Einzeltreffer — DigiBib

UVA exposure disturbs the metabolism of skin cells, often inducing oxidative stress and inflammation. Therefore, there is a need for bioactive compounds that limit such consequences without causing undesirable side effects. The aim of this study was to analyse in vitro the effects of the phytocannabinoids cannabigerol (CBG) and cannabidiol (CBD), which differ in terms of biological effects. Furthermore, the combined use of both compounds (CBG+CBD) has been analysed in order to increase their effectiveness in human skin fibroblasts and keratinocytes protection against UVA-induced alternation. The results obtained indicate that the effects of CBG and CBD on the redox balance might indeed be enhanced when both phytocannabinoids are applied concurrently. Those effects include a reduction in NOX activity, ROS levels, and a modification of thioredoxin-dependent antioxidant systems. The reduction in the UVA-induced lipid peroxidation and protein modification has been confirmed through lower levels of 4-HNE-protein adducts and protein carbonyl groups as well as through the recovery of collagen expression. Modification of antioxidant signalling (Nrf2/HO-1) through the administration of CBG+CBD has been proven to be associated with reduced proinflammatory signalling (NFκB/TNFα). Differential metabolic responses of keratinocytes and fibroblasts to the effects of the UVA and phytocannabinoids have indicated possible beneficial protective and regenerative effects of the phytocannabinoids, suggesting their possible application for the purpose of limiting the harmful impact of the UVA on skin cells.

Titel:	Modulation of Redox and Inflammatory Signaling in Human Skin Cells Using Phytocannabinoids Applied after UVA Irradiation: In Vitro Studies.
Autor/in / Beteiligte Person:	Wroński, A ; Jarocka-Karpowicz, I ; Surażyński, A ; Gęgotek, A ; Zarkovic, N ; Skrzydlewska, E
Link:	Full Text Finder (Volltext)
Zeitschrift:	Cells, Jg. 13 (2024-06-03), Heft 11
Veröffentlichung:	Basel, Switzerland : MDPI, 2024
Medientyp:	academicJournal
ISSN:	2073-4409 (electronic)
DOI:	10.3390/cells13110965
Schlagwort:	Humans Oxidative Stress drug effects Oxidative Stress radiation effects Antioxidants pharmacology Reactive Oxygen Species metabolism NF-E2-Related Factor 2 metabolism Lipid Peroxidation drug effects Lipid Peroxidation radiation effects Oxidation-Reduction drug effects Skin drug effects Skin radiation effects Skin metabolism Skin pathology Ultraviolet Rays adverse effects Cannabinoids pharmacology Signal Transduction drug effects Cannabidiol pharmacology Fibroblasts drug effects Fibroblasts metabolism Fibroblasts radiation effects Keratinocytes drug effects Keratinocytes radiation effects Keratinocytes metabolism Inflammation pathology Inflammation metabolism
