates sepsis‐induced acute lung injury through decreasing pulmonary microvascular permeability via inhibition of Cav‐1/eNOS pathway. International Immunopharmacology, 100, 108077. ; Rudd, K. E., Johnson, S. C., Agesa, K. M., Shackelford, K. A., Tsoi, D., Kievlan, D. R., Colombara, D. V., Ikuta, K. S., Kissoon, N., Finfer, S., Fleischmann‐Struzek, C., Machado, F. R., Reinhart, K. K., Rowan, K., Seymour, C. W., Watson, R. S., West, T. E., Marinho, F., Hay, S. I., … Naghavi, M. (2020). Global, regional, and national sepsis incidence and mortality, 1990–2017: Analysis for the global burden of disease study. The Lancet, 395, 200–211. ; Sekino, N., Selim, M., & Shehadah, A. (2022). Sepsis‐associated brain injury: Underlying mechanisms and potential therapeutic strategies for acute and long‐term cognitive impairments. Journal of Neuroinflammation, 19, 101. ; Shao, Y., Shao, X., He, J., Cai, Y., Zhao, J., Chen, F., Tao, H., Yin, Z., Tan, X., He, Y., Lin, Y., Li, K., & Cui, L. (2017). The promoter polymorphisms of receptor for advanced glycation end products were associated with the susceptibility and progression of sepsis. Clinical Genetics, 91, 564–575. ; Shi, H. J., Zhou, H., Ma, A. L., Wang, L., Gao, Q., Zhang, N., Song, H. B., Bo, K. P., & Ma, W. (2019). Oxymatrine therapy inhibited epidermal cell proliferation and apoptosis in severe plaque psoriasis. British Journal of Dermatology, 181(5), 1028–1037. ; Singer, M., Deutschman, C. S., Seymour, C. W., Shankar‐Hari, M., Annane, D., Bauer, M., Bellomo, R., Bernard, G. R., Chiche, J. D., Coopersmith, C. M., Hotchkiss, R. S., Levy, M. M., Marshall, J. C., Martin, G. S., Opal, S. M., Rubenfeld, G. D., van der Poll, T., Vincent, J. L., & Angus, D. C. (2016). The third international consensus definitions for sepsis and septic shock (Sepsis‐3). Journal of the American Medical Association, 315, 801. ; Singh, H., & Agrawal, D. K. (2022a). Therapeutic potential of targeting the HMGB1/RAGE axis in inflammatory diseases. Molecules, 27, 7311. ; Singh, H., & Agrawal, D. K. (2022b). Therapeutic potential of targeting the HMGB1/RAGE axis in inflammatory diseases. Molecules, 27(21), 7311. ; Sun, M., Cao, H., Sun, L., Dong, S., Bian, Y., Han, J., Zhang, L., Ren, S., Hu, Y., Liu, C., Xu, L., & Liu, P. (2012). Antitumor activities of kushen: Literature review. Evidence‐Based Complementary and Alternative Medicine, 2012, 1–11. ; Taylor, M. D., Fernandes, T. D., Yaipen, O., Higgins, C. E., Capone, C. A., Leisman, D. E., Nedeljkovic‐Kurepa, A., Abraham, M. N., Brewer, M. R., & Deutschman, C. S. (2022). T cell activation and IFNγ modulate organ dysfunction in LPS‐mediated inflammation. Journal of Leukocyte Biology, 112, 221–232. ; Dellinger, R. P., Levy, M. M., Rhodes, A., Annane, D., Gerlach, H., Opal, S. M., Sevransky, J. E., Sprung, C. L., Douglas, I. S., Jaeschke, R., Osborn, T. M., Nunnally, M. E., Townsend, S. R., Reinhart, K., Kleinpell, R. M., Angus, D. C., Deutschman, C. S., Machado, F. R., Rubenfeld, G. D., … Moreno, R., The Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup*. (2013). Surviving sepsis campaign: International guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Medicine, 39, 165–228. ; Ullah, M. A., Loh, Z., Gan, W. J., Zhang, V., Yang, H., Li, J. H., Yamamoto, Y., Schmidt, A. M., Armour, C. L., Hughes, J. M., Phipps, S., & Sukkar, M. B. (2014). Receptor for advanced glycation end products and its ligand high‐mobility group box‐1 mediate allergic airway sensitization and airway inflammation. Journal of Allergy and Clinical Immunology, 134, 440–450.e3. ; Wang, Y., Shou, Z., Fan, H., Xu, M., Chen, Q., Tang, Q., Liu, X., Wu, H., Zhang, M., Yu, T., Deng, S., & Liu, Y. (2019). Protective effects of oxymatrine against DSS‐induced acute intestinal inflammation in mice via blocking the RhoA/ROCK signaling pathway. Bioscience Reports, 39(7), BSR20182297. ; Xu, J., Wang, K.