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Currently, the increasing pollution of the environment by heavy metals is observed, caused both by natural factors and those related to human activity. They pose a significant threat to human health and life. It is therefore important to find an effective way of protecting organisms from their adverse effects. One potential product showing a protective effect is green tea. It has been shown that EGCG, which is found in large amounts in green tea, has strong antioxidant properties and can therefore protect cells from the adverse effects of heavy metals. Therefore, the aim of the study was to investigate the effect of EGCG on cells exposed to Cd. In the study, CHO-K1 cells (Chinese hamster ovary cell line) were treated for 24 h with Cd (5 and 10 µM) and EGCG (0.5 and 1 µM) together or separately. Cell viability, ATP content, total ROS activity, mitochondrial membrane potential and apoptosis potential were determined. The results showed that, in tested concentrations, EGCG enhanced the negative effect of Cd. Further analyses are needed to determine the exact mechanism of action of EGCG due to the small number of publications on the subject and the differences in the results obtained in the research.

Titel:	The physiological levels of epigallocatechin gallate (EGCG) enhance the Cd-induced oxidative stress and apoptosis in CHO-K1 cells.
Autor/in / Beteiligte Person:	Wnuk, E ; Zwolak, I ; Kochanowicz, E
Link:	Full Text Finder (Volltext)
Zeitschrift:	Scientific reports, Jg. 14 (2024-06-13), Heft 1, S. 13625
Veröffentlichung:	London : Nature Publishing Group, copyright 2011-, 2024
Medientyp:	academicJournal
ISSN:	2045-2322 (electronic)
DOI:	10.1038/s41598-024-64478-7
Schlagwort:	Animals CHO Cells Antioxidants pharmacology Cricetinae Adenosine Triphosphate metabolism Catechin analogs & derivatives Catechin pharmacology Apoptosis drug effects Cricetulus Oxidative Stress drug effects Cadmium toxicity Membrane Potential, Mitochondrial drug effects Reactive Oxygen Species metabolism Cell Survival drug effects
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Sci Rep] 2024 Jun 13; Vol. 14 (1), pp. 13625. <i>Date of Electronic Publication: </i>2024 Jun 13. MeSH Terms: Catechin* / analogs & derivatives ; Catechin* / pharmacology ; Apoptosis* / drug effects ; Cricetulus* ; Oxidative Stress* / drug effects ; Cadmium* / toxicity ; Membrane Potential, Mitochondrial* / drug effects ; Reactive Oxygen Species* / metabolism ; Cell Survival* / drug effects ; Animals ; CHO Cells ; Antioxidants / pharmacology ; Cricetinae ; Adenosine Triphosphate / metabolism References: J Appl Toxicol. 2024 Jan;44(1):129-147. (PMID: 37587800) ; Nutr Cancer. 2000;37(1):41-8. (PMID: 10965518) ; Int J Environ Res Public Health. 2020 May 26;17(11):. (PMID: 32466586) ; Methods Enzymol. 2001;335:217-31. (PMID: 11400370) ; Oxid Med Cell Longev. 2015;2015:476180. (PMID: 25918582) ; Toxicology. 2008 Jul 10;249(1):45-54. 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(PMID: 21129391) Grant Information: 2022/06/X/NZ7/00123 Narodowym Centrum Nauki Contributed Indexing: Keywords: Cadmium; Cell apoptosis; Cell viability; Epigallocatechin gallate; Mitochondrial membrane potential; Reactive oxygen species Substance Nomenclature: 8R1V1STN48 (Catechin) ; BQM438CTEL (epigallocatechin gallate) ; 00BH33GNGH (Cadmium) ; 0 (Reactive Oxygen Species) ; 0 (Antioxidants) ; 8L70Q75FXE (Adenosine Triphosphate) Entry Date(s): Date Created: 20240613 Date Completed: 20240613 Latest Revision: 20240616 Update Code: 20240616 PubMed Central ID: PMC11176361

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The physiological levels of epigallocatechin gallate (EGCG) enhance the Cd-induced oxidative stress and apoptosis in CHO-K1 cells.