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Cells] 2024 Jun 03; Vol. 13 (11). <i>Date of Electronic Publication: </i>2024 Jun 03. MeSH Terms: Oxidation-Reduction* / drug effects ; Skin* / drug effects ; Skin* / radiation effects ; Skin* / metabolism ; Skin* / pathology ; Ultraviolet Rays* / adverse effects ; Cannabinoids* / pharmacology ; Signal Transduction* / drug effects ; Cannabidiol* / pharmacology ; Fibroblasts* / drug effects ; Fibroblasts* / metabolism ; Fibroblasts* / radiation effects ; Keratinocytes* / drug effects ; Keratinocytes* / radiation effects ; Keratinocytes* / metabolism ; Inflammation* / pathology ; Inflammation* / metabolism ; Humans ; Oxidative Stress / drug effects ; Oxidative Stress / radiation effects ; Antioxidants / pharmacology ; Reactive Oxygen Species / metabolism ; NF-E2-Related Factor 2 / metabolism ; Lipid Peroxidation / drug effects ; Lipid Peroxidation / radiation effects References: Cells. 2019 Aug 03;8(8):. (PMID: 31382646) ; Molecules. 2022 Oct 10;27(19):. (PMID: 36235276) ; Molecules. 2022 Jan 13;27(2):. (PMID: 35056807) ; Free Radic Biol Med. 2021 Feb 20;164:258-270. (PMID: 33453360) ; Toxicology. 2023 Apr;488:153460. (PMID: 36796712) ; Redox Biol. 2020 Jan;28:101321. (PMID: 31518892) ; Exp Dermatol. 2020 Jul;29(7):616-622. (PMID: 32367548) ; J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 5;822(1-2):61-9. (PMID: 15979953) ; Adv Exp Med Biol. 2017;996:71-87. (PMID: 29124692) ; Bioorg Chem. 2023 Nov;140:106810. (PMID: 37659147) ; Front Pharmacol. 2017 Jun 28;8:422. (PMID: 28701957) ; Inflamm Res. 2022 Aug;71(7-8):817-831. (PMID: 35748903) ; J Biol Chem. 2003 Jun 20;278(25):22546-54. (PMID: 12692136) ; Anal Biochem. 2017 May 1;524:31-44. (PMID: 27530652) ; Nat Rev Drug Discov. 2019 Apr;18(4):295-317. (PMID: 30610225) ; J Periodontal Res. 2022 Dec;57(6):1127-1138. (PMID: 36070347) ; J Mol Signal. 2016 May 05;11:2. (PMID: 31051015) ; Br J Pharmacol. 2011 Aug;163(7):1479-94. (PMID: 21175579) ; Oxid Med Cell Longev. 2020 Feb 12;2020:2576823. (PMID: 32104530) ; J Biochem. 2018 Jun 1;163(6):489-501. (PMID: 29365138) ; Drug Des Devel Ther. 2022 Jan 06;16:23-66. (PMID: 35027818) ; Free Radic Biol Med. 2017 Oct;111:209-218. (PMID: 27840321) ; Medicina (Kaunas). 2019 Nov 18;55(11):. (PMID: 31752240) ; Nat Rev Immunol. 2021 Jul;21(7):411-425. (PMID: 33514947) ; J Lab Clin Med. 1967 Jul;70(1):158-69. (PMID: 6066618) ; Anal Biochem. 1976 May 7;72:248-54. (PMID: 942051) ; J Neuroimmune Pharmacol. 2012 Dec;7(4):1002-16. (PMID: 22971837) ; Methods Enzymol. 1990;186:464-78. (PMID: 1978225) ; Cells. 2022 Dec 16;11(24):. (PMID: 36552866) ; Antioxidants (Basel). 2019 Nov 20;8(12):. (PMID: 31756938) ; PLoS Genet. 2016 Jan 25;12(1):e1005800. (PMID: 26808544) ; Biochem Biophys Res Commun. 2011 Jul 15;410(4):726-31. (PMID: 21679691) ; Fitoterapia. 2021 Sep;153:104992. (PMID: 34273440) ; Evid Based Complement Alternat Med. 2022 Nov 8;2022:3336516. (PMID: 36397993) ; Front Pharmacol. 2017 Feb 03;8:20. (PMID: 28217094) ; Sci Rep. 2020 Nov 23;10(1):20405. (PMID: 33230154) ; J Biol Chem. 1972 May 25;247(10):3170-5. (PMID: 4623845) ; Clin Ter. 2019 Mar-Apr;170(2):e93-e99. (PMID: 30993303) ; Redox Biol. 2013 Feb 08;1:226-33. (PMID: 24024156) ; Redox Biol. 2022 Nov;57:102489. (PMID: 36198205) ; J Invest Dermatol. 