‐Q., Xu, W.‐H., Li, Y. H., Qi, Y., Wu, H. Y., Li, J. Z., He, Z. G., Hu, H. G., Wang, Y., & Zhang, J. P. (2016). The matrine derivate MASM prolongs survival, attenuates inflammation, and reduces organ injury in murine established lethal sepsis. Journal of Infectious Diseases, 214, 1762–1772. ; Xu, M., Shao, Y., Lin, K., Liu, Y., Lin, Y., Lin, Y., Yang, R., Liu, L., Yin, M., Liao, S., Jiang, S., & He, J. (2023). Genetic Arg‐304‐His substitution in GRK5 protects against sepsis progression by alleviating NF‐κB‐mediated inflammation. International Immunopharmacology, 115, 109629. ; Xu, M., Wang, W., Pei, X., SUN, S., XU, M., & LIU, Z. (2014). Protective effects of the combination of sodium ferulate and oxymatrine on cecal ligation and puncture‐induced sepsis in mice. Experimental and Therapeutic Medicine, 7(5), 1297–1304. ; Yang, C.‐H., Tsai, P.‐S., Wang, T.‐Y., & Huang, C.‐J. (2009). Dexmedetomidine–ketamine combination mitigates acute lung injury in haemorrhagic shock rats. Resuscitation, 80, 1204–1210. ; Zhang, M. H., Li, G. Z., Xu, H., Zhang, J., & Cao, J. (2008). Effect of oxymatrine on NF‐kappaB and other cell factors in rats lung tissue with septic shock. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 33(20), 2390–2394. ; Zhang, X., Jiang, W., Zhou, A. L., Zhao, M., & Jiang, D. R. (2017). Inhibitory effect of oxymatrine on hepatocyte apoptosis via TLR4/PI3K/Akt/GSK‐3β signaling pathway. World Journal of Gastroenterology, 23(21), 3839–3849. ; Zhang, Y., & Ning, B. (2021). Signaling pathways and intervention therapies in sepsis. Signal Transduction and Targeted Therapy, 6(1), 407. ; Zhao, H., Zhang, Z., Chai, X., Li, G., Cui, H., Wang, H., Meng, Y., Liu, H., Wang, J., Li, R., Bai, Z., & Xiao, X. (2016). Oxymatrine attenuates CCl4‐induced hepatic fibrosis via modulation of TLR4‐dependent inflammatory and TGF‐β1 signaling pathways. International Immunopharmacology, 36, 249–255. ; Zhao, J., Wei, Q., Guo, S., et al. (2022). In Z. Dong, (Ed.), Efficacy of Oxymatrine Plus Antiviral in the Treatment of Sepsis and Its Effect on the Levels of Endotoxin and Inflammatory Factors (pp. 1–5). Evid Based Complement Alternat Med. ; Zhao, P., Zhou, R., Li, H. N., Yao, W. X., Qiao, H. Q., Wang, S. J., Niu, Y., Sun, T., Li, Y. X., & Yu, J. Q. (2015). Oxymatrine attenuated hypoxic‐ischemic brain damage in neonatal rats via improving antioxidant enzyme activities and inhibiting cell death. Neurochemistry International, 89, 17–27. ; Zhou, H., Shi, H. J., Yang, J., Chen, W. G., Xia, L., Song, H. B., Bo, K. P., & Ma, W. (2017). Efficacy of oxymatrine for treatment and relapse suppression of severe plaque psoriasis: Results from a single‐blinded randomized controlled clinical trial. British Journal of Dermatology, 176(6), 1446–1455. ; Zhu, C. S., Qiang, X., Chen, W., Li, J., Lan, X., Yang, H., Gong, J., Becker, L., Wang, P., Tracey, K. J., & Wang, H. (2023). Identification of procathepsin L (pCTS‐L)–neutralizing monoclonal antibodies to treat potentially lethal sepsis. Science Advances, 9, eadf4313.
- Grant Information: 20211464 Research Project of Traditional Chinese Medicine Bureau of Guangdong Province; 2022SRC004 Science and Technology Innovation Leading talents Project of Jieyang City; skjcx062 Science and Technology Project of Jieyang City; 2023A1515012477 Natural Science Foundation of Guangdong Province
- Contributed Indexing: Keywords: RAGE/HMGB1/NF‐κB; oxymatrine; sepsis
- Substance Nomenclature: 85U4C366QS (oxymatrine) ; 0 (Alkaloids) ; 0 (Quinolizines) ; 0 (NF-kappa B) ; 0 (HMGB1 Protein) ; 0 (Receptor for Advanced Glycation End Products) ; 0 (Lipopolysaccharides) ; 0 (Anti-Inflammatory Agents) ; 0 (Matrines)
- Entry Date(s): Date Created: 20240607 Date Completed: 20240607 Latest Revision: 20240614
- Update Code: 20240614
|