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Recent research has emphasized the role of macrophage-secreted factors on skeletal muscle metabolism. We studied Sargassum Serratifolium ethanol extract (ESS) in countering lipopolysaccharide (LPS)-induced changes in the macrophage transcriptome and their impact on skeletal muscle. Macrophage-conditioned medium (MCM) from LPS-treated macrophages (LPS-MCM) and ESS-treated macrophages (ESS-MCM) affected C2C12 myotube cells. LPS-MCM upregulated muscle atrophy genes and reduced glucose uptake, while ESS-MCM reversed these effects. RNA sequencing revealed changes in the immune system and cytokine transport pathways in ESS-treated macrophages. Protein analysis in ESS-MCM showed reduced levels of key muscle atrophy-related proteins, TNF-α, IL-6, IL-1, and GDF-15. These proteins play crucial roles in muscle function. These findings highlight the intricate relationship between the macrophage transcriptome and their secreted factors in either impairing or enhancing skeletal muscle function. ESS treatment has the potential to reduce macrophage-derived cytokines, preserving skeletal muscle function.

Titel:	Modulation of macrophage transcript and secretion profiles by Sargassum Serratifolium extract is associated with the suppression of muscle atrophy.
Autor/in / Beteiligte Person:	Ryu, H ; Jeong, HH ; Kim, MJ ; Lee, S ; Jung, WK ; Lee, B
Link:	Full Text Finder (Volltext)
Zeitschrift:	Scientific reports, Jg. 14 (2024-06-10), Heft 1, S. 13282
Veröffentlichung:	London : Nature Publishing Group, copyright 2011-, 2024
Medientyp:	academicJournal
ISSN:	2045-2322 (electronic)
DOI:	10.1038/s41598-024-63146-0
Schlagwort:	Animals Mice Transcriptome Lipopolysaccharides Cytokines metabolism Muscle, Skeletal metabolism Muscle, Skeletal drug effects Muscle, Skeletal pathology Cell Line Culture Media, Conditioned pharmacology Muscle Fibers, Skeletal metabolism Muscle Fibers, Skeletal drug effects Sargassum chemistry Macrophages metabolism Macrophages drug effects Plant Extracts pharmacology Plant Extracts chemistry Muscular Atrophy metabolism Muscular Atrophy drug therapy Muscular Atrophy pathology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Sci Rep] 2024 Jun 10; Vol. 14 (1), pp. 13282. <i>Date of Electronic Publication: </i>2024 Jun 10. MeSH Terms: Sargassum* / chemistry ; Macrophages* / metabolism ; Macrophages* / drug effects ; Plant Extracts* / pharmacology ; Plant Extracts* / chemistry ; Muscular Atrophy* / metabolism ; Muscular Atrophy* / drug therapy ; Muscular Atrophy* / pathology ; Animals ; Mice ; Transcriptome ; Lipopolysaccharides ; Cytokines / metabolism ; Muscle, Skeletal / metabolism ; Muscle, Skeletal / drug effects ; Muscle, Skeletal / pathology ; Cell Line ; Culture Media, Conditioned / pharmacology ; Muscle Fibers, Skeletal / metabolism ; Muscle Fibers, Skeletal / drug effects References: Nat Protoc. 2016 Sep;11(9):1650-67. (PMID: 27560171) ; Nature. 2021 Mar;591(7849):281-287. (PMID: 33568815) ; FASEB J. 2004 Jan;18(1):39-51. (PMID: 14718385) ; J Leukoc Biol. 2012 Oct;92(4):829-39. (PMID: 22753953) ; J Appl Physiol (1985). 2005 Mar;98(3):911-7. (PMID: 15542570) ; Am J Physiol Endocrinol Metab. 2002 Sep;283(3):E514-24. (PMID: 12169445) ; Am J Physiol Endocrinol Metab. 2015 May 1;308(9):E756-69. (PMID: 25714670) ; Springerplus. 2016 May 13;5:619. (PMID: 27330885) ; Biosci Rep. 2009 Feb;29(1):1-11. (PMID: 19143591) ; Nucleic Acids Res. 2000 Jan 1;28(1):27-30. (PMID: 10592173) ; Cell Death Discov. 2022 Apr 4;8(1):162. (PMID: 35379793) ; Biochim Biophys Acta. 2016 Nov;1861(11):1796-1807. (PMID: 27614008) ; J Exp Med. 2007 May 14;204(5):1057-69. (PMID: 17485518) ; Expert Rev Mol Med. 2011 Jul 11;13:e23. (PMID: 21740602) ; Exerc Sport Sci Rev. 2009 Jan;37(1):18-22. (PMID: 19098520) ; Am J Pathol. 2014 Apr;184(4):1167-1184. (PMID: 24525152) ; Nucleic Acids Res. 2023 Jan 6;51(D1):D587-D592. (PMID: 36300620) ; Immunity. 2012 Jan 27;36(1):68-78. (PMID: 22206904) ; Immunobiology. 2014 Mar;219(3):172-8. (PMID: 24080029) ; Mediators Inflamm. 2015;2015:805172. (PMID: 26508819) ; J Microbiol Biotechnol. 2024 Feb 28;34(2):270-279. (PMID: 38044678) ; PLoS One. 2010 Oct 12;5(10):e13262. (PMID: 20967264) ; Prev Nutr Food Sci. 2023 Mar 31;28(1):10-20. (PMID: 37066034) ; Nat Biotechnol. 2015 Mar;33(3):290-5. (PMID: 25690850) ; Am J Physiol Cell Physiol. 2004 Oct;287(4):C834-43. (PMID: 15355854) ; Diabetes. 2023 Aug 1;72(8):1070-1082. (PMID: 37224335) ; Res Immunol. 1998 Sep-Oct;149(7-8):685-8. (PMID: 9851524) ; Protein Sci. 2019 Nov;28(11):1947-1951. (PMID: 31441146) ; FASEB J. 2005 Mar;19(3):362-70. (PMID: 15746179) ; Methods. 2001 Dec;25(4):402-8. (PMID: 11846609) ; Am J Physiol Cell Physiol. 2009 Sep;297(3):C706-14. (PMID: 19625606) ; Nat Methods. 2015 Apr;12(4):357-60. (PMID: 25751142) ; Food Chem. 2019 Apr 25;278:178-184. (PMID: 30583359) Grant Information: RS-2023-00274576 National Research Foundation of Korea; 2021R1A6A1A03039211 National Research Foundation of Korea (NRF) grant funded by the Ministry of Education Contributed Indexing: Keywords: Sargassum Serratifolium; Cytokine; Macrophages; RNA Seq; Skeletal muscle Substance Nomenclature: 0 (Plant Extracts) ; 0 (Lipopolysaccharides) ; 0 (Cytokines) ; 0 (Culture Media, Conditioned) Entry Date(s): Date Created: 20240610 Date Completed: 20240610 Latest Revision: 20240613 Update Code: 20240613 PubMed Central ID: PMC11165015

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Modulation of macrophage transcript and secretion profiles by Sargassum Serratifolium extract is associated with the suppression of muscle atrophy.