2008 Jan;128(1):214-22. (PMID: 17611574) ; Inflamm Bowel Dis. 2018 Mar 19;24(4):680-697. (PMID: 29562280) ; Methods Enzymol. 1995;252:199-208. (PMID: 7476354) ; Mol Immunol. 2021 Jul;135:21-27. (PMID: 33857815) ; Int J Mol Sci. 2023 Jan 25;24(3):. (PMID: 36768709) ; J Photochem Photobiol B. 2020 Mar;204:111810. (PMID: 32028189) ; J Biol Chem. 1962 May;237:1589-95. (PMID: 14474846) ; J Pharmacol Exp Ther. 2018 Jun;365(3):652-663. (PMID: 29632236) ; J Nat Prod. 2020 May 22;83(5):1711-1715. (PMID: 32315173) ; Cells. 2021 Feb 05;10(2):. (PMID: 33562819) ; Cells. 2023 Sep 09;12(18):. (PMID: 37759466) ; J Cosmet Dermatol. 2021 Nov;20(11):3427-3431. (PMID: 33655657) ; Cells. 2019 Aug 28;8(9):. (PMID: 31466340) ; Antioxidants (Basel). 2020 Jan 13;9(1):. (PMID: 31941059) ; Int J Oncol. 2017 Jul;51(1):369-377. (PMID: 28560402) ; Front Pharmacol. 2018 Jun 21;9:632. (PMID: 29977202) ; Biofactors. 2022 May;48(3):611-633. (PMID: 35229925) ; J Dermatolog Treat. 2020 Dec;31(8):839-845. (PMID: 31599175) ; AIMS Genet. 2017 Apr 18;4(2):103-137. (PMID: 31435505) ; Int J Mol Sci. 2018 Jul 08;19(7):. (PMID: 29986533) ; Biomolecules. 2020 Feb 28;10(3):. (PMID: 32121131) ; J Photochem Photobiol B. 2020 Aug;209:111948. (PMID: 32679512) ; Oxid Med Cell Longev. 2019 Nov 21;2019:5416728. (PMID: 31885801) ; Free Radic Biol Med. 2000 Feb 1;28(3):418-27. (PMID: 10699754) ; Planta Med. 2022 Jun;88(7):492-506. (PMID: 33851375) ; Oncotarget. 2020 Mar 31;11(13):1141-1156. (PMID: 32284791) ; Ann N Y Acad Sci. 2012 Oct;1271:75-81. (PMID: 23050967) ; Chem Res Toxicol. 2018 Feb 19;31(2):137-144. (PMID: 29272108) ; Int J Mol Sci. 2023 Aug 04;24(15):. (PMID: 37569799) ; J Cosmet Dermatol. 2021 Jul;20(7):2277-2286. (PMID: 33095946) ; Biomolecules. 2022 Jun 20;12(6):. (PMID: 35740979) ; J Pharmacol Exp Ther. 2021 Feb;376(2):204-212. (PMID: 33168643) ; Pharmacol Res. 2020 Sep;159:104940. (PMID: 32470563) ; Int Immunopharmacol. 2015 Dec;29(2):246-253. (PMID: 26590114) ; Toxicol Lett. 2006 Jan 5;160(2):171-7. (PMID: 16111842) ; Biomedicines. 2022 Jul 21;10(7):. (PMID: 35885063) ; Photochem Photobiol. 2020 Jul;96(4):779-797. (PMID: 31886889) ; Fitoterapia. 2021 Jul;152:104915. (PMID: 33964342) ; Methods Enzymol. 1984;105:121-6. (PMID: 6727660) ; J Dermatol Sci. 2013 Feb;69(2):89-94. (PMID: 23219896) ; Circ Res. 1994 Jun;74(6):1141-8. (PMID: 8187280) ; Free Radic Biol Med. 2001 Mar 1;30(5):537-46. (PMID: 11182524) ; Eur J Histochem. 2017 Jan 23;61(1):2749. (PMID: 28348416) Contributed Indexing: Keywords: UVA radiation; fibroblasts; inflammation; keratinocytes; phytocannabinoids; redox balance Substance Nomenclature: 0 (Cannabinoids) ; 19GBJ60SN5 (Cannabidiol) ; 0 (Antioxidants) ; J1K406072N (cannabigerol) ; 0 (Reactive Oxygen Species) ; 0 (NF-E2-Related Factor 2) Entry Date(s): Date Created: 20240619 Date Completed: 20240619 Latest Revision: 20240620 Update Code: 20240620 PubMed Central ID: PMC11171479

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

Modulation of Redox and Inflammatory Signaling in Human Skin Cells Using Phytocannabinoids Applied after UVA Irradiation: In Vitro Studies.